CD39-CD73-腺苷通路调控酒精性肝纤维化HSC活化增殖的作用及机制

81970518
2019
H0308.药物、毒物及酒精性消化系统疾病
吕雄文
面上项目
教授
安徽医科大学
53万元
胞外核苷酸酶;酒精性肝病;酒精性肝纤维化;肝星状细胞;嘌呤信号转导
2020-01-01到2023-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 CD73 mitigates hepatic damage in alcoholic steatohepatitis by regulating PI3K/AKT-mediated hepatocyte pyroptosis 期刊论文 Zhu H;Zhang M;Ye Y;Liu Z;Wang J;Wu X;Lv X
2 Purine signaling regulating HSCs inflammatory cytokines secretion, activation, and proliferation plays a critical role in alcoholic liver disease 期刊论文 Shan L;Jiang T;Ci L;Liu Z;Lv X;Li J
3 CD73-Adenosine A1R Axis Regulates the Activation and Apoptosis of Hepatic Stellate Cells Through the PLC-IP3-Ca2+/DAG-PKC Signaling Pathway 期刊论文 Liu Z;Wu X;Wang Q;Li Z;Liu X;Sheng X;Zhu H;Zhang M;Xu J;Feng X;Wu B;Lv X
4 咖啡因介导腺苷信号通路调控酒精性肝纤维化作用机制及新靶点发掘 奖励 吕雄文;张磊;杨雅茹;黄成;代雪飞
5 CD73/NT5E-mediated ubiquitination of AURKA regulates alcohol-related liver fibrosis via modulating hepatic stellate cell senescenc 期刊论文 Liu Z;Wu B;Liu X;Wu X;Du J;Xia G;Cai J;Zhu H;Sheng X;Zhang M;Xu J;Xu T;Lv X
6 CD73 aggravates alcohol-related liver fibrosis by promoting autophagy mediated activation of hepatic stellate cells through AMPK/AKT/mTOR signaling pathway 期刊论文 Wu X;Liu XQ;Liu ZN;Xia GQ;Zhu H;Zhang MD;Wu BM;Lv XW
7 The role of the CD39-CD73-adenosine pathway in liver disease 期刊论文 Wang S;Gao S;Zhou D;Qian X;Luan J;Lv X
8 The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD39 期刊论文 Xia GQ;Cai JN;Wu X;Fang Q;Zhao N;Lv XW
9 CD73 Attenuates Alcohol-Induced Liver Injury and Inflammation via Blocking TLR4/MyD88/NF-κB Signaling Pathway 期刊论文 Liu ZN;Wu X;Fang Q;Li ZX;Xia GQ;Cai JN;Lv XW
10 CD73 regulates hepatic stellate cells activation and proliferation through Wnt/β-catenin signaling pathway 期刊论文 Jia WQ;Zhou TC;Dai JW;Liu ZN;Zhang YF;Zang DD;Lv XW
11 Blocking P2X4 purinergic receptor attenuates alcohol-related liver fibrosis by inhibiting hepatic stellate cell activation through PI3K/AKT signaling pathway 期刊论文 Li ZX;Sheng XD;Wang YL;Wen Lv X
12 Inhibition of P2Y6 receptor expression in Kupffer cells alleviates alcoholic steatohepatitis in mice 期刊论文 Yuan F;Cai JN;Dai M;Lv X
13 CD39-mediated ATP-adenosine signalling promotes hepatic stellate cell activation and alcoholic liver disease. 期刊论文 Shuai C;Xia GQ;Yuan F;Wang S;Lv XW
14 Adenosine receptor A2B mediates alcoholic hepatitis by regulating cAMP levels and the NF-KB pathway 期刊论文 Zhao N;Xia G;Cai J;Li Z;Lv XW
15 CD39-腺苷能轴在纤维化疾病中作用的研究进展 期刊论文 帅陈;慈雷雷;贾文茜;吕雄文
16 P2X7 Receptor in Alcoholic Steatohepatitis and Alcoholic Liver Fibrosis 期刊论文 Xia GQ;Fang Q;Cai JN;Li ZX;Zhang FZ;Lv XW
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