急性髓系白血病细胞干性的调控机制及干预策略
81430004
2014
H0809.白血病
王建祥
重点项目
教授
中国医学科学院
300万元
急性髓系白血病;诱导多能干细胞;干性;造血微环境;靶向治疗
2015-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Reprogramming of Notch1-induced acute lymphoblastic leukemia cells into pluripotent stem cells in mice | 期刊论文 | Zhang H;Cheng H;Wang Y;Zheng Y;Liu Y;Liu K;Xu J;Hao S;Yuan W;Zhao T;Cheng T |
| 2 | Targeting FLT3 in acute myeloid leukemia using ligand-based chimeric antigen receptor-engineered T cells | 期刊论文 | Wang Ying;Xu Yingxi;Li Saisai;Liu Jia;Xing Yanyan;Xing Haiyan;Tian Zheng;Tang Kejing;Rao Qing;Wang Min;Wang Jianxiang |
| 3 | Antineoplastic effects and mechanisms of micheliolide in acute myelogenous leukemia stem cells. | 期刊论文 | Ji Qing;Ding Ya-Hui;Sun Yue;Zhang Yu;Gao Hui-Er;Song He-Nan;Yang Ming;Liu Xiao-Lei;Zhang Zi-Xiang;Li Ying-Hui;Gao Ying-Dai |
| 4 | StemCellCKB: An Integrated Stem Cell-Specific Chemogenomics KnowledgeBase for Target Identification and Systems-Pharmacology Research | 期刊论文 | Zhang Yu;Wang Lirong;Feng Zhiwei;Cheng Haizi;McGuire Terence Francis;Ding Yahui;Cheng Tao;Gao Yingdai;Xie Xiang Qun |
| 5 | c-MPL Is a Candidate Surface Marker and Confers Self-Renewal, Quiescence, Chemotherapy Resistance, and Leukemia Initiation Potential in Leukemia Stem Cells. | 期刊论文 | Li Huan;Zhao Na;Li Yihui;Xing Haiyan;Chen Shuying;Xu Yingxi;Tang Kejing;Tian Zheng;Wang Min;Rao Qing;Wang Jianxiang |
| 6 | Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells | 期刊论文 | Ding Yahui;Gao Huier;Zhang Yu;Li Ye;Vasdev Neil;Gao Yingdai;Chen Yue;Zhang Quan |
| 7 | Randomized trial of intermediate-dose cytarabine in induction and consolidation therapy in adults with acute myeloid leukaemia | 期刊论文 | Hui Wei;Ying Wang;Robert Peter Gale;Dong Lin;Chunlin Zhou;Bingcheng Liu;Shaowei Qiu;Runxia Gu;Yan Li;Xingli Zhao;Shuning Wei;Benfa Gong;Kaiqi Liu;Xiaoyuan Gong;Yuntao Liu;Guangji Zhang;Zhen Song;Yang Wang;Wei Li;Yingchang Mi;王建祥 |
| 8 | 'Waterloo': when normal blood cells meet leukemia | 期刊论文 | Cheng Hui;Cheng Tao |
| 9 | Identification of JL1037 as a novel, specific, reversible lysine-specific demethylase 1 inhibitor that induce apoptosis and autophagy of AML cells | 期刊论文 | Liu Shuang;Lu Wenting;Li Shouyun;Li Saisai;Liu Jia;Xing Yuanyuan;Zhang Shuzu;Zhou Joe Zhongxiang;Xing Haiyan;Xu Yingxi;Rao Qing;Deng Chengjun;Wang Min;Wang Jianxiang |
| 10 | The number of CD34 CD38 CD117 HLA-DR CD13 CD33 cells indicates post-chemotherapy hematopoietic recovery in patients with acute myeloid leukemia | 期刊论文 | Gu Runxia;Wei Hui;Wang Ying;Lin Dong;Liu Bingcheng;Zhou Chunlin;Liu Kaiqi;Gong Benfa;Wei Shuning;Zhang Guangji;Gong Xiaoyuan;Liu Yuntao;Li Yan;Zhao Xingli;Qiu Shaowei;Wang Huijun;Wang Min;Mi Yingchang;Wang Jianxiang |
| 11 | Bone marrow endothelial cell-derived interleukin-4 contributes to thrombocytopenia in acute myeloid leukemia | 期刊论文 | Gao Ai;Gong Yuemin;Zhu Caiying;Yang Wanzhu;Li Qing;Zhao Mei;Ma Shihui;Li Jianyong;Hao Sha;Cheng Hui;Cheng Tao |
| 12 | Up-regulated A20 promotes proliferation, regulates cell cycle progression and induces chemotherapy resistance of acute lymphoblastic leukemia cells | 期刊论文 | Shuying Chen;Haiyan Xing;Shouyun Li;Jing Yu;Huan Li;Shuang Liu;Zheng Tian;Kejing Tang;Qing Rao;Min Wang;Jianxiang Wang |
