含氮多环类药性化合物库的构建与创新药物发现及可视化研究

21632008
2016
B01.合成化学
柳红
重点项目
研究员
中国科学院上海药物研究所
300万元
高效合成方法;先导化合物;个性化药物;化合物库;分子成像
2017-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 2018-2019年度三好学生称号 奖励 韩旭
2 A removable directing group-assisted Rh(iii)-catalyzed direct C-H bond activation/annulation cascade to synthesize highly fused isoquinolines. 期刊论文 Yilang Cheng;Xu Han;Junyou Li;Yu Zhou;Hong Liu
3 第11届世界华人药物化学研讨会优秀墙报奖 奖励 吴成林
4 Targeted Delivery of a gamma-Glutamyl Transpeptidase Activatable Near-Infrared-Fluorescent Probe for Selective Cancer Imaging 期刊论文 Luo Zhiliang;Huang Zheng;Li Ke;Sun Yidan;Lin Jianguo;Ye Deju;Chen Hong-Yuan
5 2017年硕士研究生国家奖学金 奖励 李亚洲
6 Rh(III)-Catalyzed C-H Cyclization of Arylnitrones with Diazo Compounds: Access to 3-Carboxylate Substituted N-Hydroxyindoles 期刊论文 Li Yazhou;Li Jian;Wei Xiao;Zhou Yu;Liu Hong
7 H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo. 期刊论文 Luyan Wu;Yusuke Ishigaki;Yuxuan Hu;Keisuke Sugimoto;Wenhui Zeng;Takashi Harimoto;Yidan Sun;Jian He;Takanori Suzuki;Xiqun Jiang;Hong-Yuan Chen;Deju Ye
8 MALT1 as a Promising Target to Treat Lymphoma and Other Diseases Related to MALT1 Anomalies. 期刊论文 Xuewu Liang;YiChun Cao;Chunpu Li;Haolan Yu;Chenghua Yang;Hong Liu
9 一种六氢二苯并[a,g]喹嗪类化合物的药物用途-俄罗斯 专利 柳红;谢欣;孙海丰;李静;赵飞;陈颖;栗增;周宇;蒋华良;陈凯先
10 一种C,O-螺环芳基糖苷类化合物及其制备和应用-俄罗斯 专利 柳红;李佳;王江;李静雅;陈辉;李丹;李建;王一冰;蒋华良;陈凯先
11 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途-俄罗斯 专利 柳红;李佳;王江;苏明波;王姝妮;周宇波;朱未;徐威;李淳朴;蒋华良;陈凯先
12 一种六氢二苯并[a,g]喹嗪类化合物的药物用途-中国 专利 柳红;谢欣;孙海峰;李静;赵飞;陈颖;栗增;周宇;蒋华良;陈凯先
13 Discovery of Pyrazolo[3,4‑d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation. 期刊论文 Xiaoqin Tan;Chunpu Li;Ruirui Yang;Sen Zhao;Fei Li;Xutong Li;Lifan Chen;Xiaozhe Wan;Xiaohong Liu;Tianbiao Yang;Xiaochu Tong;Tingyang Xu;Rongrong Cui;Hualiang Jiang;Sulin Zhang;Hong Liu;Mingyue Zheng
14 Enzyme-mediated in situ self-assembly promotes in vivo bioorthogonal reaction for pretargeted multimodality imaging. 期刊论文 Yuxuan Hu;Junya Zhang;Yinxing Miao;Xidan Wen;Jian Wang;Yidan Sun;Yinfei Chen;Jianguo Lin;Ling Qiu;Kai Guo;Hong-Yuan Chen;Deju Ye
15 Smart Magnetic and Fluorogenic Photosensitizer Nanoassemblies Enable Redox-Driven Disassembly for Photodynamic Therapy 期刊论文 An Ruibing;Cheng Xiaoyang;Wei Shixuan;Hu Yuxuan;Sun Yidan;Huang Zheng;Chen Hong-Yuan;Ye Deju
16 A Rh(III)-catalyzed C–H activation/regiospecific annulation cascade of benzoic acids with propargyl acetates to unusual 3-alkylideneisochromanones. 期刊论文 Jiyuan Li;Feifei Fang;Run Wang;Yuan Li;Bin Xu;Hong Liu;Yu Zhou
17 Recent advances in stimuli-responsive in situ self-assembly of small molecule probes for in vivo imaging of enzymatic activity 期刊论文 Yuqi Wang;Jianhui Weng;Xidan Wen;Yuxuan Hu;Deju Ye
