靶向Hsp90中间结构域的新型抗肿瘤抑制剂发现及其效应机制研究
21778061
2017
B0702.生物分子的化学生物学
张乃霞
面上项目
研究员
中国科学院上海药物研究所
65万元
变构调节;核磁共振;Hsp90;蛋白-蛋白相互作用干预;新型抗肿瘤抑制剂
2018-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Interplay between Alzheimer's Disease and Global Glucose Metabolism Revealed by the Metabolic Profile Alterations of Pancreatic Tissue and Serum in APP/PS1 Transgenic Mice | 期刊论文 | Liu Xia;Wang Wei;Chen Hua-Li;Zhang Hai-Yan;Zhang Nai-Xia |
| 2 | Expression, Purification and Characterization of the Second DUSP Domain of Deubiquitinase USP20/VDU2 | 期刊论文 | Hu Shuwei;Chen Xiaoyu;Zhu Mengying;Hu Huifang;Zhou Chen;Shi Li;Zhang Naixia |
| 3 | Applications of Solution NMR in Drug Discovery | 期刊论文 | Shi Li;Zhang Naixia |
| 4 | USP28 and USP25 are Downregulated by Vismodegib in Vitro and in Colorectal Cancer Cell Lines | 期刊论文 | Wang Hui;Meng Qian;Ding Yiluan;Xiong Muya;Zhu Mengying;Yang Yuanyuan;Su Haixia;Gu Lei;Xu Yechun;Shi Li;Zhou Hu;Zhang Naixia |
| 5 | Protective Effects of 28-O-Caffeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis | 期刊论文 | Liu Xia;Ruan Zhi;Shao Xing-cheng;Feng Hong-xuan;Wu Lei;Wang Wei;Wang Hong-min;Mu Hong-yan;Zhang Ru-jun;Zhao Wei-min;Zhang Hai-yan;Zhang Nai-xia |
| 6 | Allosteric Regulation of Hsp90α's Activity by Small Molecules Targeting the Middle Domain of the Chaperone | 期刊论文 | Zhou Chen;Zhang Chi;Zhu Hongwen;Liu Zhijun;Su Haixia;Zhang Xianglei;Chen Tingting;Zhong Yan;Hu Huifang;Xiong Muya;Zhou Hu;Xu Yechun;Zhang Ao;Zhang Naixia |
| 7 | Structural and Functional Studies of USP20 ZnF-UBP Domain by NMR | 期刊论文 | Yang Yuanyuan;Ding Yiluan;Zhou Chen;Wen Yi;Zhang Naixia |
| 8 | Aha1 Exhibits Distinctive Dynamics Behavior and Chaperone-Like Activity | 期刊论文 | Hu Huifang;Wang Qing;Du Jingwen;Liu Zhijun;Ding Yiluan;Xue Hongjuan;Zhou Chen;Feng Linyin;Zhang Naixia |
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