基于体内过程的调节糖脂代谢紊乱中药“味-功效物质-生物学”的基础研究

81430095
2014
H3203.中药药效物质
邱峰
重点项目
教授
天津中医药大学
320万元
糖脂代谢;五味;中药药效物质;体内代谢产物;作用机制
2015-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
重置
序号 标题 类型 作者
1 Six New Methyl Apiofuranosides from the Bark of Phellodendron chinense Schneid and Their Inhibitory Effects on Nitric Oxide Production 期刊论文 Pengfei Wang;Yanping Li;Liqin Ding;Shijie Cao;Lining Wang;Feng Qiu
2 Integrated Systems Biology and Chemical Biology Approach to Exploring Mechanisms of Traditional Chinese Medicines 期刊论文 Gang Bai;Yuan-yuan Hou;Min Jiang;Jie Gao
3 Chemomics-Integrated Proteomics Analysis of Jie-Geng-Tang to Ameliorate Lipopolysaccharide-Induced Acute Lung Injury in Mice 期刊论文 Jin Tao;Yan Nie;Yuanyuan Hou;Xiaoyao Ma;Guoyu Ding;Jie Gao;Min Jiang;Gang Bai
4 魏察酸浆苦素Y及提取方法及用途 专利 邱峰;孙成鹏;赵烽;陈丽霞;康宁
5 Identification of absorbed constituents and in vivo metabolites in rats after oral administration of Physalis alkekengi var. franchetii by ultrahigh-pressure liquid chromatography quadrupole time-of-flight mass spectrometry 期刊论文 Xinchi Feng;Xiaoguang Huo;Hongxia Liu;Liwei Chai;Liqin Ding;Feng Qiu
6 A new phenone from the roots of Paeonia suffruticosa Andrews. 期刊论文 Liqin Ding;Qingfei Zuo;Dandan Li;Xinchi Feng;Xiumei Gao;Feng Zhao;Feng Qiu
7 Biodistribution of arctigenin-loaded nanoparticles designed for multimodal imaging 期刊论文 Qingxin Cui;Yuanyuan Hou;Yanan Wang;Xu Li;Yang Liu;Xiaoyao Ma;Zengyong Wang;Weiya Wang;Jin Tao;Qian Wang;Min Jiang;Dongyan Chen;Xizeng Feng;Gang Bai
8 Four new sesquiterpenes from the rhizomes of Curcuma phaeocaulis and their iNOS inhibitory activities 期刊论文 Jianghao Ma;Ying Wang;Yue Liu;Suyu Gao;Liqin Ding;Feng Zhao;Lixia Chen;Feng Qiu
9 Four new sesquiterpenoids as natural nitric oxide (NO) inhibitors from the rhizomes of Curcuma phaeocaulis 期刊论文 Jianghao Ma;Feng Zhao;Ying Wang;Yue Liu;Suyu Gao;Liqin Ding;Lixia Chen;Feng Qiu
10 Metabolic profiles of corydaline in rats by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry 期刊论文 Liwei Chai;Paul Owusu Donkor;Kun Wang;Yingjie Sun;Mahmood Brobbey Oppong;Kai Wang;Liqin Ding;Feng Qiu
11 Metabolites identification of berberine in rats using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry 期刊论文 Kun Wang;Liwei Chai;Xinchi Feng;Zhongbo Liu;Hongxia Liu;Liqin Ding;Feng Qiu
12 基于UPLC-MS/MS的芍药苷及其代谢产物在大鼠体内药动学研究 期刊论文 霍晓光;王琨;冯心池;丁丽琴;邱峰
