利用基因编辑技术创建Shank3突变自闭症家犬模型
31830036
2018
C0913.神经科学与心理学研究的新技术和新范式
张永清
重点项目
研究员
中国科学院遗传与发育生物学研究所
295万元
自闭症;基因编辑;社交行为;Shank3;家犬
2019-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury | 期刊论文 | Tingting Li;Wenwen Shi;Margaret S. Ho;Yong Q. Zhang |
| 2 | 计算行为学研究进展 | 期刊论文 | 任炜;余山;张永清 |
| 3 | 一种利用多单元装置评价犬与犬社交能力的方法 | 专利 | 米继东;赵建平;张永清;田瑞 |
| 4 | Left-right asymmetry and attractor-like dynamics of dog’s tail wagging during dog-human interactions | 期刊论文 | Wei Ren;Pengfei Wei;Shan Yu;Yong Q. Zhang |
| 5 | Impaired synaptic function and hyperexcitability of the pyramidal neurons in the prefrontal cortex of autism-associated Shank3 mutant dogs | 期刊论文 | Feipeng Zhu;Qi Shi;Yong-Hui Jiang;Yong Q Zhang;Hui Zhao |
| 6 | 记忆神经环路与分子机制 | 奖励 | 鲁友明;朱铃强;韩芸耘;田青;张永清 |
| 7 | A dog carrying mutations in AVP-NPII exhibits key features of central diabetes insipidus | 期刊论文 | Huijuan Xu;Haiyang Hao;Shirui Wang;Xueru Liu;Wen Lyu;Zhentao Zuo;Yan Zhuo;Jidong Mi;Yong Q Zhang;Rui Tian;Huijuan Zhu |
| 8 | 一种饲养笼装置及犬与人社交能力的评价方法 | 专利 | 米继东;赵建平;张永清;田瑞 |
| 9 | 激光适配器及光学系统 | 专利 | 吴润龙;田景全;胡炎辉;云子艳;王爱民;程和平 |
| 10 | 一种用于评价犬与人社交能力的测试装置及方法 | 专利 | 米继东;赵建平;张永清;田瑞 |
| 11 | Comparative Proteome and Cis-Regulatory Element Analysis Reveals Specific Molecular Pathways Conserved in Dog and Human Brains | 期刊论文 | Huilin Hong;Zhiguang Zhao;Xiahe Huang;Chao Guo;Hui Zhao;Guo-Dong Wang;Ya-Ping Zhang;Jian-Ping Zhao;Jianhui Shi;Qing-Feng Wu;Yong-Hui Jiang;Yingchun Wang;Lei M Li;Zhuo Du;Yong Q Zhang;Ying Xiong |
| 12 | High-power, 474 fs, 31.12 MHz, all-polarizationmaintaining, 1560 nm fiber laser system based onthe chirped-pulse amplification | 期刊论文 | Rong Xu;Yizhou Liu;Wenchao Qiao;Guanzhong Li;Tianli Feng;Chunzhu Zhao;Xian Zhao;Aimin Wang;Tao Li |
| 13 | Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing | 期刊论文 | Rui Tian;Yuan Li;Hui Zhao;Wen Lyu;Jianping Zhao;Xiaomin Wang;Heng Lu;Huijuan Xu;Wei Ren;Qing-quan Tan;Qi Shi;Guo-dong Wang;Ya-ping Zhang;Liangxue Lai;Jidong Mi;Yong-hui Jiang;Yong Q. Zhang |
| 14 | Lensed Fiber-Optic Two-Photon Endomicroscopy forField-of-View Enhancement | 期刊论文 | Conghao Wang;Huilan Liu;Jianrui Ma;Qiang Fu;Yijun Li;Yanchuan Chen;Yuqian Gao;Jingquan Tian;Xinlei Luo;Fei Yu;Chunzhu Zhao;Runlong Wu;Aimin Wang;Lishuang Feng |
| 15 | 活体固定装置 | 专利 | 吴润龙;王志刚;付强;田景全;王爱民;程和平 |
| 16 | Differential effects of social isolation on oligodendrocyte development in different brain regions: insights from a canine model | 期刊论文 | Huilin Hong;Chao Guo;Xueru Liu;Liguang Yang;Wei Ren;Hui Zhao;Yuan Li;Zhongyin Zhou;Sin Man Lam;Jidong Mi;Zhentao Zuo;Cirong Liu;Guo-Dong Wang;Yan Zhuo;Ya-Ping Zhang;Yixue Li;Guanghou Shui;Yong Q. Zhang;Ying Xiong |
| 17 | 一种用于评价犬认知能力的测试装置及方法 | 专利 | 米继东;赵建平;张永清;田瑞 |
| 18 | CHD8 mutations increase gliogenesis to enlarge brain size in the nonhuman primate | 期刊论文 | Bang Li;Hui Zhao;Zhuchi Tu;Weili Yang;Rui Han;Lu Wang;Xiaopeng Luo;Mingtian Pan;Xiusheng Chen;Jiawei Zhang;Huijuan Xu;Xiangyu Guo;Sen Yan;Peng Yin;Zhiguang Zhao;Jianrong Liu;Yafeng Luo;Yuefeng Li;Zhengyi Yang;Baogui Zhang;Zhiqiang Tan;Hao Xu;Tainzi Jiang;Yong-hui Jiang;Shihua Li;Yong Q. Zhang;Xiao-jiang Li |
| 19 | 一种测试笼装置及犬社交能力的评价方法 | 专利 | 米继东;赵建平;张永清;田瑞 |
| 20 | 一种动物组织切片装置 | 专利 | 洪慧琳;吴梁;张永清 |
| 21 | 一种用于评价犬运动能力的测试装置及方法 | 专利 | 米继东;赵建平;张永清;田瑞 |