| 13 | Leukemic marrow infiltration reveals a novel role for Egr3 as a potent inhibitor of normal hematopoietic stem cell proliferation | 期刊论文 | Cheng Hui;Hao Sha;Liu Yanfeng;Pang Yakun;Ma Shihui;Dong Fang;Xu Jing;Zheng Guoguang;Li Shaoguang;Yuan Weiping;Cheng Tao |
| 14 | Megakaryocyte-derived excessive transforming growth factor beta 1 inhibits proliferation of normal hematopoietic stem cells in acute myeloid leukemia | 期刊论文 | Gong Yuemin;Zhao Mei;Yang Wanzhu;Gao Ai;Yin Xiuxiu;Hu Linping;Wang Xiaofang;Xu Jing;Hao Sha;Cheng Tao;Cheng Hui |
| 15 | Leukemia cell infiltration causes defective erythropoiesis partially through MIP-1 alpha/CCL3 | 期刊论文 | Wang Y;Gao A;Zhao H;Lu P;Cheng H;Dong F;Gong Y;Ma S;Zheng Y;Zhang H;Zhang Y;Xu J;Zhu X;Yuan W;Zhang X;Hao S;Cheng T |
| 16 | Precision therapy for acute myeloid leukemia | 期刊论文 | Yang Xue;Wang Jianxiang |
| 17 | A novel lymphoid progenitor cell population (LSKlow) is restricted by p18(INK4c) | 期刊论文 | Dong Fang;Hao Sha;Ma Shihui;Cheng Hui;Wang Yajie;Zhou Wen;Yuan Weiping;Ema Hideo;Cheng Tao |
| 18 | Altered mesenchymal niche cells impede generation of normal hematopoietic progenitor cells in leukemic bone marrow | 期刊论文 | Lim M;Pang Y;Ma S;Hao S;Shi H;Zheng Y;Hua C;Gu X;Yang F;Yuan W;Cheng T |
| 19 | Induced CD20 Expression on B-Cell Malignant Cells Heightened the Cytotoxic Activity of Chimeric Antigen Receptor Engineered T Cells | 期刊论文 | Xu Yingxi;Li Saisai;Wang Ying;Liu Jia;Mao Xinhe;Xing Haiyan;Tian Zheng;Tang Kejing;Liao Xiaolong;Rao Qing;Xiong Dongsheng;Wang Min;Wang Jianxiang |
| 20 | ZFP36L2, a novel AML1 target gene, induces AML cells apoptosis and inhibits cell proliferation | 期刊论文 | Liu Jia;Lu Wenting;Liu Shuang;Wang Ying;Li Saisai;Xu Yingxi;Xing Haiyan;Tang Kejing;Tian Zheng;Rao Qing;Wang Min;Wang Jianxiang |
| 21 | Rac1 GTPase Promotes Interaction of Hematopoietic Stem/Progenitor Cell with Niche and Participates in Leukemia Initiation and Maintenance in Mouse | 期刊论文 | Chen S;Li H;Li S;Yu J;Wang M;Xing H;Tang K;Tian Z;Rao Q;Jianxiang Wang |
| 22 | Loss of Dnmt3b accelerates MLL-AF9 leukemia progression | 期刊论文 | Zheng Y;Zhang H;Wang Y;Li X;Lu P;Dong F;Pang Y;Ma S;Cheng H;Hao S;Tang F;Yuan W;Zhang X;Cheng T |
| 23 | Targeting of apoptosis gene loci by reprogramming factors leads to selective eradication of leukemia cells | 期刊论文 | Wang Yajie;Lu Ting;Sun Guohuan;Zheng Yawei;Yang Shangda;Zhang Hongyan;Hao Sha;Liu Yanfeng;Ma Shihui;Zhang Houyu;Ru Yongxin;Gao Shaorong;Yen Kuangyu;Cheng Hui;Cheng Tao |
| 24 | New paradigms on hematopoietic stem cell differentiation. | 期刊论文 | Cheng Hui;Zheng Zhaofeng;Cheng Tao |
| 25 | Mitochondrial dysfunction and oxidative stress in bone marrow stromal cells induced by daunorubicin leads to DNA damage in hematopoietic cells | 期刊论文 | Yihui Li;Zhenya Xue;Jiaxuan Dong;Qian Liu;Zhe Liu;Huan Li;Haiyan Xing;Yingxi Xu;Kejing Tang;Zheng Tian;Min Wang;Qing Rao;王建祥 |
