容积敏感性LRRC8A氯通道介导雌激素调控软骨基质代谢的机制研究
81972085
2019
H0608.骨、关节、软组织退行性病变
王大平
面上项目
主任医师
南方科技大学
55万元
绝经后骨性关节炎;雌激素受体;软骨基质代谢;雌激素;LRRC8A氯通道
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 一种用于延缓软骨细胞去分化的培养液及其制备方法 | 专利 | 邓志钦;李文翠;朱伟民;王大平;赵喆;刘建全;陈小强;段莉;李永胜 |
| 2 | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42 | 期刊论文 | Tao Ma;Lei Wang;Anping Chai;Chao Liu;Wenqiang Cui;Shuguang Yuan;Shannon Wing Ngor Au;Liang Sun;Xiaokang Zhang;Zhenzhen Zhang;Jianping Lu;Yuanzhu Gao;Peiyi Wang;Zhifang Li;Yujie Liang;Horst Vogel;Yu Tian Wang;Daping Wang;Kaige Yan;Huawei Zhang |
| 3 | Molecular basis and therapeutic potential of myostatin on bone formation and metabolism in orthopedic disease | 期刊论文 | Cui Y;Yi Q;Sun W;Huang D;Zhang H;Duan L;Shang H;Wang D;Xiong J. |
| 4 | Inhibitor screening for volume-sensitive LRRC8A chloride channel | 期刊论文 | Chao Liu;Wenqiang Cui;Kongfu Zhu;Shuguang Yuan;Liang Sun;Yujie Liang;Jianping Lu;Da Li;Zhiqin Deng;Li Duan;Weiming Zhang;Xiaohai Yu;Daping Wang;Huawei Zhang |
| 5 | 一种搅拌式干细胞培养生物反应器 | 专利 | 邓志钦;李文翠;王大平;刘建全;林梓聪;王光辉;赵喆;李永胜;陈小强;罗婉婷 |
| 6 | High expression of MAPK-14 promoting the death of chondrocytes is an important signal of osteoarthritis process | 期刊论文 | Deng Zhiqin;Hu Xiaotian;Alahdal Murad;Liu Jianquan;Zhao Zhe;Chen Xiaoqiang;Xie Junxiong;Duan Li;Wang Daping;Li Wencui |
| 7 | The Homeostasis of Cartilage Matrix Remodeling and the Regulation of Volume-Sensitive Ion Channel | 期刊论文 | Zhiqin Deng;Xiaoqiang Chen;Zicong Lin;Murad Alahdal;Daping Wang;Jianquan Liu;Wencui Li |
| 8 | Screening and verification of hub genes involved in osteoarthritis using bioinformatics | 期刊论文 | Junxiong Xie;Zhiqin Deng;Murad Alahdal;Jianquan Liu;Zhe Zhao;Xiaoqiang Chen;Guanghui Wang;Xiaotian Hu;Li Duan;Daping Wang |
| 9 | Applications and prospects of cryo-EM in drug discovery | 期刊论文 | Kong-Fu Zhu;Chuang Yuan;Yong-Ming Du;Kai-Lei Sun;Xiao-Kang Zhang;Horst Vogel;Xu-Dong Jia;Yuan-Zhu Gao;Qin-Fen Zhang;Da-Ping Wang;Hua-Wei Zhang |
| 10 | Crosstalk between immune cells and bone cells or chondrocytes | 期刊论文 | Zhiqin Deng;Qian Zhang;Zhe Zhao;Yongshen Li;Xiaoqiang Chen;Zicong Lin;Zhenhan Deng;Jianquan Liu;Li Duan;Daping Wang;Wencui Li |
| 11 | Cryo-EM structure of human heptameric pannexin 2 channel | 期刊论文 | Hang Zhang;Shiyu Wang;Zhenzhen Zhang;Mengzhuo Hou;Chunyu Du;Zhenye Zhao;Horst Vogel;Zhifang Li;Kaige Yan;Xiaokang Zhang;Jianping Lu;Yujie Liang;Shuguang Yuan;Daping Wang;Huawei Zhang |
| 12 | Chondrocyte-Targeted MicroRNA Delivery by Engineered Exosomes toward a Cell-Free Osteoarthritis Therapy | 期刊论文 | Yujie Liang;Xiao Xu;Xingfu Li;Jianyi Xiong;Biquan Li;Li Duan;Daping Wang;Jiang Xia |
| 13 | 一种细胞培养皿架 | 专利 | 邓志钦;李文翠;王大平;刘建全;张骞;程翔宇;李永胜;段莉;李嘉贝;罗婉婷 |
| 14 | Chloride Channel and Inflammation-Mediated Pathogenesis of Osteoarthritis | 期刊论文 | Zicong Lin;Zhiqin Deng;Jianquan Liu;Zhongshi Lin;Siyu Chen;Zhenhan Deng;Wencui Li |
| 15 | 复合水凝胶支架及其制备方法和应用 | 专利 | 王大平;赵月;张华威 |
| 16 | The Mechanism of Bone Remodeling After Bone Aging | 期刊论文 | Huankun Fang;Zhiqin Deng;Jianquan Liu;Siyu Chen;Zhenhan Deng;Wencui Li |
| 17 | Interleukin 1 beta-induced chloride currents are important in osteoarthritis onset: an in vitro study | 期刊论文 | Zhiqin Deng;Zicong Lin;Qing Zhong;Minqiang Lu;Huankun Fang;Jianquan Liu;Li Duan;Lixin Chen;Liwei Wang;Daping Wang;Wencui Li |
| 18 | 一种动物实验样品采样装置 | 专利 | 邓志钦;李文翠;王大平;刘建全;赵喆;段莉;王光辉;李永胜;陈小强;罗婉婷 |
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