原发性骨髓纤维化分子发病机制和抗纤维化新药的研究
81530008
2015
H0808.骨髓增殖性肿瘤
肖志坚
重点项目
主任医师
中国医学科学院
274万元
克隆演变;抗纤维化药物;脾肿大;原发性骨髓纤维化;小鼠模型
2016-01-01到2020-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
查看更多信息请先登录或注册
查看更多信息请先登录或注册
查看更多信息请先登录或注册
| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis | 期刊论文 | Li Bing;Gale Robert Peter;Xu Zefeng;Qin Tiejun;Song Zhen;Zhang Peihong;Bai Jie;Zhang Lei;Zhang Yue;Liu Jinqin;Huang Gang;Xiao Zhijian |
| 2 | MLF1IP promotes normal erythroid proliferation and is involved in the pathogenesis of polycythemia vera | 期刊论文 | Feng Gege;Zhang Tianjiao;Liu Jinqin;Ma Xiaotang;Li Bing;Yang Lin;Zhang Yue;Xu Zefeng;Qin Tiejun;Zhou Jiaxi;Huang Gang;Shi Lihong;Xiao Zhijian |
| 3 | 靶向测序检测511例骨髓增生异常综合征患者基因突变 | 期刊论文 | 李冰;王静雅;刘晋琴;史仲珣;彭帅玲;黄慧君;秦铁军;徐泽锋;张悦;方力维;张宏丽;胡耐博;潘丽娟;曲士强;肖志坚 |
| 4 | 真性红细胞增多症和原发性血小板增多症后骨髓纤维化患者的预后研究 | 期刊论文 | 陈猛;徐泽锋;徐俊卿;李冰;张培红;秦铁军;张悦;王静雅;张宏丽;方力维;潘丽娟;胡耐博;曲士强;肖志坚 |
| 5 | 伴PNH克隆的骨髓增生异常综合征患者临床和实验室特征分析 | 期刊论文 | 李艳;秦铁军;徐泽锋;张悦;王静雅;李冰;方力维;潘丽娟;胡耐博;张宏丽;曲士强;刘晋琴;王慧君;肖志坚 |
| 6 | 单中心60例高嗜酸粒细胞综合征的临床特征及长期疗效 | 期刊论文 | 曲士强;秦铁军;徐泽锋;张悦;艾小菲;李冰;张宏丽;方力维;潘丽娟;胡耐博;肖志坚 |
| 7 | Molecular and clinical features of myeloid neoplasms with somatic DDX41 mutations | 期刊论文 | Qu Shiqiang;Li Bing;Qin Tiejun;Xu Zefeng;Pan Lijuan;Hu Naibo;Huang Gang;Gale Robert Peter;Xiao Zhijian |
| 8 | HIF1A is a critical downstream mediator for hemophagocytic lymphohistiocytosis | 期刊论文 | Huang Rui;Hayashi Yoshihiro;Yan Xiaomei;Bu Jiachen;Wang Jieyu;Zhang Yue;Zhou Yile;Tang Yuting;Wu Lingyun;Xu Zefeng;Liu Xin;Wang Qianfei;Zhou Jianfeng;Xiao Zhijian;Bridges James P.;Marsh Rebecca A.;Zhang Kejian;Jordan Michael B.;Li Yuhua;Huang Gang |
| 9 | 一项中国对骨髓增殖性肿瘤的影响和治疗目标认识的Landmark调查结果分析 | 期刊论文 | 徐泽锋;肖志坚 |
| 10 | Clinical features and biological implications of different U2AF1 mutation types in myelodysplastic syndromes | 期刊论文 | Li Bing;Liu Jinqin;Jia Yujiao;Wang Jingya;Xu Zefeng;Qin Tiejun;Shi Zhongxun;Song Zhen;Peng Shuailing;Huang Huijun;Fang Liwei;Zhang Hongli;Pan Lijuan;Hu Naibo;Qu Shiqiang;Zhang Yue;Wu Jian;Liu Na;Ru Kun;Huang Gang;Xiao Zhijian |
| 11 | Validation of the WHO 2016 proposals for Myelodysplastic syndromes patients with the presence of ring sideroblasts but without excess blasts | 期刊论文 | Li Yi;Cui Rui;Qin Tiejun;Xu Zefeng;Zhang Yue;Cai Wenyu;Cui Wen;Liu Jinqin;Li Bing;Xiao Zhijian |
