清除癌症干细胞天然产物JBIR-141的全合成与构效关系研究
81703343
2017
H3401.合成药物化学
杨光
青年科学基金项目
副研究员
南开大学
21万元
癌症干细胞;构效关系研究;JBIR-141;全合成;分子探针
2018-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | alpha-Alkylation of Chiral Sulfinimines for Constructing Quaternary Chiral Carbons by Introducing Removable Directing Groups | 期刊论文 | Qin Shuanglin;Liu Shuangwei;Cao Yuting;Li Jiangnan;Chong Chuanke;Liu Tongtong;Luo Yunhao;Hu Jiyun;Jiang Shende;Zhou Honggang;Yang Guang;Yang Cheng |
| 2 | Synthesis and discovery of a drug candidate for treatment of idiopathic pulmonary fibrosis through inhibition of TGF-beta 1 pathway | 期刊论文 | Li Xiaohe;Lu Cheng;Liu Shuangwei;Liu Shuaishuai;Su Chengcheng;Xiao Ting;Bi Zhun;Sheng Pengzhen;Huang Mengying;Liu Xinhua;Wei Yujiao;Zhao Lin;Miao Shengxiang;Mao Jiahe;Huang Kai;Gao Shaoyan;Liu Ning;Qi Min;Liu Tongtong;Qin Shuanglin;Wei Luqing;Sun Tao;Ning Wen;Yang Guang;Zhou Honggang;Yang Cheng |
| 3 | Rh-Catalyzed diastereo- and linear-selective alpha-allylation of chiral cycloenamines | 期刊论文 | Wang Xiaoji;Luo Yunhao;Qin Shuanglin;Sun Yue;Wang Ning;Yan Jun;Yang Guang |
| 4 | A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/beta-catenin signaling pathway | 期刊论文 | Liu Shuangwei;Gao Xian;Zhang Lisong;Qin Shuanglin;Wei Mingming;Liu Ning;Zhao Rui;Li Benlong;Meng Ye;Lin Gang;Lu Cheng;Liu Xinhua;Xie Maodun;Liu Tongtong;Zhou Honggang;Qi Min;Yang Guang;Yang Cheng |
| 5 | Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer | 期刊论文 | Wei Mingming;Xie Maodun;Zhang Zhen;Wei Yujiao;Zhang Juan;Pan Hongli;Li Benlong;Wang Jingjing;Song Yang;Chong Chuangke;Zhao Rui;Wang Jiefu;Yu Li;Yang Guang;Yang Cheng |
| 6 | Synthesis of enantiopure F-18-trifluoromethyl cysteine as a structure-mimetic amino acid tracer for glioma imaging | 期刊论文 | Liu Shaoyu;Ma Hui;Zhang Zhanwen;Lin Liping;Yuan Gongjun;Tang Xiaolan;Nie Dahong;Jiang Shende;Yang Guang;Tang Ganghua |
| 7 | First orally bioavailable prodrug of proteolysis targeting chimera (PROTAC) degrades cyclin-dependent kinases 2/4/6 in vivo. | 期刊论文 | Wei Mingming;Zhao Rui;Cao Yuting;Wei Yujiao;Li Ming;Dong Zhiqiang;Liu Yulin;Ruan Hao;Li Ying;Cao Sheng;Tang Zhiwen;Zhou Yuanyuan;Song Wei;Wang Yubo;Wang Jiefu;Yang Guang;Yang Cheng |
| 8 | Diastereoselective Rh-catalyzed decarboxylative allylation to form quaternary stereocenters using sulfinimine as the directing group | 期刊论文 | Qin Shuanglin;Liu Tongtong;Luo Yunhao;Jiang Shende;Yang Guang |
| 9 | 五环三萜衍生物及其制备方法、药物组合物和用途 | 专利 | 杨诚;杨光;周红刚;孙涛 |
| 10 | Iron/copper co-catalyzed highly selective arylation of sulfinamides with aryl iodides | 期刊论文 | Qin Shuanglin;Luo Yunhao;Sun Yue;Tian Le;Jiang Shende;Yan Jun;Yang Guang |
| 11 | An Efficient Method for Constructing Cyclic -Amino Acids Bearing Quaternary Stereocenters | 期刊论文 | Qin Shuanglin;Liu Tongtong;Luo Yunhao;Yan Jun;Kang Hong;Jiang Shende;Yang Guang |
| 12 | Design and synthesis of Leukotriene A4 hydrolase inhibitors to alleviate idiopathic pulmonary fibrosis and acute lung injury | 期刊论文 | Li Xiaohe;Xie Maodun;Lu Cheng;Mao Jiahe;Cao Yuting;Yang Yuyu;Wei Yujiao;Liu Xinhua;Cao Sheng;Song Yang;Peng Junya;Zhou Yunyun;Jiang Qiuyan;Lin Gang;Qin Shuanglin;Qi Min;Hou Min;Liu Xiang;Zhou Honggang;Yang Guang;Yang Cheng |
| 13 | Synthesis and Discovery Novel Anti-Cancer Stem Cells Compounds Derived from the Natural Triterpenoic Acids | 期刊论文 | Liu Xinhua;Li Benlong;Zhang Zhen;Wei Yujiao;Xu Zhongxin;Qin Shuanglin;Liu Ning;Zhao Rui;Peng Junya;Yang Guang;Qi Min;Liu Tongtong;Xie Maodun;Liu Shuangwei;Gao Xian;Lu Cheng;Zhu Lijun;Long Xinyu;Kang Hong;Sun Tao;Zhou Honggang;Wei Mingming;Yang Guang;Yang Cheng |
| 14 | 天然产物Symplostatin4衍生物及其在抗癌症干细胞药物中的应用 | 专利 | 杨诚;杨光;周红刚;孙涛;刘双伟;刘通通;赵芮 |
| 15 | Synthesis of aziridines with multiple chiral substitutions by copper-catalyzed diastereoselective radical aminotrifluoromethylation of alkenes | 期刊论文 | Shuanglin Qin;Linbin Yao;Yunhao Luo;Tongtong Liu;Jiayuan Xu;Yue Sun;Ning Wang;Jun Yan;Bencan Tang;Guang Yang;Cheng Yang |
| 16 | Multi-Gram Scale Synthesis of Chiral 3-Methyl-2,5-trans-tetrahydrofurans | 期刊论文 | Qin Shuanglin;Cao Yuting;Luo Yunhao;Jiang Shende;Clark J. Stephen;Wang Xiaoji;Yang Guang |
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