中药升麻环菠萝蜜烷三萜类成分基于内质网应激途径诱导肝癌细胞凋亡的活性和作用机制的研究

81373953
2013
H3203.中药药效物质
陈四保
面上项目
研究员
中国医学科学院药用植物研究所
70万元
肝癌;内质网应激;升麻;环菠萝蜜烷三萜;非折叠蛋白反应
2014-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Centipeda minima (Ebushicao) extract inhibits PI3K-Akt-mTOR signaling in nasopharyngeal carcinoma CNE-1 cells 期刊论文 Guo Yu-qing;Sun Hai-yan;Chan Chi-on;Liu Bei-bei;Wu Jian-hong;Chan Shun-wan;Mok Daniel Kam-Wah;Tse Anfernee Kai-Wing;Yu Zhi-ling;Chen Si-bao
2 升麻中环菠萝蜜烷三萜化学成分及其抗肿瘤活性的研究 期刊论文 孙海燕;刘蓓蓓;陈四保
3 Novel cycloartane triterpenoid from Cimicifuga foetida (Sheng ma) induces mitochondrial apoptosis via inhibiting Raf/MEK/ERK pathway and Akt phosphorylation in human breast carcinoma MCF-7 cells 期刊论文 Sun Hai-yan;Liu Bei-bei;Hu Jian-yang;Xu Li-jia;Chan Shun-wan;Chan Chi-on;Mok Daniel K. W.;Zhang Dong-mei;Ye Wen-cai;Chen Si-bao
4 Enhanced intestinal permeability of bufalin by a novel bufalin-peptide-dendrimer inclusion through Caco-2 cell monolayer 期刊论文 Chi-on Chan;Jing Jing;Wei Xiao;Zhexu Tan;Qiuyue Lv;Jingyu Yang;Sibao Chen
5 The cycloartane triterpenoid ADCX impairs autophagic degradation through Akt overactivation and promotes apoptotic cell death in multidrug-resistant HepG2/ADM cells. 期刊论文 Haiyan Sun;Maohua Huang;Nan Yao;Jianyang Hu;Yingjie Li;Liping Chen;Nan Hu;Wencai Ye;Dongmei Zhang;Sibao Chen
6 Petroleum ether extractive of the hips of Rosa multiflora ameliorates collage 期刊论文 Jianhong Wu; Xingxian Liu; Chi-on Chan; Daniel K. W. Mok; Shun-wan Chan; Zhiling Yu; Sibao Chen
7 Comparative Evaluation of Chemical Profiles of Pyrrosiae Folium Originating from Three Pyrrosia Species by HPLC-DAD Combined with Multivariate Statistical Analysis 期刊论文 Wei Xiao;Yude Peng;Zhexu Tan;Qiuyue Lv;Chi-on Chan;Jingyu Yang;Sibao Chen
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