| 12 | Multiplex ligation-dependent probe amplification assay identifies additional copy number changes compared with R-band karyotype and provide more accuracy prognostic information in myelodysplastic syndromes | 期刊论文 | Wang Jingya;Ai Xiaofei;Qin Tiejun;Xu Zefeng;Zhang Yue;Liu Jinqin;Li Bing;Fang Liwei;Zhang Hongli;Pan Lijuan;Hu Naibo;Qu Shiqiang;Cai Wenyu;Ru Kun;Jia Yujiao;Huang Gang;Xiao Zhijian |
| 13 | Prognostic mutations in persons with isolated neutropenia myelodysplastic syndrome | 期刊论文 | Shi Zhongxun;Qin Tiejun;Xu Zefeng;Li Bing;Huang Huijun;Zhang Hongli;Fang Liwei;Pan Lijuan;Hu Naibo;Qu Shiqiang;Huang Gang;Gale Robert Peter;Xiao Zhijian |
| 14 | 地西他滨治疗难治性贫血伴有原始细胞过多的疗效和不良反应与治疗疗程数的关系 | 期刊论文 | 雒雪萍;徐泽锋;秦铁军;张悦;张宏丽;方力维;潘丽娟;胡耐博;曲士强;李冰;肖志坚 |
| 15 | 不同血小板水平原发性骨髓纤维化患者的临床特征及预后研究 | 期刊论文 | 徐泽锋;秦铁军;张宏丽;方力维;胡耐博;潘丽娟;曲士强;李冰;严欣;史仲珣;黄慧君;刘丹;蔡亚楠;张瑜堤;张培红;肖志坚 |
| 16 | A systematic classification of megakaryocytic dysplasia and its impact on prognosis for patients with myelodysplastic syndromes | 期刊论文 | Gege Feng;Robert Peter Gale;Wen Cui;Wenyu Cai;Gang Huang;Zefeng Xu;Tiejun Qin;Yue Zhang;Bing Li;Liwei Fang;Hongli Zhang;Lijuan Pan;Naibo Hu;Shiqiang Qu;Jingya Wang;Yajuan Cui;Zhijian Xiao |
| 17 | 骨髓增殖性肿瘤患者巨核细胞病理特征及其与起始基因突变的相关性 | 期刊论文 | 史仲珣;张培红;李冰;方丽华;徐泽锋;秦铁军;刘晋琴;胡耐博;潘丽娟;曲士强;刘丹;肖志坚 |
| 18 | 高嗜酸性粒细胞综合征及慢性嗜酸性粒细胞白血病的靶向测序研究 | 期刊论文 | 曲士强;秦铁军;徐泽锋;张悦;贾玉娇;艾小飞;张宏丽;方力维;胡耐博;潘丽娟;李冰;刘晋琴;汝昆;肖志坚 |
| 19 | Targeted therapies for myeloproliferative neoplasms | 期刊论文 | Li Bing;Rampal Raajit K.;Xiao Zhijian |
| 20 | 骨髓纤维化患者RAS基因突变特征及其预后意义 | 期刊论文 | 吴君颖;李冰;贾玉娇;张培红;徐泽锋;秦铁军;曲士强;潘丽娟;刘晋琴;严欣;张喻堤;陈佳;龚婧晔;肖志坚 |
| 21 | Prognostic impact of red blood cell distribution width in myelodysplastic syndromes | 期刊论文 | Shi Zhongxun;Li Bing;Huang Huijun;Qin Tiejun;Xu Zefeng;Zhang Hongli;Fang Liwei;Pan Lijuan;Hu Naibo;Qu Shiqiang;Huang Gang;Gale Robert P;Xiao Zhijian |
| 22 | 伴TP53基因异常骨髓增生异常综合征患者的临床特征及预后研究 | 期刊论文 | 黄慧君;史仲珣;李冰;秦铁军;徐泽锋;张宏丽;方力维;胡耐博;潘丽娟;曲士强;刘丹;蔡亚楠;张瑜堤;肖志坚 |
| 23 | 芦可替尼联合泼尼松、沙利度胺和达那唑治疗骨髓纤维化的探索性研究 | 期刊论文 | 徐泽锋;秦铁军;张宏丽;方力维;潘丽娟;胡耐博;曲士强;李冰;肖志坚 |
| 24 | 芦可替尼治疗骨髓纤维化:不良反应及治疗失败对策研究 | 期刊论文 | 严欣;徐泽锋;肖志坚 |
| 25 | 《真性红细胞增多症诊断与治疗中国专家共识(2016年版)》解读 | 期刊论文 | 史仲珣;肖志坚 |