| 22 | Miniature two-photon microscopy for enlarged field-of-view, multi-plane and long-term brain imaging | 期刊论文 | Weijian Zong;Runlong Wu;Shiyuan Chen;Junjie Wu;Hanbin Wang;Zhe Zhao;Guoqing Chen;Rui Tu;Danlei Wu;Yanhui Hu;Yangyang Xu;Yao Wang;Zhuoli Duan;Haitao Wu;Yunfeng Zhang;Jue Zhang;Aimin Wang;Liangyi Chen;Heping Cheng |
| 23 | Social isolation and the brain: effects and mechanisms | 期刊论文 | Ying Xiong;Huilin Hong;Cirong Liu;Yong Q. Zhang |
| 24 | 特异性靶向犬Rosa26基因的sgRNA及其应用 | 专利 | 石文文;张永清;吕雯 |
| 25 | The calcium-dependent protease calpain in neuronal remodeling and neurodegeneration | 期刊论文 | Elsayed Metwally;Guoli Zhao;Yong Q. Zhang |
| 26 | 生物信号检测设备 | 专利 | 吴梁;袁思琦;张永清 |
| 27 | 收纳装置及多光子显微镜设备 | 专利 | 吴润龙;云子艳;田景全;王爱民;程和平 |
| 28 | Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications | 期刊论文 | Hui Zhao;Jianping Zhao;Di Wu;Zhaolin Sun;Yang Hua;Min Zheng;Yumei Liu;Qi Yang;Xiahe Huang;Yuan Li;Yueshan Piao;Yingchun Wang;Sin Man Lam;Huijuan Xu;Guanghou Shui;Yongjun Wang;Haifeng Yao;Liangxue Lai;Zhuo Du;Jidong Mi;Enqi Liu;Xunming Ji;Yong Q. Zhang |
| 29 | 光学成像系统 | 专利 | 吴润龙;田景全;胡炎辉;王爱民;程和平 |
| 30 | Altered pupil responses to social and non-social stimuli in Shank3 mutant dogs | 期刊论文 | Wei Ren;Kang Huang;Yumo Li;Qin Yang;Liping Wang;Kun Guo;Pengfei Wei;Yong Q. Zhang |
| 31 | A high-resolution MRI brain template for adult Beagle | 期刊论文 | Xueru Liu;Rui Tian;Zhentao Zuo;Hui Zhao;Liang Wu;Yan Zhuo;Yong Q.Zhang;Lin Chen |
| 32 | 一种用于评价犬与犬社交能力的测试装置及方法 | 专利 | 米继东;赵建平;张永清;田瑞 |
| 33 | Two-photon endomicroscopy withmicrosphere-spliced double-claddingantiresonant fiber for resolution enhancement | 期刊论文 | CONGHAO WANG;HUILAN LIU;HAODONG CUI;JIANRUI MA;YIJUN LI;JINGQUAN TIAN;CHAOYONG JIN;YANCHUAN CHEN;YUQIAN GAO;QIANG FU;YANHUI HU;DAKUN WU;FEI YU;RUNLONG WU;AIMIN WANG;LISHUANG FENG |
| 34 | Miniature fluorescence microscopy for imaging brain activity in freely-behaving animals | 期刊论文 | Shiyuan Chen;Zichen Wang;Dong Zhang;Aiming Wang;Liangyi Chen;Heping Cheng;Runlong Wu |
| 35 | Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates | 期刊论文 | Hui Zhao;Qiqi Wang;Ting Yan;Yu Zhang;Hui-juan Xu;Hao-peng Yu;Zhuchi Tu;Xiangyu Guo;Yong-hui Jiang;Xiao-jiang Li;Huihui Zhou;Yong Q. Zhang |
| 36 | Spiral scanning fiber-optic two-photonendomicroscopy with a double-claddingantiresonant fiber | 期刊论文 | CONGHAO WANG;HUILAN LIU;JIANRUI MA;HAODONG CUI;YIJUN LI;DANLEI WU;YANHUI HU;DAKUN WU;QIANG FU;LINTANG LIANG;FEI YU;RUNLONG WU;AIMIN WANG;LISHUANG FENG |
| 37 | Gbb glutathionylation promotes its proteasome-mediated degradation to inhibit synapse growth | 期刊论文 | Md Shafayat Hossain;Aiyu Yao;Xinhua Qiao;Wenwen Shi;Ting Xie;Chang Chen;Yong Q. Zhang |
| 38 | Shank3 mutations enhance early neural responses to deviant tones in dogs | 期刊论文 | Liang Wu;Shuting Mei;Shan Yu;Shihui Han;Yong Q. Zhang |
| 39 | 一种饲养笼装置及犬运动能力的评价方法 | 专利 | 米继东;赵建平;张永清;田瑞 |
| 40 | 用于微型多光子显微镜的光学仪器及成像系统、成像方法 | 专利 | 赵春竹;王爱民;程和平 |
| 41 | Dog models of human atherosclerotic cardiovascular diseases | 期刊论文 | Hui Zhao;Enqi Liu;Yong Q. Zhang |
| 42 | 犬Rosa26基因及其应用 | 专利 | 石文文;张永清 |
| 43 | Femtosecond all-polarization-maintaining Ndfiber laser at 920 nm mode locked by a biasedNALM | 期刊论文 | SIYING WANG;YIJUN LI;YANCHUAN CHEN;YUQIAN GAO;ZHIGANG ZHANG;AIMIN WANG |
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