农药靶标抗性的分子机制研究及农药分子设计合成

20932005
2009
B0706.药物化学生物学
席真
重点项目
教授
南开大学
180万元
农药;分子设计;农药抗性;农药靶标;构效关系
2010-01-01到2013-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Experimental and computational correlation and prediction on herbicide resistance for acetohydroxyacid synthase mutants to Bispyribac 期刊论文 He YinWu|Niu CongWei|Li Hank|Wen Xin|Xi Zhen|
2 Design, syntheses and 3D-QSAR studies of novel N-phenyl pyrrolidin-2-ones and N-phenyl-1H-pyrrol-2-ones as protoporphyrinogen oxidase inhibitors 期刊论文 Zhang, Li|Tan, Yin|Wang, Neng-Xue|Wu, Qiong-You|Xi, Zhen|Yang, Guang-Fu|
3 Modification of the siRNA Passenger Strand by 5-Nitroindole Dramatically Reduces its Off-Target Effects 期刊论文 Zhang, Junbin|Zheng, Jie|Lu, Chang|Du, Quan|Liang, Zicai|Xi, Zhen|
4 Facile Synthesis of 3-Substituted Isoquinolines Derivatives via Microwave-assisted Tandem Three-component Coupling Cyclization 期刊论文 林龙|吴琼友|黄绍维|杨光富|
5 Rieske iron-sulfur protein of the cytochrome bc(1) complex: a potential target for fungicide discovery. 期刊论文 Yang, Wen-Chao|Li, Hui|Wang, Fu|Zhu, Xiao-Lei|Yang, Guang-Fu|
6 Synthesis and antifungal activity of 3-(1,3,4-oxadiazol-5-yl)-indoles and 3-(1,3,4-oxadiazol-5-yl)methyl-indoles. 期刊论文 Zhang, Ming-Zhi|Mulholland, Nick|Beattie, David|Irwin, Dianne|Gu, Yu-Cheng|Chen, Qiong|Yang, Guang-Fu|Clough, John|
7 Novel synthetic methods for N-cyano-1H-imidazole-4-carboxamides and their fungicidal activity 期刊论文 Yang, Wen-Chao|Li, Jing|Li, Jun|Chen, Qiong|Yang, Guang-Fu|
8 Synthesis and Bioactivity of N-(5 ';-Bromo-4 ';-substituted pyrimidin-2 ';-yl)phenyl Sulfonylurea 期刊论文 Ban Shurong|Niu Congwei|Chen Wenbin|Li Qingshan|Xi Zhen|
9 Insight into the Structural Requirements of Protoporphyrinogen Oxidase Inhibitors: Molecular Docking and CoMFA of Diphenyl Ether, Isoxazole Phenyl, and Pyrazole Phenyl Ether 期刊论文 Shenggang Yang|Gefei Hao|Franck E.Dayan|Patrick J.Tranel|Guangfu Yang|
10 Single modification at position 14 of siRNA strand abolishes its gene-silencing activity by decreasing both RISC loading and target degradation. 期刊论文 Zheng, Jie|Zhang, Lei|Zhang, Junbin|Wang, Xiaoxia|Ye, Keqiong|Xi, Zhen|Du, Quan|Liang, Zicai|
11 Biomacromolecular 3D-QSAR to Decipher Molecular Herbicide Resistance in Acetohydroxyacid Synthases 期刊论文 He, Yinwu|Niu, Congwei|Wen, Xin|Xi, Zhen|
12 Computational discovery of picomolar Q(o) site inhibitors of cytochrome bc1 complex. 期刊论文 Hao, Ge-Fei|Wang, Fu|Li, Hui|Zhu, Xiao-Lei|Yang, Wen-Chao|Huang, Li-Shar|Wu, Jia-Wei|Berry, Edward A|Yang, Guang-Fu|
13 Synthesis and antitumour activity of inositol phosphonate analogues 期刊论文 Song, Fanbo|Zhang, Jing|Cui, Quanbin|Wang, Ting|Chen, Wenbin|Li, Luyuan|Xi, Zhen|
14 Quantitative structure-activity relationships of 1,3,4-thiadiazol-2(3H)-ones and 1,3,4-oxadiazol-2(3H)-ones as human protoporphyrinogen oxidase inhibitors 期刊论文 Zuo, Yang|Yang, Sheng-Gang|Jiang, Li-Li|Hao, Ge-Fei|Wang, Zhi-Fang|Wu, Qiong-You|Xi, Zhen|Yang, Guang-Fu|
15 Synthesis and antifungal activity of novel sclerotiorin analogues. 期刊论文 Lin, Long|Mulholland, Nick|Wu, Qiong-You|Beattie, David|Huang, Shao-Wei|Irwin, Dianne|Clough, John|Gu, Yu-Cheng|Yang, Guang-Fu|
16 Identification and functional characterization of BTas transactivator as a DNA-binding protein 期刊论文 Tan, Juan|Hao, Peng|Jia, Rui|Yang, Wei|Liu, Ruichang|Wang, Jinzhong|Xi, Zhen|Geng, Yunqi|Qiao, Wentao|
17 Antofine Analogues Can Inhibit Tobacco Mosaic Virus Assembly through Small-Molecule-RNA Interactions 期刊论文 Gao, Shuang|Zhang, Ruoyu|Yu, Zhihong|Xi, Zhen|