13 Isolation, structural elucidation and in vitro hepatoprotective activity of flavonoids from Glycyrrhiza uralensis 期刊论文 Ming Cheng;Liqin Ding;Hongfeng Kan;Hongmin Zhang;Benke Jiang;Yingjie Sun;Shijie Cao;Wei Li;Kazuo Koike;Feng Qiu
14 Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD) 期刊论文 Qian Chen;Tingting Wang;Jian Li;Sijian Wang;Feng Qiu;Haiyang Yu;Yi Zhang;Tao Wang
15 Metabolic profiling of quercetin in rats using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry 期刊论文 Mingjiang Wu;Xiaolei Wu;Deqin Zhang;Feng Qiu;Liqin Ding;Haoling Ma;Xinze Chen
16 A rapid integrated bioactivity evaluation system based onnear-infrared spectroscopy for quality control of Flos Chrysanthemi 期刊论文 Guoyu Ding;Baiqing Li;Yanqi Han;Aina Liu;Jingru Zhang;Jiamin Peng;Min Jiang;Yuanyuan Hou;Gang Bai
17 一种睡茄交酯类化合物及提取方法及应用 专利 邱峰;孙成鹏;陈丽霞;康宁
18 Potential drug interactions associated with glycyrrhizin and glycyrrhetinic acid 期刊论文 Xinchi Feng;Liqin Ding;Feng Qiu
19 UPLC-MS/MS法同时测定大鼠血浆中赤芍提取物三种单萜类成分及其药代动力学研究 期刊论文 陈新则;马浩玲;丁丽琴;张德芹;吴晓磊;伍明江;邱峰
20 睡茄交酯类化合物及提取方法及应用 专利 邱峰;孙成鹏;陈丽霞;康宁
21 Cadinane sesquiterpenes from Curcuma phaeocaulis with their inhibitory activities on nitric oxide production in RAW 264.7 cells 期刊论文 Jianghao Ma;Ying Wang;Yue Liu;Suyu Gao;Liqin Ding;Feng Zhao;Lixia Chen;Feng Qiu
22 基于中药性味理论和网络药理学方法的治疗消渴方药作用机制研究 期刊论文 陶瑾;姜民;陈露莹;侯媛媛;张德芹;邱峰;白钢
23 Ursolic acid, a natural nutraceutical agent target to caspase3 alleviates inflammatory associated downstream signal transduction process 期刊论文 Xiaoyao Ma;Yuan Zhang;Zengyong Wang;Yunbing Shen;Man Zhang;Quandeng Nie;Yuanyuan Hou;Gang Bai
24 黄芩非黄酮类成分研究 期刊论文 许剑侠;丁丽琴;姜苗苗;邱峰
25 Phillygenin, a lignan compound, inhibits hypertension by reducing PLCβ3-dependent Ca2+ oscillation 期刊论文 Wenjuan Liu;Yanting Jiao;Fukui Shen;Zhihua Wang;Lili Ye;Yuanyuan Hou;Gang Bai
26 睡茄交酯类化合物及提取方法及用途 专利 邱峰;孙成鹏;陈丽霞;赵烽;康宁;丁丽琴
27 辛味中药在治疗消渴症(糖尿病)中的应用价值及中药五味理论现代化研究的思考 期刊论文 李盼;陈雨微;丁丽琴;曹世杰;张德芹;张伯礼;邱峰
28 LC-MS/MS method for simultaneous determination of flavonoids and physalins in rat plasma: Application to pharmacokinetic study after oral administration of Physalis alkekengi var. franchetii (Chinese lantern) extract 期刊论文 Yaqing Guo;Hongxia Liu;Liqin Ding;Mahmood Oppong;Guixiang Pan;Feng Qiu
29 苦蘵苦素I及提取方法及用途 专利 邱峰;孙成鹏;陈丽霞;康宁
30 Rh2(OCOCF3)4试剂在仲醇和叔醇类结构绝对构型确定中的应用 期刊论文 夏桂阳;王萌;陈丽霞;丁丽琴;邱峰
31 Chlorogenic Acid Targeting of the AKT-PH Domain Activates AKT-GSK3β/FOXO1 Signaling and Improves Glucose/Lipid Metabolism 期刊论文 Jie Gao;Xin He;Yuejiao Ma;Xuezhi Zhao;Xiaotao Hou;Erwei Hao;Jiagang Deng;Gang Bai