18 Activatable NIR Fluorescence/MRI Bimodal Probes for in Vivo Imaging by Enzyme-Mediated Fluorogenic Reaction and Self-Assembly 期刊论文 Yan Runqi;Hu Yuxuan;Liu Fei;Wei Shixuan;Fang Daqing;Shuhendler Adam J.;Liu Hong;Chen Hong-Yuan;Ye Deju
19 Tumor-targeting CuS nanoparticles for multimodal imaging and guided photothermal therapy of lymph node metastasis 期刊论文 Shi Hua;Yan Runqi;Wu Luyan;Sun Yidan;Liu Song;Zhou Zhengyang;He Jian;Ye Deju
20 Analysis of crystallographic structures of Ni(II) complexes of a-amino acid Schiff bases: elucidation of the substituent effect on stereochemical preferences 期刊论文 Nian Yong;Wang Jiang;Moriwaki Hiroki;Soloshonok Vadim A.;Liu Hong
21 An activatable ratiometric near-infrared fluorescent probe for hydrogen sulfide imaging in vivo. 期刊论文 Luyan Wu;Wenhui Zeng;Liandong Feng;Yuxuan Hu;Yidan Sun;Yingxiao Yan;Hong-Yuan Chen;Deju Ye
22 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途-加拿大 专利 柳红;李佳;王江;苏明波;王姝妮;周宇波;朱未;徐威;李淳朴;蒋华良;陈凯先
23 一类氟取代的环状胺类化合物及其制备方法、药物组合物和用途-欧洲 专利 柳红;章海燕;周宇;傅燕;蒋华良;唐希灿;陈凯先
24 一种六氢二苯并[a,g]喹嗪类化合物的药物用途-日本 专利 柳红;谢欣;孙海丰;李静;赵飞;陈颖;栗增;周宇;蒋华良;陈凯先
25 激活型纳米探针及其生物应用 专利 叶德举;陈洪渊;徐静娟;沈益忠;孙一丹
26 苯基[a]吲哚[2,3-g]并喹嗪类化合物、其制备方法、药物组合物及其应用-美国 专利 柳红;王逸平;赵飞;赵晶;王江;席聪;吴成林;沈昊;韩旭;蒋华良;陈凯先
27 一种C,O-螺环芳基糖苷类化合物及其制备和应用-加拿大 专利 柳红;李佳;王江;李静雅;陈辉;李丹;李建;王一冰;蒋华良;陈凯先
28 一种C,O-螺环芳基糖苷类化合物及其制备和应用-美国 专利 柳红;李佳;王江;李静雅;陈辉;李丹;李建;王一冰;蒋华良;陈凯先
29 一种六氢二苯并[a,g]喹嗪类化合物的药物用途-澳大利亚 专利 柳红;谢欣;孙海丰;李静;赵飞;陈颖;栗增;周宇;蒋华良;陈凯先
30 一类氟取代的环状胺类化合物及其制备方法、药物组合物和用途-中国香港 专利 柳红;章海燕;周宇;傅燕;蒋华良;唐希灿;陈凯先
31 Dual Stimuli-Responsive Nanoparticles for Controlled Release of Anticancer and Anti-inflammatory Drugs Combination 期刊论文 Feng Liandong;Wang Yuqi;Luo Zhiliang;Huang Zheng;Zhang Yan;Guo Kai;Ye Deju
32 A Photoacoustic Probe for the Imaging of Tumor Apoptosis by Caspase-Mediated Macrocyclization and Self-Assembly 期刊论文 Wang Yuqi;Hu Xiaoming;Weng Jianhui;Li Jinbo;Fan Quli;Zhang Kin;Ye Deju
33 2017年长三角药物化学研讨会优秀墙报奖 奖励 高峰
34 An Activatable Chemiluminescent Probe for Sensitive Detection of gamma-Glutamyl Transpeptidase Activity in Vivo 期刊论文 An Ruibing;Wei Shixuan;Huang Zheng;Liu Fei;Ye Deju
35 ATP-Activatable Photosensitizer Enables Dual Fluorescence Imaging and Targeted Photodynamic Therapy of Tumor 期刊论文 Shen Yizhong;Tian Qian;Sun Yidan;Xu Jing-Juan;Ye Deju;Chen Hong-Yuan
36 Responsive Trimodal Probes for In Vivo Imaging of Liver Inflammation by Coassembly and GSH-Driven Disassembly 期刊论文 Yuxuan Hu;Yuqi Wang;Xidan Wen;Yifan Pan;Xiaoyang Cheng;Ruibing An;Guandao Gao;Hong-Yuan Chen;Deju Ye
37 苏州胶囊奖学金二等奖学金 奖励 方非非