18 Computational determination of fundamental pathway and activation barriers for acetohydroxyacid synthase-catalyzed condensation reactions of alpha-keto acids. 期刊论文 Xiong, Ying|Liu, Junjun|Yang, Guang-Fu|Zhan, Chang-Guo|
19 Efficient synthesis of functionalized 6-arylsalicylates via microwave-promoted Suzuki cross-coupling reaction 期刊论文 Yu-Chao Liu|Zhi-You Huang|Qiong Chen|Guang-Fu Yang|
20 Design and Syntheses of Novel N-(Benzothiazol-5-yl)-4,5,6,7-tetrahydro-1H-isoindole-1,3(2H)-dione and N-(Benzothiazol-5-yl)isoindoline-1,3-dione as Potent Protoporphyrinogen Oxidase Inhibitors 期刊论文 Jiang, Li-Li|Zuo, Yang|Wang, Zhi-Fang|Tan, Yin|Wu, Qiong-You|Xi, Zhen|Yang, Guang-Fu|
21 Efficient synthesis and antiproliferative activity of novel thioether-substituted flavonoids. 期刊论文 Huang, Wei|Chen, Qiong|Yang, Wen-Chao|Yang, Guang-Fu|
22 Comprehensive analysis of sequence-specific stability of siRNA 期刊论文 Liang, Zicai|Huang, Yuanyu|Li, Jun|Yi, Fan|Zheng, Jie|Huang, Huang|Wei, Na|Shan, Yongqiang|An, Mingrui|
23 A BH3 masked H-phosphonate for coupling in oligonucleotide synthesis 期刊论文 Huang, Jinyu|Lu, Wei|Xi, Zhen|
24 Molecular Drug Resistance Prediction for Acetohydroxyacid Synthase Mutants Against Chlorsulfuron Using MB-QSAR 期刊论文 He, Yinwu|Niu, Congwei|Wen, Xin|Xi, Zhen|
25 Synthesis and in vitro Fungicidal Activity of a Series of Novel N-(Heterocycly)phthalimides 期刊论文 Ban Shurong|Chen Wenbin|Xi Zhen|
26 InBr3-catalyzed cyclization of glycosides with arylamines 期刊论文 Pingyuan Wang|Meining Wang|Xuefeng Zhang|Guangfu Yang|Ao Zhang|
27 Insight into herbicide resistance of W574L mutant Arabidopsis thaliana acetohydroxyacid synthase: molecular dynamics simulations and binding free energy calculations 期刊论文 Yu ZhiHong|Wen Xin|Xi Zhen|
28 Highly Potent and Stable Capped siRNAs with Picomolar Activity for RNA Interference 期刊论文 Wei, Lv|Cao, Liqiang|Xi, Zhen|
29 Pest control: risks of biochemical pesticides. 期刊论文 Hao, Gefei|Yang, Guangfu|
30 A comparative study of drug resistance mechanism associated with active site and non-active site mutations: I388N and D425G mutants of acetyl-coenzyme-A carboxylase. 期刊论文 Zhu, Xiao-Lei|Yang, Guang-Fu|
31 Computational gibberellin-binding channel discovery unraveling the unexpected perception mechanism of hormone signal by gibberellin receptor. 期刊论文 Hao, Ge-Fei|Yang, Sheng-Gang|Yang, Guang-Fu|Zhan, Chang-Guo|
32 Protoporphyrinogen oxidase inhibitor: an ideal target for herbicide discovery. 期刊论文 Hao, Ge-Fei|Zuo, Yang|Yang, Sheng-Gang|Yang, Guang-Fu|
33 Structural basis of femtomolar inhibitors for acetylcholinesterase subtype selectivity: insights from computational simulations. 期刊论文 Zhu, Xiao-Lei|Yu, Ning-Xi|Hao, Ge-Fei|Yang, Wen-Chao|Yang, Guang-Fu|
34 Chemical synthesis of bioactive siRNA in solution phase by using 2-(azidomethyl)benzoyl as 3 ';-hydroxyl group protecting group 期刊论文 Huang, Jinyu|Xi, Zhen|
35 The role of Phe82 and Phe351 in auxin-induced substrate perception by TIR1 ubiquitin ligase: a novel insight from molecular dynamics simulations. 期刊论文 Hao, Ge-Fei|Yang, Guang-Fu|
36 Efficient synthesis of bulky 4-substituted-isatins via microwave-promoted Suzuki cross-coupling reaction 期刊论文 Yu-Chao Liu|Chen-Jin Ye|Qiong Chen|Guang-Fu Yang|
37 Quantitative Structural Insight into Human Variegate Porphyria Disease 期刊论文 Wang, Baifan|Wen, Xin|Qin, Xiaohong|Wang, Zhifang|Tan, Ying|Shen, Yuequan|Xi, Zhen|
