【21172124】羧酸酰胺类杀菌剂的分子设计、多组分合成与杀菌活性研究国家自然基金项目

羧酸酰胺类杀菌剂的分子设计、多组分合成与杀菌活性研究

项目批准号： 21172124

批准年份： 2011

学科分类： B0706.药物化学生物学

项目负责人：赵卫光

资助类别：面上项目

负责人职称：研究员

依托单位：南开大学

资助金额： 60万元

关键词：纤维素合成酶;羧酸酰胺;药效团;杀菌剂;同源模建

起止时间： 2012-01-01到2015-12-31

中英文摘要
结题摘要
结题报告
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序号	标题	类型	作者
1	Novel exocyclic enamides: synthesis and evaluation of the fungicidal activities of 5-methylene-2-(trifluoromethyl)morpholin-3-one derivatives	期刊论文	Zhu, Cong\|Yang, Hui-Hui\|Li, Jian-Qiang\|Zhao, Wei-Guang\|
2	Drug Repurposing Based on Drug–Drug Interaction	期刊论文	Bin Zhou\|Rong Wang\|Ping Wu\|De-Xin De\|
3	具有杀菌活性的缬氨酸酰胺氨基甲酸酯类化合物的构效关系和非缬氨酸酰胺氨基甲酸酯类化合物的发现	会议论文
4	新型N-二苯甲基缬氨酸氨基甲酸酯类羧酸酰胺杀菌剂的设计合成和杀菌活性	会议论文
5	Ultrasound-promoted sterically congested Passerini reactions under solvent-free conditions	期刊论文	X. J. Du\|Z. P. Wang\|Z. M. Li\|W. G. Zhao\|
6	新型缬氨酸酰胺类杀菌剂的设计、合成与杀菌活性	会议论文
7	2-乙氧羰基苯乙酰胺类化合物的合成与杀菌活性	会议论文
8	Design, synthesis, and fungicidal activities of imino diacid analogs of valine amide fungicides	期刊论文	Hui-Hui Yang\|Lei Tian\|Jian-Qiang Li\|Wei-Guang Zhao\|
9	Microwave-assisted synthesis of some novel 1,2,3-triazoles by click chemistry, and their biological activity	期刊论文	Yu, Shu-Jing\|Zhang, Xiao\|Liu, Xing-Hai\|Zhao, Wei-Guang\|
10	Larvicidal Activity and Click Synthesis of 2-Alkoxyl-2-(1,2,3-Triazole-1-yl)Acetamide Library	期刊论文	Zhang, Xiao\|Cui, Can\|Li, Zheng-Ming\|Zhao, Wei-Guang\|
11	Improving catalytic efficiency of endo-beta-1, 4-xylanase from Geobacillus stearothermophilus by directed evolution and H179 saturation mutagenesis	期刊论文	Zhan, Tao\|Huang, Zongqing\|Wu, Guojie\|Liu, Ziduo\|
12	新型缬氨酸酰胺类杀菌剂的设计、合成与杀菌活性	奖励
13	Synthesis, bioactivity and DFT structure-activity relationship study of novel 1,2,3-thiadiazole derivatives	期刊论文	Liu, Xing-Hai\|Zhao, Wei-Guang\|Wang, Bao-Lei\|Li, Zheng-Ming\|
14	Synthesis and Antifungal Activity of Novel 1,2,4-Triazole Derivatives Containing 1,2,3-Thiadiazole Moiety	期刊论文	Weng, Jian-Quan\|Liu, Xing-Hai\|Zhao, Wei-Guang\|Li, Bao-Ju\|
15	Design, synthesis and antifungal activity of carboxylic acid amide fungicides: part 2: substituted 1-phenyl-2-phenoxyethylamino valinamide carbamates	期刊论文	Gao, Yang\|Du, Xiu-Jiang\|Li, Yong-Hong\|Zhao, Wei-Guang\|
16	Synthesis and Bioactivity of N-(2-Alkoxy-2-substituted phenyl-ethyl) phenyl Amide	期刊论文	Li Yong-Qiang\|Wang Li-Zhong\|Li Zheng-Ming\|Zhao Wei-Guang\|
17	Interaction of characteristic structural elements of persimmon tannin with Chinese cobra PLA(2)	期刊论文	Zhong, Li\|Zhou, Bin\|Chen, Jin-yu\|Li, Chun-mei\|
18	N-[(2-烷氧基)-取代苯乙基]-苯乙酰胺类化合物的合成及生物活性	期刊论文	李永强\|王力钟\|李正名\|赵卫光\|
19	小麦锈病最佳筛选条件研究	会议论文
20	Improving catalytic efficiency of endo-beta-1, 4-xylanase from Geobacillus stearothermophilus by directed evolution and H179 saturation mutagenesis	期刊论文	Zhan, Tao\|Huang, Zongqing\|Wu, Guojie\|Liu, Ziduo\|