| 26 | Bone marrow fibrosis grade is an independent risk factor for overall survival in patients with primary myelofibrosis | 期刊论文 | Li B.;Zhang P.;Feng G.;Xu Z.;Qin T.;Zhang Y.;Sha Z.;Dong D.;Zhang H.;Fang L.;Pan L.;Hu N.;Qu S.;Cai W.;Huang G.;Xiao Z. |
| 27 | Severe ineffective erythropoiesis discriminates prognosis in myelodysplastic syndromes: analysis based on 776 patients from a single centre | 期刊论文 | Huang Huijun;Xu Changlu;Gao Jie;Li Bing;Qin Tiejun;Xu Zefeng;Ren Sirui;Zhang Yudi;Jiao Meng;Qu Shiqiang;Pan Lijuan;Hu Naibo;Liu Jinqin;Cai Wenyu;Zhang Yingnan;Wu Dan;Zhang Peihong;Gale Robert Peter;Huang Gang;Zhou Jiaxi;Shi Lihong;Xiao Zhijian |
| 28 | 伴环状铁粒幼红细胞增多骨髓增生异常综合征基因突变特征及临床意义 | 期刊论文 | 蔡亚楠;徐泽锋;李冰;秦铁军;潘丽娟;曲士强;胡耐博;刘丹;黄慧君;史仲珣;张瑜堤;肖志坚 |
| 29 | Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models | 期刊论文 | Wang Jieyu;Hayashi Yoshihiro;Yokota Asumi;Xu Zefeng;Zhang Yue;Huang Rui;Yan Xiaomei;Liu Hongyun;Ma Liping;Azam Mohammad;Bridges James P.;Cancelas Jose A.;Kalfa Theodosia A.;An Xiuli;Xiao Zhijian;Huang Gang |
| 30 | Long-term outcomes of imatinib in patients with FIP1L1/PDGFRA associated chronic eosinophilic leukemia: experience of a single center in china | 期刊论文 | Qu Shi-Qiang;Qin Tie-Jun;Xu Ze-Feng;Zhang Yue;Ai Xiao-fei;Li Bing;Zhang Hong-Li;Fang Li-Wei;Pan Li-Juan;Hu Nai-Bo;Xiao Zhi-Jian |
| 31 | 615例Ph染色体/BCR-ABL融合基因阴性骨髓增殖性肿瘤患者的症状负荷评估 | 期刊论文 | 徐俊卿;徐泽锋;王静雅;李冰;孙秀娟;秦铁军;张悦;张宏丽;方力维;潘丽娟;胡耐博;曲士强;肖志坚 |
| 32 | JAK2、MPL和CALR基因突变在中国原发性骨髓纤维化患者中的预后意义 | 期刊论文 | 徐泽锋;李冰;刘晋琴;李艳;艾晓非;张培红;秦铁军;张悦;王静雅;徐俊卿;张宏丽;方力维;潘丽娟;胡耐博;曲士强;肖志坚 |
| 33 | A novel fusion of PDGFRB to TSC1, an intrinsic suppressor of mTOR-signaling pathway, in a chronic eosinophilic leukemia patient with t(5;9)(q32;q34) | 期刊论文 | Zhang Yue;Qu Shiqiang;Wang Qianfei;Li Jianyong;Xu Zefeng;Qin Tiejun;Huang Gang;Xiao Zhijian |
| 34 | 我国骨髓增殖性肿瘤诊治应引起重视的几个问题 | 期刊论文 | 肖志坚 |
| 35 | 免疫调节剂治疗骨髓纤维化研究进展 | 期刊论文 | 张喻堤;徐泽锋;肖志坚 |
| 36 | 慢性中性粒细胞白血病临床和实验室特征及预后因素分析 | 期刊论文 | 崔亚娟;江倩;刘晋琴;李冰;徐泽锋;秦铁军;张悦;蔡文宇;张宏丽;方力维;潘丽娟;胡耐博;曲士强;肖志坚 |
| 37 | The different prognostic impact of type-1 or type-1 like and type-2 or type-2 likeCALRmutations in patients with primary myelofibrosis | 期刊论文 | Bing Li;Zefeng Xu;Yan Li;Robert Peter Gale;Zhen Song;Xiaofei Ai;Tiejun Qin;Yue Zhang;Peihong Zhang;Gang Huang;Zhijian Xiao |
| 38 | Elimination of Autofluorescence in Archival Formaldehyde-Fixed, Paraffin-Embedded Bone Marrow Biopsies | 期刊论文 | Su Wenxia;Yang Lin;Luo Xueping;Chen Meng;Liu Jinqin |