32 Locally and traditionally used Ligusticum species-A review of their phytochemistry, pharmacology and pharmacokinetics 期刊论文 Paul Owusu Donkor;Ying Chen;Liqin Ding;Feng Qiu
33 Two pairs of phenylpropanoid enantiomers from the leaves of Eucommia ulmoides 期刊论文 Xuliu Shi;Jiankun Yan;Wenkai Li;Paul Owusu Donkor;Xiumei Gao;Liqin Ding;Feng Qiu
34 Four novel bisabolane-type sesquiterpenes from Curcuma longa 期刊论文 Jing Wen;Tianyi Qiu;Xinjia Yan;Feng Qiu
35 Systematic characterization of the metabolites of paeonol in rats using ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry with an integrative strategy 期刊论文 Liqin Ding;Tianyi Qiu;Zhaoxin Liu;Lixia Chen;Mahmood Brobbey Oppong;Deqin Zhang;Boli Zhang;Gang Bai;Feng Qiu
36 Metabolic profiling of nuciferine in rat urine, plasma, bile and feces after oral administration using ultra-high performance liquid chromatography-diode array detection-quadrupole time-of-flight mass spectrometry 期刊论文 Xiaolei Wu;Mingjiang Wu;Xinze Chen;Haoling Ma;Liqin Ding;Feng Qiu
37 9-O-benzoyl-substituted berberine exerts a triglyceride-lowering effect through AMPK signaling pathway in human hepatoma HepG2 cells 期刊论文 Shijie Cao;Shengyang Yu;Lina Cheng;Jiankun Yan;Yan Zhu;Yanru Deng;Feng Qiu
38 丹皮酚及其体内代谢产物的新用途 专利 丁丽琴;邱峰;李巍;胡欣彤;姜本科;程丽娜
39 一种能改善细胞膜通透性的桔梗次生皂苷的制备方法 专利 白钢;姜志宏;侯媛媛;王静荣;吴文博;唐仲尧;申福葵;张曼;姜民;高洁
40 Withapubesides A-D: natural inducible nitric oxide synthase (iNOS) inhibitors from Physalis pubescens 期刊论文 Guiyang Xia;Tie Yao;Bingyang Zhang;Yang Li;Ning Kang;Shijie Cao;Liqin Ding;Lixia Chen;Feng Qiu
41 Baicalin and its metabolites suppresses gluconeogenesis through activation of AMPK or AKT in insulin resistant HepG-2 Cells 期刊论文 Tao Wang;Hongmei Jiang;Shijie Cao;Qian Chen;Mingyuan Cui;Zhijie Wang;Dandan Li;Jing Zhou;Tao Wang;Feng Qiu;Ning Kang
42 Identification of Target Proteins of Mangiferin in Mice with Acute Lung Injury Using Functionalized Magnetic Microspheres Based on Click Chemistry 期刊论文 Jiajia Wang;Yan Nie;Yunjuan Li;Yuanyuan Hou;Wei Zhao;Jiagang Deng;Peng George Wang;Gang Bai
43 荜茇明宁碱在制备sEH抑制剂中的应用 专利 刘中博;邱峰
44 Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cells. 期刊论文 Shijie Cao;Peixiang Xu;Jiankun Yan;Hui Liu;Lu Liu;Lina Cheng;Feng Qiu;Ning Kang
45 甘草主要成分改善L6大鼠成肌细胞胰岛素抵抗的机制研究 期刊论文 程丽娜;曹世杰;曲明;邱峰;康宁
46 Identification of berberrubine metabolites in rats by using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry 期刊论文 Kun Wang;Miao Qiao;Liwei Chai;Shijie Cao;Xinchi Feng;Liqin Ding;Feng Qiu