21	Synthesis and fungicidal activity of new fluorine-containing mandelic acid amide compounds	期刊论文	Zhang, Xiao\|Li, Zheng-Ming\|Zhao, Wei-Guang\|Li, Bao-Ju\|
22	小麦锈病活体筛选方法的规范化	期刊论文	张晓\|王力钟\|赵卫光\|李宝聚\|
23	Synthesis and characteristics of (Hydrogenated) ferulic acid derivatives as potential antiviral agents with insecticidal activity	期刊论文	Wang, Li-Zhong\|Yu, Shu-Jing\|Li, Zheng-Ming\|Zhao, Wei-Guang\|
24	Synthesis, crystal structure and larvicidal activity of novel diamide derivatives against Culex pipiens	期刊论文	Yu, Shu-Jing\|Liu, Xing-Hai\|Li, Zheng-Ming\|Zhao, Wei-Guang\|
25	Design, synthesis, and fungicidal activity of novel carboxylic acid amides represented by N-benzhydryl valinamode carbamates	期刊论文	Kou, Jun-Jie\|Wang, Zhi-Peng\|Li, Zheng-Ming\|Zhao, Wei-Guang\|
26	基于活性碎片的药物设计方法：一种发现新的羧酸酰胺类杀菌剂的新方法	会议论文
27	Synthesis and Antiviral Activity of Hydrogenated Ferulic Acid Derivatives	期刊论文	Yu, Shu-Jing\|Liu, Xing-Hai\|Li, Zheng-Ming\|Zhao, Wei-Guang\|
28	新型缬氨酰胺氨基乙酸类化合物的合成及活性研究	会议论文
29	黄瓜棒孢叶斑病的防治及抗药性研究进展	期刊论文	田芳\|赵卫光\|边强\|李宝聚\|
30	N-(3,5-二甲氧基-4-烷氧基苯乙基)扁桃酰胺类杀菌剂的设计合成及杀菌活性	期刊论文	王红学\|于淑晶\|张晓\|赵卫光\|
31	Design, synthesis, and fungicidal activity of novel carboxylic acid amides represented by N-benzhydryl valinamode carbamates	期刊论文	Kou, Jun-Jie\|Wang, Zhi-Peng\|Li, Zheng-Ming\|Zhao, Wei-Guang\|
32	Solvent-free Bronsted acid-catalyzed Michael addition of nitrogen- and carbon-containing nucleophiles by ultrasound activation	期刊论文	Hou, Yan-Ling\|Zhang, Cheng\|Li, Zheng-Ming\|Zhao, Wei-Guang\|
33	Design, synthesis, and fungicidal evaluation of a series of novel 5-methyl-1H-1,2,3-trizole-4-carboxyl amide and ester analogues	期刊论文	Yu, Shu-Jing\|Bian, Qiang\|Li, Zheng-Ming\|Zhao, Wei-Guang\|
34	Novel Ultrasound-Promoted Parallel Synthesis of Trifluoroatrolactamide Library via a One-Pot Passerini/Hydrolysis Reaction Sequence and Their Fungicidal Activities	期刊论文	Cui, Can\|Du, Xiu-Jiang\|Li, Zheng-Ming\|Zhao, Wei-Guang\|
35	Design, Synthesis, and Fungicidal Activities of Novel 5-Methyl-1H-1,2,3-trizole-4-carboxyl Amide Analogues	期刊论文	Zhen-Jun Wang\|Hui-Hui Yang\|Lei Tian\|赵卫光\|
36	Interaction of characteristic structural elements of persimmon tannin with Chinese cobra PLA(2)	期刊论文	Zhong, Li\|Zhou, Bin\|Chen, Jin-yu\|Li, Chun-mei\|
37	Synthesis and Antifungal Activity of 1,2,4-triazole Derivatives Containing Cyclopropane Moiety	期刊论文	Weng, Jian-Quan\|Liu, Xing-Hai\|Li, Bao-Ju\|Zhao, Wei-Guang\|
38	Exploring the Biologically Relevant Chemical Space for Drug Discovery	期刊论文	Wang, Rong\|Peng, Shi-Yu\|Zhang, Hong-Yu\|Kong, De-Xin\|
39	高通量筛选技术在农用杀菌剂创制研究中的应用	期刊论文	王满意\|张晓\|李宝聚\|赵卫光\|

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