寨卡病毒感染导致小颅畸形的发病机制与防治研究
31730108
2017
C0902.发育与衰老神经生物学
许执恒
重点项目
研究员
中国科学院遗传与发育生物学研究所
324万元
小颅畸形;改进动物模型;发病机制;寨卡病毒感染
2018-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions | 期刊论文 | Ma Tiantian;Zhang Feng;Wang Yaqing;Xu Zhiheng |
| 2 | E90 subunit vaccine protects mice from Zika virus infection and microcephaly. | 期刊论文 | Zhu Xingliang;Li Chunfeng;Afridi Shabbir Khan;Zu Shulong;Xu Jesse W;Quanquin Natalie;Yang Heng;Cheng Genhong;Xu Zhiheng |
| 3 | cTAGE5 deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice. | 期刊论文 | Fan Junwan;Wang Yaqing;Liu Liang;Zhang Hongsheng;Zhang Feng;Shi Lei;Yu Mei;Gao Fei;Xu Zhiheng |
| 4 | Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children | 期刊论文 | Zhao Ziqi;Shang Ziwei;Vasconcelos Zilton;Li Chunfeng;Jiang Yisheng;Zu Shulong;Zhang Jingyi;Wang Fengchao;Yao Li;Jung Jae U.;Brasil Patricia;Moreira Maria Elisabeth;Qin Cheng-Feng;Kerin Tara;Nielsen-Saines Karin;Cheng Genhong;Zhang Xiaohui;Xu Zhiheng |
| 5 | POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function | 期刊论文 | Minghui Yao;Meizhen Meng;Xiyu Yang;Shuo Wang;Hongsheng Zhang;Feng Zhang;Lei Shi;Yongqing Zhang;Xiaohui Zhang;Zhiheng Xu |
| 6 | Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing | 期刊论文 | Zhao Ziqi;Zhang Dan;Yang Fuqiang;Xu Mingrui;Zhao Shaoli;Pan Taotao;Liu Chuanyu;Liu Yongjie;Wu Qingfeng;Tu Qiang;Zhou Ping;Li Rong;Kang Jia;Zhu Lan;Gao Fei;Wang Yaqing;Xu Zhiheng |
| 7 | Sh3rf2 Haploinsufficiency Leads to Unilateral Neuronal Development Deficits and Autistic-Like Behaviors in Mice. | 期刊论文 | Wang Shuo;Tan Ningdong;Zhu Xingliang;Yao Minghui;Wang Yaqing;Zhang Xiaohui;Xu Zhiheng |
| 8 | Treatment of SARS-CoV-2-induced pneumonia with NAD+ and NMN in two mouse models | 期刊论文 | Yisheng Jiang;Yong-Qiang Deng;Huanhuan Pang;Tiantian Ma;Qing Ye;Qi Chen;Haiyang Chen;Zeping Hu;Chengfeng Qin;Zhiheng Xu |
| 9 | SRPS associated protein WDR60 regulates the multipolar-to-bipolar transition of migrating neurons during cortical development. | 期刊论文 | Li Cui;Zheng Yu;Zheng Yufang;Xu Zhiheng |
| 10 | Intranasal Infection and Contact Transmission of Zika Virus in Guinea Pigs. | 期刊论文 | Deng Yong-Qiang;Zhang Na-Na;Li Xiao-Feng;Wang Ya-Qing;Tian Min;Qiu Ye-Feng;Fan Jun-Wan;Hao Jia-Nan;Huang Xing-Yao;Dong Hao-Long;Fan Hang;Wang Yu-Guang;Zhang Fu-Chun;Tong Yi-Gang;Xu Zhiheng;Qin Cheng-Feng |
| 11 | Disruption of glial cell development by Zika virus contributes to severe microcephalic newborn mice | 期刊论文 | Li Cui;Wang Qin;Jiang Yisheng;Ye Qing;Xu Dan;Gao Fei;Xu Jesse W.;Wang Ruoke;Zhu Xingliang;Shi Lei;Yu Lei;Zhang Fuchun;Guo Weixiang;Zhang Linqi;Qin Cheng-Feng;Xu Zhiheng |
| 12 | Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model | 期刊论文 | Chang Yafei;Jiang Yisheng;Li Cui;Wang Qin;Zhang Feng;Qin Cheng-Feng;Wu Qing-Feng;Li Jing;Xu Zhiheng |
| 13 | Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids | 期刊论文 | Xu Yan Peng;Qiu Yang;Zhang Boya;Chen Guilai;Chen Qi;Wang Miao;Mo Fan;Xu Jiuyue;Wu Jin;Zhang Rong Rong;Cheng Meng Li;Zhang Na Na;Lyu Bao;Zhu Wen Liang;Wu Meng Hua;Ye Qin;Zhang Da;Man Jiang Hong;Li Xiao Feng;Cui Jie;Xu Zhiheng;Hu Baoyang;Zhou Xi;Qin Cheng Feng |
| 14 | American Strain of Zika Virus Causes More Severe Microcephaly than an Old Asian Strain in neonatal Mice. | 期刊论文 | Zhang Feng;Wang Hong-Jiang;Wang Qin;Liu Zhong-Yu;Yuan Ling;Huang Xing-Yao;Li Guanghui;Ye Qing;Yang Haozhen;Shi Lei;Deng Yong-Qiang;Qin Cheng-Feng;Xu Zhiheng |
| 15 | A single mutation in the prM protein of Zika virus contributes to fetal microcephaly | 期刊论文 | Yuan Ling;Huang Xing-Yao;Liu Zhong-Yu;Zhang Feng;Zhu Xing-Liang;Yu Jiu-Yang;Ji Xue;Xu Yan-Peng;Li Guanghui;Li Cui;Wang Hong-Jiang;Deng Yong-Qiang;Wu Menghua;Cheng Meng-Li;Ye Qing;Xie Dong-Yang;Li Xiao-Feng;Wang Xiangxi;Shi Weifeng;Hu Baoyang;Shi Pei-Yong;Xu Zhiheng;Qin Cheng-Feng |
| 16 | MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis. | 期刊论文 | Xu Dan;Yao Minghui;Wang Yaqing;Yuan Ling;Hoeck Joerg D;Yu Jingwen;Liu Liang;Yeap Yvonne Y C;Zhang Weiya;Zhang Feng;Feng Yinghang;Ma Tiantian;Wang Yujie;Ng Dominic C H;Niu Xiaoyin;Su Bing;Behrens Axel;Xu Zhiheng |
| 17 | cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development. | 期刊论文 | Zhang Feng;Wang Yaqing;Wang Tao;Yao Li;Lam Sin Man;Huang Xiahe;Fan Junwan;Wang Qin;Liu Liang;Jiang Yisheng;Zhang Hongsheng;Shi Lei;Yu Mei;Shui Guanghou;Wang Yingchun;Gao Fei;Zhang Xiaohui;Xu Zhiheng |
| 18 | Update on the Animal Models and Underlying Mechanisms for ZIKV-Induced Microcephaly. | 期刊论文 | Xu Dan;Li Cui;Qin Chengfeng;Xu Zhiheng |
| 19 | Aberrant NAD(+) metabolism underlies Zika virus-induced microcephaly | 期刊论文 | Pang Huanhuan;Jiang Yisheng;Li Jie;Wang Yushen;Nie Meng;Xiao Nan;Wang Shuo;Song Zhihong;Ji Fansen;Chang Yafei;Zheng Yu;Yao Ke;Yao LiAng;Li Shao;Li Peng;Song Lei;Lan Xun;Xu Zhiheng;Hu Zeping |
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