47 Identification of metabolites of palmatine in rats after oral administration using ultra‐high‐performance liquid chromatography/quadrupole time‐of‐flight mass spectrometry 期刊论文 Kun Wang;Liwei Chai;Liqin Ding;Feng Qiu
48 Insights into the intestinal bacterial metabolism of flavonoids and the bioactivities of their microbe-derived ring cleavage metabolites 期刊论文 Xinchi Feng;Yang Li;Mahmood Brobbey Oppong;Feng Qiu
49 一种小檗红碱固体分散体粉末及制备方法及应用 专利 邱峰;刘志东;祁东利;马丽;李佳玮;丁丽琴
50 New hepatoprotective isoflavone glucosides from Pueraria lobata (Willd.) Ohwi 期刊论文 Yingjie Sun;Hongmin Zhang;Ming Cheng;Shijie Cao;Miao Qiao;Boli Zhang;Liqin Ding;Feng Qiu
51 Natural nitric oxide (NO) inhibitors from the rhizomes of Curcuma phaeocaulis 期刊论文 Jianghao Ma;Feng Zhao;Ying Wang;Yue Liu;Suyu Gao;Liqin Ding;Li-Xia Chen;Feng Qiu
52 Comparison and evaluation of antimuscarinic and anti-inflammatory effects of five Bulbus fritillariae species based on UPLC-Q/TOF integrated dual-luciferase reporter assay, PCA and ANN analysis 期刊论文 Mengge Zhou;Xiaoyao Ma;Guoyu Ding;Zengyong Wang;Dan Liu;Yongling Tong;Hong Zhou;Jie Gao;Yuanyuan Hou;Min Jiang;Gang Bai
53 (+)/(-)-Phaeocaulin A-D, four pairs of new enantiomeric germacrane-type sesquiterpenes from Curcuma phaeocaulis as natural nitric oxide inhibitors 期刊论文 Guiyang Xia;Dejuan Sun;Jianghao Ma;Jianghao Ma;Feng Zhao;Paul Owusu Donkor;Liqin Ding;Lixia Chen;Feng Qiu
54 大鼠灌胃牡丹皮提取物后丹皮酚及其代谢产物的药代动力学研究 期刊论文 胡欣彤;丁丽琴;李巍;邱峰
55 Phytochemical constituents from Scutellaria baicalensis in soluble epoxide hydrolase inhibition: Kinetics and interaction mechanism merged with simulations. 期刊论文 Zhong-Bo Liu;Cheng-Peng Sun;Jian-Xia Xu;Christophe Morisseau;Bruce D. Hammock;Feng Qiu
56 Discovery and identification of quality markers of Chinese medicine based on pharmacokinetic analysis. 期刊论文 Jun He;Xinchi Feng;Kai Wang;Changxiao Liu;Feng Qiu
57 Metabolic profiling of icariin in rat feces, urine, bile and plasma after oral administration using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry. 期刊论文 Tong Wang;Xinchi Feng;Liqin Ding;Kun Wang;Miao Qiao;Liwei Chai;Yang Li;Feng Qiu
58 Two pairs of farnesyl phenolic enantiomers as natural nitric oxide inhibitors from Ganoderma sinense 期刊论文 Meng Wang;Fei Wang;Feng Xu;Liqin Ding;Qian Zhang;Huixiang Li;Feng Zhao;Liqing Wang;Lihan Zhu;Lixia Chen;Feng Qiu