38 Non-peptide-based fluorogenic small-molecule probe for elastase. 期刊论文 Sun, Qi|Li, Jun|Liu, Wan-Nian|Dong, Qing-Jian|Yang, Wen-Chao|Yang, Guang-Fu|
39 Comparative Kinetics of Qi Site Inhibitors of Cytochrome bc1 Complex: Picomolar Antimycin and Micromolar Cyazofamid. 期刊论文 Li, Hui|Zhu, Xiao-Lei|Yang, Wen-Chao|Yang, Guang-Fu|
40 Novel coumarin-based sensitive and selective fluorescent probes for biothiols in aqueous solution and in living cells 期刊论文 Li, Jun|Zhang, Chun-Fang|Ming, Ze-Zhong|Yang, Wen-Chao|Yang, Guang-Fu|
41 Fast thiol-maleamic methyl ester addition for facile covalent cross-linking of oligonucleotides 期刊论文 Cao, Liqiang|Xi, Zhen|
42 Sparsomycin–Linezolid Conjugates Can Promote Ribosomal Translocation 期刊论文 Shibo Li|Xiaofeng Cheng|Yonghang Zhou|Zhen Xi|
43 The Minimum Activation Peptide from ilvH Can Activate the Catalytic Subunit of AHAS from Different Species 期刊论文 Zhao, Yuefang|Niu, Congwei|Wen, Xin|Xi, Zhen|
44 Design, Synthesis, and Bioevaluation of Novel Strobilurin Derivatives 期刊论文 朱晓磊|王福|李慧|杨文超|陈琼|杨光富|
45 Probing the Function of Nucleotides in the Catalytic Cores of the 8-17 and 10-23 DNAzymes by Abasic Nucleotide and C3 Spacer Substitutions 期刊论文 Wang, Bin|Cao, Liqiang|Chiuman, William|Li, Yingfu|Xi, Zhen|
46 Preliminary X-ray crystallographic studies of the catalytic subunit of Escherichia coli AHAS II with its cofactors 期刊论文 Niu, Xuhui|Liu, Xiang|Zhou, Yanfei|Niu, Congwei|Xi, Zhen|Su, Xiao-Dong|
47 Synthesis and antitumor activity of inositol phosphotriester analogues 期刊论文 Song, Fanbo|Zhang, Jing|Zhao, Yuefang|Chen, Wenbin|Li, Luyuan|Xi, Zhen|
48 Computational and experimental insights into the mechanism of substrate recognition and feedback inhibition of protoporphyrinogen oxidase. 期刊论文 Hao, Ge-Fei|Tan, Ying|Yang, Sheng-Gang|Wang, Zhi-Fang|Zhan, Chang-Guo|Xi, Zhen|Yang, Guang-Fu|
49 Structural insight into human variegate porphyria disease 期刊论文 Qin, Xiaohong|Tan, Ying|Wang, Lele|Wang, Zhifang|Wang, Baifan|Wen, Xin|Yang, Guangfu|Xi, Zhen|Shen, Yuequan|
50 Arginine 26 and Aspartic Acid 69 of the Regulatory Subunit are Key Residues of Subunits Interaction of Acetohydroxyacid Synthase Isozyme III from E. coli 期刊论文 Zhao, Yuefang|Wen, Xin|Niu, Congwei|Xi, Zhen|
51 Structural insight into unique properties of protoporphyrinogen oxidase from Bacillus subtilis 期刊论文 Shen, Yuequan|Sun, Lu|Wen, Xin|Yang, Xue|Tan, Ying|Jin, Hao|Cao, Qiongyao|Zhou, Weihong|Xi, Zhen|
52 Coumarin-based novel fluorescent zinc ion probe in aqueous solution 期刊论文 Jun Li|Chun-Fang Zhang|Ze-Zhong Ming|Ge-Fei Hao|Wen-Chao Yang|Guang-Fu Yang|
53 Microwave-assisted synthesis of benzothiazoleurea derivatives 期刊论文 Chen, Wenbin|Li, Kejian|Wang, Yong|Xi, Zhen|
54 Hydrogen-Deuterium Exchange Reaction of 2-Benzylthio-5-Methyl-1,2,4-Triazolo [1,5-a]Pyrimidine Under Basic Conditions 期刊论文 Li, Fang|Chen, Qiong|Liu, Chen-Chen|Wu, Yue-Hong|Liu, Xiao-Peng|Yang, Guang-Fu|
55 Subnanomolar inhibitor of cytochrome bc1 complex designed by optimizing interaction with conformationally flexible residues. 期刊论文 Zhao, Pei-Liang|Wang, Le|Zhu, Xiao-Lei|Huang, Xiaoqin|Zhan, Chang-Guo|Wu, Jia-Wei|Yang, Guang-Fu|
56 Syntheses and herbicidal activity of new triazolopyrimidine-2-sulfonamides as acetohydroxyacid synthase inhibitor 期刊论文 Chen, Chao-Nan|Chen, Qiong|Liu, Yu-Chao|Zhu, Xiao-Lei|Niu, Cong-Wei|Xi, Zhen|Yang, Guang-Fu|
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