| 26 | A novel SAHA-bendamustine hybrid induces apoptosis of leukemia cells | 期刊论文 | Jing Yu;Shaowei Qiu;Qiufu Ge;Ying Wang;Hui Wei;Dianwu Guo;Shuying Chen;Shuang Liu;Shouyun Li;Haiyan Xing;Qing Rao;Jianxiang Wang;Min Wang |
| 27 | CD33-Specific Chimeric Antigen Receptor T Cells with Different Co-Stimulators Showed Potent Anti-Leukemia Efficacy and Different Phenotype | 期刊论文 | Li Saisai;Tao Zhongfei;Xu Yingxi;Liu Jia;An Na;Wang Ying;Xing Haiyan;Tian Zheng;Tang Kejing;Liao Xiaolong;Rao Qing;Wang Min;Wang Jianxiang |
| 28 | Novel regulators in hematopoietic stem cells can be revealed by a functional approach under leukemic condition | 期刊论文 | Cheng H;Liu Y;Jia Q;Ma S;Yuan W;Jia H;Cheng T |
| 29 | Distinct genetic alteration profiles of acute myeloid leukemia between Caucasian and Eastern Asian population | 期刊论文 | Wei Hui;Wang Ying;Zhou Chunlin;Lin Dong;Liu Bingcheng;Liu Kaiqi;Qiu Shaowei;Gong Benfa;Li Yan;Zhang Guangji;Wei Shuning;Gong Xiaoyuan;Liu Yuntao;Zhao Xingli;Gu Runxia;Mi Yingchang;Wang Jianxiang |
| 30 | Antineoplastic effects of CPPTL via the ROS/JNK pathway in acute myeloid leukemia | 期刊论文 | Gao Hui er;Sun Yue;Ding Ya hui;Long Jing;Liu Xiao lei;Yang Ming;Ji Qing;Li Ying hui;Chen Yue;Zhang Quan;Gao Ying dai |
| 31 | NK cells play a significant role in immunosurveillance at the early stage of MLL-AF9 acute myeloid leukemia via CD226/CD155 interactions | 期刊论文 | Wang YaJie;Chen Chen;Dong Fang;Ma ShiHui;Xu Jing;Gong YueMin;Cheng Hui;Zhou Yuan;Cheng Tao;Hao Sha |
| 32 | Cell cycle regulation of hematopoietic stem or progenitor cells | 期刊论文 | Hao Sha;Chen Chen;Cheng Tao |
| 33 | Nilotinib combined with multi-agent chemotherapy in newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia: a single-center prospective study with long-term follow-up | 期刊论文 | 2..Bingcheng Liu;Ying Wang;Chunlin Zhou;Hui Wei;Dong Lin;Wei Li;Kaiqi Liu;Guangji Zhang;Shuning Wei;Yan Li;Benfa Gong;Yuntao Liu;Xiaoyuan Gong;Yingchang Mi;王建祥 |
| 34 | An analysis of 97 previously diagnosed de novo adult acute erythroid leukemia patients following the 2016 revision to World Health Organization classification | 期刊论文 | Qiu Shaowei;Jiang Erlie;Wei Hui;Lin Dong;Zhang Guangji;Wei Shuning;Zhou Chunlin;Liu Kaiqi;Wang Ying;Liu Bingcheng;Liu Yuntao;Gong Benfa;Gong Xiaoyuan;Feng Sizhou;Mi Yingchang;Han Mingzhe;Wang Jianxiang |
| 35 | Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells | 期刊论文 | Qiu Shaowei;Liu Shuang;Yu Tengteng;Yu Jing;Wang Min;Rao Qing;Xing Haiyan;Tang Kejing;Mi Yinchang;Wang Jianxiang |
| 36 | RUNX1 inhibits proliferation and induces apoptosis of t(8;21) leukemia cells via KLF4-mediated transactivation of P57 | 期刊论文 | Liu Shuang;Xing Yanyan;Lu Wenting;Li Shouyun;Tian Zheng;Xing Haiyan;Tang Kejing;Xu Yingxi;Rao Qing;Wang Min;Wang Jianxiang |
| 37 | Construction of a new anti-CD19 chimeric antigen receptor and the anti-leukemia function study of the transduced T cells | 期刊论文 | An Na;Tao Zhongfei;Li Saisai;Xing Haiyan;Tang Kejing;Tian Zheng;Rao Qing;Wang Min;Wang Jianxiang |
| 38 | Effects of telomere length on leukemogenesis | 期刊论文 | Ma Shi;Sun G;Yang S;Ju Z;Cheng T;Cheng H |
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