59 UPLC-Q-TOF/MS鉴定大鼠口服桑叶黄酮后的体内物质 期刊论文 伍明江;吴晓磊;张德芹;丁丽琴;邱峰;马浩玲;陈新则
60 治疗高脂血症上市中成药的处方规律研究 期刊论文 马浩玲;张德芹;丁丽琴;陈新则;伍明江;吴晓磊;邱峰
61 杜仲皮化学成分研究 期刊论文 黄卫星;姚铁;丁丽琴;李巍
62 海蒿子含氮有机化学成分研究 期刊论文 李丹丹;丁丽琴;杨灵;邱峰
63 Glycyrrhetinic acid improves insulin resistance by regulating the balance between the Ras/MAPK and PI3K/Akt pathways. 期刊论文 Yuan Zhang;Shengnan Yang;Man Zhang;Zhihua Wang;Xin He;Yuanyuan Hou;Gang Bai
64 Metabolic profiling of Luteolin-7-O-glucoside in rat urine, plasma, bile and feces after oral administration using ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry 期刊论文 Hongxia Liu;Xiaoguang Huo;Liqin Ding;Xinchi Feng;Miaomiao Jiang;Guixiang Pan;Lixia Chen;Feng Qiu
65 The flavonoid baicalin improves glucose metabolism by targeting the PH domain of AKT and activating AKT/GSK3β phosphorylation 期刊论文 Shengnan Yang;Yuan Zhang;Fukui Shen;Xiaoyao Ma;Man Zhang;Yuanyuan Hou;Gang Bai
66 Natural Product Puerarin Activates Akt and Ameliorates Glucose and Lipid Metabolism Dysfunction in Hepatic Cells 期刊论文 Yuan Zhang;Zhihua Wang;Xiaoyao Ma;Sengnan Yang;Xueyan Hu;Yuanyuan Hou;Gang Bai
67 一种以忍冬属植物为原料制备高纯度绿原酸的方法 专利 白钢;侯媛媛;王彦帅
68 Simultaneous determination of five isoflavones in rat plasma by LC-MS/MS: comparative pharmacokinetic characteristics of Puerariae lobatae radix in normal and type 2 diabetic rats 期刊论文 Hongmin Zhang;Xintong Hu;Miao Qiao;Yang Li;Shijie Cao;Liqin Ding;Xinchi Feng;Ning Kang;Deqin Zhang;Feng Qiu
69 Two pairs of phenolic enantiomers from the leaves of Eucommia ulmoides Oliver 期刊论文 Jiankun Yan;Xuliu Shi;Paul Owusu Donkor;Xiumei Gao;Liqin Ding;Feng Qiu
70 调节糖脂代谢的苦味中药的化学及生物学研究 期刊论文 卢方晋;丁丽琴;曹世杰;张德芹;张伯礼;邱峰
71 治疗糖尿病上市中成药处方规律研究 期刊论文 陈新则;马浩玲;丁丽琴;张德芹;吴晓磊;伍明江
72 Rapid characterization of the absorbed chemical constituents of Tangzhiqing formula following oral administration using UHPLC-Q-TOF-MS 期刊论文 Xiaolei Wu;Mingjiang Wu;Xinze Chen;Hongmin Zhang;Liqin Ding;Fuying Tian;Xiaomeng Fu;Feng Qiu;Deqin Zhang
73 A novel withanolide with an unprecedented carbon skeleton from Physalis angulate 期刊论文 Chengpeng Sun;Andrei G. Kutateladze;Feng Zhao;Lixia Chen;Feng Qiu
74 Anti-inflammatory labdane-type diterpenoids from Physalis angulate 期刊论文 Chengpeng Sun;Ting Yuan;Lei Wang;Ning Kang;Feng Zhao;Lixia Chen;Feng Qiu
75 Physalins V-IX, 16,24-cyclo-13,14-seco withanolides from Physalis angulata and their antiproliferative and anti-inflammatory activities 期刊论文 Chengpeng Sun;Chongyue Qiu;Feng Zhao;Ning Kang;Lixia Chen;Feng Qiu
