具有癌症早期精确诊断及治疗功能的纳米金系统研究

51773096
2017
E0310.其他有机高分子功能材料
袁直
面上项目
教授
南开大学
58万元
pH响应;纳米金;癌症;自组装;CT造影剂
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 一种自靶向抗癌纳米粒子及其制备方法 专利 袁直;张亚慧
2 Construction of an AuHQ nano-sensitizer for enhanced radiotherapy efficacy through remolding tumor vasculature 期刊论文 Xiaohui Wang;Xiaoyan Niu;Xiaolei Zhang;Zhenjie Zhang;Xuefeng Gao;Wei Wang;Zhi Yuan
3 pH响应多功能封堵剂介孔硅纳米药物靶向递送系统的构建 会议论文 袁直;张亚杰;王蔚
4 A glutathione responsive nitric oxide release system based on charge-reversal chitosan nanoparticles for enhancing synergistic effect against multidrug resistance tumor 期刊论文 Xiaoyan Niu;Jing Cao;Yapei Zhang;Xuefeng Gao;Mingbo Cheng;Yang Liu;Wei Wang;Zhi Yuan
5 Chitosan sulfate inhibits angiogenesis via blocking the VEGF/VEGFR2 pathway and suppresses tumor growth in vivo 期刊论文 Yingying Li;Wei Wang;Yapei Zhang;Xinyu Wang;Xuefeng Gao;Zhi Yuan;Yu Li
6 NIR Light-Driven Bi2Se3-Based Nanoreactor with “Three in One” Hemin-Assisted Cascade Catalysis for Synergetic Cancer Therapy 期刊论文 Xiaoyan Niu;Yang Liu;Xiaomin Li;Wei Wang;Zhi Yuan
7 A pH-responsive Pt-based nanoradiosensitizer for enhanced radiotherapy via oxidative stress amplification 期刊论文 Licheng Yu;Xiaolei Zhang;Xiaomin Li;Zhenjie Zhang;Xiaoyan Niu;Xiaohui Wang;Wei Wang;Zhi Yuan
8 One-pot synthesis of acid-induced in situ aggregating theranostic gold nanoparticles with enhanced retention in tumor cells 期刊论文 Mingbo Cheng;Yahui Zhang;Xiaolei Zhang;Wei Wang;Zhi Yuan
9 A facile composite nanoparticle promoted by photoelectron transfer and consumption for tumor combination therapy 期刊论文 Yahui Zhang;Weizhou Sha;Yang Liu;Wei Wang;Zhi Yuan
10 pH-Sensitive Assembly/Disassembly Gold Nanoparticles with the Potential of Tumor Diagnosis and Treatment 期刊论文 Jinlong Ma;Xiaomin Li;Zhenpeng Hu;Xinyu Wang;Yapei Zhang;Wei Wang;Qiang wu;Zhi Yuan
11 Zwitterionic chitooligosaccharide-modified ink-blue titanium dioxide nanoparticles with inherent immune activation for enhanced photothermal therapy. 期刊论文 Yahui Zhang;Weizhou Sha;Xiaolei Zhang;Mingbo Cheng;Qiang Wu;Wei Wang;Zhi Yuan
12 Single NIR Laser-activated Multifunctional Nanoparticles for Cascaded Photothermal and Oxygen-independent Photodynamic Therapy 期刊论文 Xiaomin Li;Yang Liu;Fei Fu;Mingbo Cheng;Yutong Liu;Licheng Yu;Wei Wang;Yeda Wan;Zhi Yuan
13 壳聚糖硫酸酯对血管新生及肿瘤生长的抑制效果研究 会议论文 李营营;张雅佩;李禹;屈晓津;袁直;王蔚
14 Near-infrared-light induced nanoparticles with enhanced tumor tissue penetration and intelligent drug release 期刊论文 Yapei Zhang;Yang Liu;Xuefeng Gao;Xiaomin Li;Xiaoyan Niu;Zhi Yuan;Wei Wang
15 一种用于肝癌早期诊断的纳米金CT造影剂及其制备方法 专利 袁直;王蔚;呼振鹏;田志清;马金龙
16 Multivalent nanoparticles for personalized theranostics based on tumor receptor distribution behavior 期刊论文 Yahui Zhang;Mingbo Cheng;Jing Cao;Yajie Zhang;Zhi Yuan;Qiang Wu;Wei Wang
