全新肿瘤免疫治疗药物CTLA-4阻断型纳米抗体的抗肿瘤作用研究

81673344
2016
H3404.生物技术药物
万亚坤
面上项目
研究员
中国科学院上海药物研究所
51万元
肿瘤治疗;CTLA-4;免疫检查点;肿瘤免疫逃逸;纳米抗体
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 A novel bispecific nanobody with PD-L1/TIGIT dual immune checkpoint blockade 期刊论文 Linlin Ma;Junwei Gai;Peng Qiao;Yanfei Li;Xiaofei Li;Min Zhu;Guanghui Li;Yakun Wan
2 Sensitive detection of Bacillus thuringiensis Cry1B toxin based on camel single-domain antibodies. 期刊论文 Zhong Wenjing;Li Guanghui;Yu Xiaolu;Zhu Min;Gong Likun;Wan Yakun
3 Simultaneous Unlocking Optoelectronic and Interfacial Properties of C-60 for Ultrasensitive Immunosensing by Coupling to Metal-Organic Framework 期刊论文 Zhou Qing;Li Guanghui;Chen Kaiyang;Yang Hong;Yang Mengran;Zhang Yuye;Wan Yakun;Shen Yanfei;Zhang Yuanjian
4 Construction of Anti-hPD-L1 HCAb Nb6 and in Situ I-124 Labeling for Noninvasive Detection of PD-L1 Expression in Human Bone Sarcoma 期刊论文 Huang Hai-Feng;Zhu Hua;Li Guang-Hui;Xie Quan;Yang Xian-Teng;Xu Xiao-Xia;Tian Xiao-Bin;Wan Ya-Kun;Yang Zhi
5 Preclinical development of a novel CD47 nanobody with less toxicity and enhanced anti-cancer therapeutic potential 期刊论文 Linlin Ma;Min Zhu;Junwei Gai;Guanghui Li;Qing Chang;Peng Qiao;Longlong Cao;Wanqing Chen;Siyuan Zhang;Yakun Wan
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