新型组蛋白去乙酰化酶抑制剂的设计和合成

21072105
2010
B0706.药物化学生物学
沈杰
面上项目
副教授
南开大学
36万元
点击化学;组蛋白去乙酰化酶;次膦酸酰胺;抑制剂;同源模建
2011-01-01到2013-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Discovery and structural insight of a highly selective protein kinase inhibitor hit through click chemistry 期刊论文 Wang, Peng George|Wang, Huihui|Liu, Pi|Fu, Chenzeng|Li, Zhonghua|Cao, Xuefeng|Li, Yunping|Fang, Qinghong|Xu, Feng|
2 Antitumor effects of a novel histone deacetylase inhibitor NK-HDAC-1 on breast cancer 期刊论文 Li, Zhong-Hua|Zhang, Xiao-Bing|Han, Xi-Qian|Feng, Cong-Ran|Wang, Feng-Shan|Wang, Peng George|Shen, Jie|Shi, Yi-Kang|
3 The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances taxol-induced cell death in breast cancer 期刊论文 Wang, Peng|Li, Zhong-hua|Han, Xi-qian|Yi, Ji-hu|Wang, Zhen-hua|Hou, Jing-li|Feng, Cong-ran|Fang, Qing-hong|Wang, Hui-hui|
4 Structure-based optimization of click-based histone deacetylase inhibitors 期刊论文 Wang, Peng|Feng, Congran|Li, Zhonghua|Fang, Qinghong|Wang, Huihui|Gu, Guoxian|Shi, Yikang|Liu, Pi|Xu, Feng|
5 Therapeutic Effects of NK-HDAC-1, a Novel Histone Deacetylase Inhibitor, on Collagen-Induced Arthritis Through the Induction of Apoptosis of Fibroblast-Like Synoviocytes 期刊论文 Li, Zhanguo|Liu, Xu|Sun, Xiaolin|Wang, Zhenhua|Guo, Weikang|Hu, Fanlei|Yao, Haihong|Cao, Xuefeng|Jin, Jin|
6 Discovery and Extensive in Vitro Evaluations of NK-HDAC-1: A Chiral Histone Deacetylase Inhibitor as a Promising Lead 期刊论文 Wang, Peng George|Li, Zhonghua|Fang, Qinghong|Feng, Congran|Zhang, Hanwen|Guo, Weikang|Wang, Huihui|Gu, Guoxian|Tian, Yinping|
7 A Safe and Facile Route to Imidazole-1-sulfonyl Azide as a Diazotransfer Reagent 期刊论文 沈杰|
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