38 Firefly Luciferin‐Inspired Biocompatible Chemistry for Protein Labeling and In Vivo Imaging. 期刊论文 Yuqi Wang;Ruibing An;Zhiliang Luo;Deju Ye
39 一种六氢二苯并[a,g]喹嗪类化合物的药物用途-印度 专利 柳红;谢欣;孙海丰;李静;赵飞;陈颖;栗增;周宇;蒋华良;陈凯先
40 一种C,O-螺环芳基糖苷类化合物及其制备和应用-韩国 专利 柳红;李佳;王江;李静雅;陈辉;李丹;李建;王一冰;蒋华良;陈凯先
41 Noninvasive ratiometric fluorescence imaging of γ-glutamyltransferase activity using an activatable probe. 期刊论文 Zheng Huang;Ruibing An;Shixuan Wei;Jinfang Wang;Deju Ye
42 Rhodium-Catalyzed C-H Activation/Annulation Cascade of Aryl Oximes and Propargyl Alcohols to Isoquinoline N-Oxides. 期刊论文 Yuan Li;Feifei Fang;Jianhui Zhou;Jiyuan Li;Run Wang;Hong Liu;Yu Zhou
43 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途-中国 专利 柳红;李佳;王江;苏明波;王姝妮;周宇波;朱未;徐威;李淳朴;蒋华良;陈凯先
44 一种C,O-螺环芳基糖苷类化合物及其制备和应用-中国 专利 柳红;李佳;王江;李静雅;陈辉;李丹;李建;王一冰;蒋华良;陈凯先
45 苯基[a]吲哚[2,3-g]并喹嗪类化合物、其制备方法、药物组合物及其应用-中国 专利 柳红;王逸平;赵飞;赵晶;王江;席聪;吴成林;沈昊;韩旭;蒋华良;陈凯先
46 一类氟取代的环状胺类化合物及其制备方法、药物组合物和用途-加拿大 专利 柳红;章海燕;周宇;傅燕;蒋华良;唐希灿;陈凯先
47 一类氟取代的环状胺类化合物及其制备方法、药物组合物和用途-美国 专利 柳红;章海燕;周宇;傅燕;蒋华良;唐希灿;陈凯先
48 GGT激活型化学发光探针及其合成方法和应用 专利 叶德举;安瑞冰;魏世轩
49 Magnetic Semiconductor Gd-Doping CuS Nanoparticles as Activatable Nanoprobes for Bimodal Imaging and Targeted Photothermal Therapy of Gastric Tumors 期刊论文 Shi Hua;Sun Yidan;Yan Runqi;Liu Shunli;Zhu Li;Liu Song;Feng Yuzhang;Wang Peng;He Jian;Zhou Zhengyang;Ye Deju
50 上海市优秀毕业生 奖励 吴小伟
51 先导化合物结构优化策略(九) ——改善药物清除率. 期刊论文 张蕊;王江;朱浩然;柳红
52 Coordination mode-induced isomeric cyclometalated [Ir(tpy)(nbi)Cl](PF6) complexes: distinct luminescence, self-assembly and cellular imaging behaviors 期刊论文 Gao Tai-Bao;Yan Run-Qi;Metherell Alexander J.;Cao Deng-Ke;Ye De-Ju;Ward Michael D.
53 Nanoporous Semiconductor Electrode Captures the Quantum Dots: Toward Ultrasensitive Signal-On Liposomal Photoelectrochemical Immunoassay 期刊论文 Xue Tie-Ying;Mei Li-Ping;Xu Yi-Tong;Liu Yi-Li;Fan Gao-Chao;Li Heng-Ye;Ye Deju;Zhao Wei-Wei
54 Sulfoximines Assisted Rh(III)-Catalyzed C−H Activation/Annulation Cascade to Synthesize Highly Fused Indeno-1,2-benzothiazines. 期刊论文 Jian Li;Hui Li;Daqing Fang;Lingjun Liu;Xu Han;Jina Sun;Chunpu Li;Yu Zhou;Deju Ye;Hong Liu
55 Ratiometric Imaging of MMP-2 Activity facilitates Tumor Detection Using Activatable Near-Infrared Fluorescent Semiconducting Polymer Nanoparticles. 期刊论文 Wenhui Zeng;Luyan Wu;Yidan Sun;Yuqi Wang;Jingfang Wang;Deju Ye
56 先导化合物结构优化策略(八)——药物转运体及其相关药物设计策略. 期刊论文 宋晓翰;王江;柳红
57 氮杂环卡宾催化有机反应的研究进展 期刊论文 王翱;肖永龙;周宇;徐进宜;柳红
58 一种六氢二苯并[a,g]喹嗪类化合物的药物用途-美国 专利 柳红;谢欣;孙海丰;李静;赵飞;陈颖;栗增;周宇;蒋华良;陈凯先
59 一种C,O-螺环芳基糖苷类化合物及其制备和应用-澳大利亚 专利 柳红;李佳;王江;李静雅;陈辉;李丹;李建;王一冰;蒋华良;陈凯先
60 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途-美国 专利 柳红;李佳;王江;苏明波;王姝妮;周宇波;朱未;徐威;李淳朴;蒋华良;陈凯先