17 Convenient preparation of charge-adaptive chitosan nanomedicines for extended blood circulation and accelerated endosomal escape 期刊论文 Yapei Zhang;Yingying Li;Jinlong Ma;Xinyu Wang;Zhi Yuan;Wei Wang
18 Fluorescence-enhanced covalent organic framework nanosystem for tumor imaging and photothermal therapy 期刊论文 Yang Liu;Yapei Zhang;Xiaomin Li;Xuefeng Gao;Xiaoyan Niu;Wei Wang;Qiang Wu;Zhi Yuan
19 一种肝靶向载铂纳米前药的结构及其制备方法 专利 袁直;王蔚;王新宇
20 Dual pH-responsive "charge-reversal like" gold nanoparticles to enhance tumor retention for chemo-radiotherapy 期刊论文 Xiaolei Zhang;Chuangnian Zhang;Mingbo Cheng;Yahui Zhang;Wei Wang;Zhi Yuan
21 Acid-responsive aggregated SERS nanoparticles for improved tumor diagnose 期刊论文 Xiaoyan Niu;Licheng Yu;Xiaohui Wang;Zhenjie Zhang;Xiaomin Li;Xiaoyue Feng;Wei Wang;Zhi Yuan
22 具有肿瘤血管重塑功能的纳米放疗增敏剂的构建 会议论文 王蔚;王晓辉;冯潇月
23 Reversible Shielding between Dual Ligands for Enhanced Tumor Accumulation of ZnPc-Loaded Micelles 期刊论文 Jing Cao;Xuefeng Gao;Mingbo Cheng;Xiaoyan Niu;Xiaomin Li;Yapei Zhang;Yang Liu;Wei Wang;Zhi Yuan
24 一种单光激活纳米粒子以及制备方法和应用 专利 袁直;李晓敏
25 Construction of a pH/TGase “Dual Key”-Responsive Gold Nanoradiosensitizer with Liver Tumor-Targeting Ability 期刊论文 Zhenjie Zhang;Xiaoyan Niu;Xiaoyue Feng;Xiaohui Wang;Licheng Yu;Wei Wang;Zhi Yuan
26 In situ self-assembled biosupramolecular porphyrin nanofibers for enhancing photodynamic therapy in tumors 期刊论文 Yang Liu;Xiaomin Li;Xiaoyan Niu;Licheng Yu;Weizhou Sha;Wei Wang;Zhi Yuan
27 The effects of ligand valency and density on the targeting ability of multivalent nanoparticles based on negatively charged chitosan nanoparticles 期刊论文 Jing Cao;Yahui Zhang;Yukun Wu;Jing Wu;Wei Wang;Qiang Wu;Zhi Yuan
28 具有血液长循环性能的壳聚糖纳米粒子的制备 会议论文 张雅佩;袁直
29 The systematic evaluation of size-dependent toxicity and multi-time biodistribution of gold nanoparticles 期刊论文 Xiaomin Li;Zhenpeng Hu;Jinlong Ma;Xinyu Wang;Yapei Zhang;Wei Wang;Zhi yuan
30 Chitosan Sulfate Inhibits Angiogenesis to Suppress Tumor Growth in Vivo 会议论文 Li Yingying;Qu Xiaojin;Li Yu;Wang Wei;Yuan Zhi
31 TGase-induced intracellular aggregation of Fe3O4 nanoparticles for increased retention and enhanced T2 MRI 期刊论文 Xuefeng Gao;Yang Liu;Yingying Li;Xiaoyan Niu;Jing Cao;Xiaomin Li;Yapei Zhang;Dongzhi Tan;Wei Wang;Zhi Yuan
32 Tumor acid microenvironment-activated self-targeting & splitting gold nanoassembly for tumor chemo-radiotherapy 期刊论文 Xiaomin Li;Licheng Yu;Chuangnian Zhang;Xiaoyan Niu;Mengjie Sun;Zichao Yan;Wei Wang;Zhi Yuan
33 An oxidation responsive nano-radiosensitizer increases radiotherapy efficacy by remolding tumor vasculature 期刊论文 Xiaohui Wang;Xiaoyan Niu;Weizhou Sha;Xiaoyue Feng;Licheng Yu;Zhenjie Zhang;Wei Wang;Zhi Yuan
34 一种具有双配体可逆互屏蔽的靶向纳米胶束的结构及载药系统 专利 袁直;曹兢;王蔚
35 一种用于提高肿瘤组织渗透性的纳米粒子及其制备方法和应用 专利 袁直;张雅佩
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