| 39 | The usefulness of mutational data on prognosis of myelodysplastic syndromes: alone or incorporated into the IPSS-R? | 期刊论文 | Bing Li;Jinqin Liu;Zefeng Xu;Tiejun Qin;Zhongxun Shi;Zhen Song;Huijun Huang;Liwei Fang;Hongli Zhang;Lijuan Pan;Naibo Hu;Shiqiang Qu;Yue Zhang;Gang Huang;Zhijian Xiao |
| 40 | Thalidomide plus prednisone with or without danazol therapy in myelofibrosis: a retrospective analysis of incidence and durability of anemia response | 期刊论文 | Luo Xueping;Xu Zefeng;Li Bing;Qin Tiejun;Zhang Peihong;Zhang Hongli;Fang Liwei;Pan Lijuan;Hu Naibo;Qu Shiqiang;Zhang Yue;Huang Gang;Gale Robert Peter;Xiao Zhijian |
| 41 | Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes | 期刊论文 | Hayashi Yoshihiro;Zhang Yue;Yokota Asumi;Yan Xiaomei;Liu Jinqin;Choi Kwangmin;Li Bing;Sashida Goro;Peng Yanyan;Xu Zefeng;Huang Rui;Zhang Lulu;Freudiger George M.;Wang Jingya;Dong Yunzhu;Zhou Yile;Wang Jieyu;Wu Lingyun;Bu Jiachen;Chen Aili;Zhao Xinghui;Sun Xiujuan;Chetal Kashish;Olsson Andre;Watanabe Miki;Romick-Rosendale Lindsey E.;Harada Hironori;Shih Lee-Yung... |
| 42 | 原发性骨髓纤维化预后评分系统的研究现状 | 期刊论文 | 吴君颖;肖志坚 |
| 43 | Mutational features of myelodysplastic syndromes with Auer rods reveal them are more akin to acute myeloid leukemia | 期刊论文 | Huang Huijun;Qin Tiejun;Xu Zefeng;Shi Zhongxun;Li Bing;Pan Lijuan;Hu Naibo;Qu Shiqiang;Huang Gang;Gale Robert P.;Xiao Zhijian |
| 44 | 平均红细胞体积≤100f1是骨髓原始细胞<5%骨髓增生异常综合征患者的独立预后因素 | 期刊论文 | 史仲珣;秦铁军;徐泽锋;黄慧君;李冰;曲士强;胡耐博;潘丽娟;刘丹;蔡亚楠;张喻堤;肖志坚 |
| 45 | 我如何治疗原发性骨髓纤维化 | 期刊论文 | 肖志坚 |
| 46 | 原发性骨髓纤维化和骨髓增生异常综合征伴骨髓纤维化患者纤维驱动细胞的研究 | 期刊论文 | 蔡亚楠;张培红;方立环;刘晋琴;李冰;徐泽锋;秦铁军;肖志坚 |
| 47 | JAK1抑制剂SHR0302和芦可替尼对骨髓增殖性肿瘤SET2细胞系和原代细胞增殖抑制和抗炎作用机制的研究 | 期刊论文 | 杨爱莹;刘晋琴;蔡亚楠;方美云;杨琳;陈猛;李冰;肖志坚 |
| 48 | 地西他滨单药与CAG/HAG方案治疗难治性贫血伴有原始细胞增多的疗效和安全性比较 | 期刊论文 | 徐泽锋;秦铁军;张宏丽;方力维;张悦;潘丽娟;胡耐博;曲士强;李冰;肖志坚 |
| 49 | Colony-forming unit cell (CFU-C) assays at diagnosis: CFU-G/M cluster predicts overall survival in myelodysplastic syndrome patients independently of IPSS-R | 期刊论文 | Li Bing;Liu Jinqin;Qu Shiqiang;Gale Robert Peter;Song Zhen;Xing Ruixian;Liu Junxia;Ren Yansong;Xu Zefeng;Qin Tiejun;Zhang Yue;Fang Liwei;Zhang Hongli;Pan Lijuan;Hu Naibo;Cai Wenyu;Zhang Peihong;Huang Gang;Xiao Zhijian |
查看更多信息请先登录或注册