61 第十六届中国药学会科学技术一等奖 奖励 柳红(第一完成人)
62 Rh(III)-Catalyzed [5 + 1] Annulation of Indole-enaminones with Diazo Compounds To Form Highly Functionalized Carbazoles. 期刊论文 Zhidong Jiang;Jianhui Zhou;Haoran Zhu;Hong Liu;Yu Zhou
63 Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate. 期刊论文 Yu Zhou;Yan Fu;Wanchao Yin;Jian Li;Wei Wang;Fang Bai;Shengtao Xu;Qi Gong;Tao Peng;Yu Hong;Dong Zhang;Dan Zhang;Qiufeng Liu;Yechun Xu;H. Eric Xu;Haiyan Zhang;Hualiang Jiang;Hong Liu
64 Ir(I)-Catalyzed C-H Glycosylation for Synthesis of 2-Indolyl-CDeoxyglycosides. 期刊论文 Changyue Yu;Yichu Liu;Xiong Xie;Shulei Hu;Shurui Zhang;Mingjie Zeng;Dan Zhang;Jiang Wang;Hong Liu
65 一种碱性磷酸酶响应的双模态探针P-CyFF-68Ga及其制备方法与应用 专利 叶德举;胡宇轩;缪银杏;张俊雅
66 苯基[a]吲哚[2,3-g]并喹嗪类化合物、其制备方法、药物组合物及其应用-日本 专利 柳红;王逸平;赵飞;赵晶;王江;席聪;吴成林;沈昊;韩旭;蒋华良;陈凯先
67 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途-韩国 专利 柳红;李佳;王江;苏明波;王姝妮;周宇波;朱未;徐威;李淳朴;蒋华良;陈凯先
68 2017年-2018年三好学生称号 奖励 高峰
69 Generation of hydroxyl radical-activatable ratiometric near-infrared bimodal probes for early monitoring of tumor response to therapy. 期刊论文 Luyan Wu;Yusuke Ishigaki;Wenhui Zeng;Takashi Harimoto;Baoli Yin;Yinghan Chen;Shiyi Liao;Yongchun Liu;Yidan Sun;Xiaobo Zhang;Ying Liu;Yong Liang;Pengfei Sun;Takanori Suzuki;Guosheng Song;Quli Fan;Deju Ye
70 Degradable hybrid CuS nanoparticles for imaging-guided synergistic cancer therapy via low-power NIR-II light excitation. 期刊论文 Yidan Sun;Hua Shi;Xiaoyang Cheng;Luyan Wu;Yuqi Wang;Zhengyang Zhou;Jian He;Hong-Yuan Chen;Deju Ye
71 Discovery of Novel Pyrrolo[2,3‑d]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors. 期刊论文 Xuewu Liang;Shuai Tang;Xuyi Liu;Yingluo Liu;Qifu Xu;Xiaomin Wang;Abdusaid Saidahmatov;Chunpu Li;Jiang Wang;Yu Zhou;Yingjie Zhang;Meiyu Geng;Min Huang;Hong Liu
72 Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design 期刊论文 Wang Yulan;Dai Yang;Wu Xiaowei;Li Fei;Liu Bo;Li Chunpu;Liu Qiufeng;Zhou Yuanyang;Wang Bao;Zhu Mingrui;Cui Rongrong;Tan Xiaoqin;Xiong Zhaoping;Liu Jia;Tan Minjia;Xu Yechun;Geng Meiyu;Jiang Hualiang;Liu Hong;Ai Jing;Zheng Mingyue
73 A metal-free method for the facile synthesis of indanones via the intramolecular hydroacylation of 2-vinylbenzaldehyde. 期刊论文 Guoxue He;Jinyu Ma;Jianhui Zhou;Chunpu Li;Hong Liu;Yu Zhou
74 Recent Advances in the Development of Optical Imaging Probes for γ-Glutamyltranspeptidase. 期刊论文 Zhiliang Luo;Ruibing An;Deju Ye
75 一类氟取代的环状胺类化合物及其制备方法、药物组合物和用途-印度 专利 柳红;章海燕;周宇;傅燕;蒋华良;唐希灿;陈凯先
76 苯基[a]吲哚[2,3-g]并喹嗪类化合物、其制备方法、药物组合物及其应用-韩国 专利 柳红;王逸平;赵飞;赵晶;王江;席聪;吴成林;沈昊;韩旭;蒋华良;陈凯先
77 一种C,O-螺环芳基糖苷类化合物及其制备和应用-日本 专利 柳红;李佳;王江;李静雅;陈辉;李丹;李建;王一冰;蒋华良;陈凯先
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