76 Nine pairs of megastigmane enantiomers from the leaves of Eucommia ulmoides 期刊论文 Jiankun Yan;Xuliu Shi;Paul Owusu Donkor;Huajie Zhu;Xiumei Gao;Liqin Ding;Feng Qiu
77 通过检测当归药材中具有钙拮抗功效的有效成分含量评价质量等级的方法 专利 白钢;姜民;侯媛媛;闫孟琳;丁国钰;丛龙飞;高洁;牛瑞雪
78 Natural Product Puerarin Activates Akt and Ameliorates Glucose and Lipid Metabolism Dysfunction in Hepatic Cells 期刊论文 Yunbing Shen;Shengnan Yang;Xueyan Hu;Man Zhang;Xiaoyao Ma;Zhihua Wang;Yuanyuan Hou;Gang Bai
79 莪术烯醇微生物转化衍生物及其制备方法和用途 专利 陈丽霞;邱峰;赵烽;赵倩;梁艳艳;张萌
80 Four new megastigmane glycosides from the leaves of Eucommia ulmoides Oliver 期刊论文 Jiankun Yan;Xuliu Shi;Paul Owusu Donkor;Liqin Ding;Feng Qiu
81 黄柏非生物碱化学成分研究 期刊论文 李艳萍;李丹丹;丁丽琴;邱峰
82 Characterization of the In Vivo and In Vitro Metabolites of Linarin in Rat Biosamples and Intestinal Flora Using Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Tandem Mass Spectrometry. 期刊论文 Xinchi Feng;Yang Li;Chenxi Guang;Miao Qiao;Tong Wang;Liwei Chai;Feng Qiu
83 Genipin, a natural AKT inhibitor, targets the PH domain to signaling and alleviates inflammation. 期刊论文 Yanting Jiao;Fukui Shen;Zhihua Wang;Lili Ye;Yuanyuan Hou;Gang Bai
84 Metabolic profiles of physalin A in rats using ultra-high performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry 期刊论文 Xinchi Feng;Hongxia Liu;Liwei Chai;Liqin Ding;Guixiang Pan;Feng Qiu
85 Scutellaria baicalensis regulates FFA metabolism to ameliorate NAFLD through the AMPK mediated SREBP signaling pathway. 期刊论文 Qian Chen;Mengyang Liu;Haiyang Yu;Jian Li;Sijian Wang;Yi Zhang;Feng Qiu;Tao Wang
86 一种莪术烯醇的微生物转化产物的制备方法及其用途 专利 陈丽霞;邱峰;赵烽;赵倩
87 Phillygenin attenuates inflammatory responses and influences glucose metabolic parameters by inhibiting Akt activity 期刊论文 Wenjuan Liu;Guangcui Chu;Nianwei Chang;Xiaoyao Ma;Jiang Min;Bai Gang
88 HPLC-MS/MS法同时测定大鼠血浆中山楂叶提取物三种黄酮类成分及其药代动力学研究 期刊论文 马浩玲;张德芹;丁丽琴;陈新则;吴晓磊;伍明江;邱峰
89 The metabolism of berberine and its contribution to the pharmacological effects 期刊论文 Kun Wang;Xinchi Feng;Xinchi Feng;Liwei Chai;Shijie Cao;Feng Qiu
90 Two Sulfonate Metabolites of Physalin A in Rats 期刊论文 Hongxia Liu;Kun Wang;Guiyang Xia;Kai Wang;Liwei Chai;Paul Owusu Donkor;Liqin Ding;Feng Qiu
91 染料木素对油酸诱导HepG2细胞脂质蓄积的影响 期刊论文 张洪敏;曹世杰;何欣雅;邱峰;张德芹
92 Flavonoids from Eucommia ulmoides and their in vitro hepatoprotective activities 期刊论文 黄卫星;丁丽琴;张楠;李巍;Kazuo Koike;邱峰
93 UPLC-Q-TOF/MS鉴定芦丁在大鼠体内的代谢产物 期刊论文 伍明江;吴晓磊;张德芹;丁丽琴;邱峰;张洪敏
查看更多信息请先登录或注册