高效快速新颖结构天然产物的发现及其生物活性研究

20432030
2004
B0703.天然产物化学生物学
于德泉
重点项目
研究员
中国医学科学院
200万元
生物活性;新颖结构;天然产物
2005-01-01到2008-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 An Abietane Diterpene and a Sterol from Fungus Phellinus igniarius 期刊论文
2 Chemical constituents from Ampelopsis grossedentata 期刊论文
3 丰城鸡血藤异黄酮类成分的研究 期刊论文
4 Structure and total synthesis of aspernigerin: a novel cytotoxic endophyte metabolite 期刊论文
5 Synthesis and cytotoxic evaluation of a series of genistein derivatives 期刊论文
6 A flavoronoide glucuronide from A belmoschus manihot (L.) Medik 期刊论文
7 天然产物中先导化合物的发现与优化 期刊论文
8 柳叶金叶子根的化学成分研究 期刊论文
9 Two new Diterpenes from Helianthus annuus 期刊论文
10 华山松塔化学成分的研究 期刊论文
11 Chaetoglobins A and B, Two Unusual Alkaloids from Endophytic Chaetomium globosum Culture 期刊论文
12 tructural revision of aspernigrin A, reisolated from Cladosporium herbarum IFB-E002 期刊论文
13 Paranolin: a New Xanthene-Based Metabolite from Paraphaeosphaeria nolinae 期刊论文
14 An Apigenin-Derived Xanthine Oxidase Inhibitor from Palhinhaea cernua 期刊论文
15 Two new isoprenyl chalcones from Hedysarum gmelinii Ledeb 期刊论文
16 Hopeanol: a potent cytotoxin with a novel skeleton from Hopea exalata 期刊论文
17 Lignan Glycosides from Neoalsomitra integrifoliala 期刊论文
18 Five new Diels-Alder type adducts from the stem and root bark of Morus mongolica 期刊论文
19 Cytotoxic benzo[j]fluoranthene metabolites from Hypoxylon truncatum IFB-18, an endophyte of Artemisia annua 期刊论文
20 Diterpenes from Helianthus annuuus and their cytotoxicity invitro 期刊论文
21 Sesquiterpenes from the Red Alga Laurencia tristicha. 期刊论文
22 Three New phenolic glycosides from the caulis of Millettia speciosa 期刊论文
23 长穗桑中的苯并呋喃类化合物 期刊论文
24 A new benzofuranilignan and a new flavonol derivative from the stem of Morus australis 期刊论文
25 Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde 期刊论文
26 A New Stilbene from Cercis chinensis 期刊论文
27 草珊瑚的化学成分研究 期刊论文
28 Rapid structural determination of new trace cassaine-type diterpenoid amides in fractions from Erythrophleum fordii by liquid chromatography-diode-array detection-electrospray ionization tandem mass spectrometry and liquid chromatography-nuclear magnetic 期刊论文
29 Structural characterization of constituents with molecular diversity in fractions from Lysidice brevicalyx by liquid chromatography/diode-array detection/electrospray ionization tandem mass spectrometry and liquid chromatography/nuclear magnetic resonance 期刊论文
30 鸡血藤黄酮类化合物的研究 期刊论文
31 Bromophenols Coupled with Methyl γ-Ureidobutyrate and Bromophenol Sulfates from the Red Alga Rhodomela confervoides 期刊论文
32 Cyclolanostane triterpene glycosides from Souliea vaginata 期刊论文
33 红血藤的化学成分 期刊论文
34 合欢皮中两个新八糖苷的分离鉴定和活性研究 期刊论文
35 Sesquiterpenes from Red Alga Laurencia tristicha 期刊论文
36 松塔化学成分的研究 期刊论文
37 Saponins from the roots of Hedysarum polybotrys 期刊论文
38 Resveratrol/Phloroglucinol glycosides from the roots of Lysidice rhodostegia. 期刊论文
39 酚酸化学 专著
40 A Nitrogen-Containing 3-Alkyl-1,4-benzoquinone and a Gomphilactone Derivative from Embelia ribes 期刊论文
41 BACE1 ((-secretase) Inhibitory Chromone Glycosides from Aloe sp. plant. 期刊论文
42 A new triterpene from cynanchum forrestii. 期刊论文
43 Five new cytotoxic triterpenoid saponins from the roots of Symplocos chinensis 期刊论文
44 天山岩黄芪化学成分研究 期刊论文
45 SPE-HPLC method for the determination of four flavonols in rat plasma and urine after oral administration of Abelmoschus manihot extract 期刊论文
46 Two new compounds from the stem of Vernonia cumingiana. 期刊论文
47 Phelligridimer A, A Highly Oxygenated and Unsaturated Twenty-Six Membered Macrocyclic Metabolite with Antioxidant Activity from the Fungus Phellinus igniarius 期刊论文
48 Two new sesquiterpene lactones from Sarcandra glabra 期刊论文
49 New dibenz[b, f]oxepins from Cercis chinensis Bunge 期刊论文
50 滇桑茎皮种抗氧化活性成分研究 期刊论文
51 Bioactive Oligostilbenoids from the Stem Bark of Hopea exalata 期刊论文
52 Penicidones A-C, three cytotoxic alkaloidal metabolites of an endophytic Penicillium sp. 期刊论文
53 Chemical constituents of the red alga Laurencia tristicha 期刊论文
54 Minor Sesquiterpenes with New Carbon Skeletons from the Brown Alga Dictyopteris diWaricata 期刊论文
55 Targeted Isolation and Structure Elucidation of Stilbene Glycosides from the Bark of Lysidice brevicalyx Wei Guided by Biological and Chemical Screening 期刊论文
56 芦荟属药用植物的化学成分和药理活性 期刊论文
57 A new glycoside from the leaves of Neoalsomitra integrifoliola. 期刊论文
58 Chaetoglobosin U, a cytochalasan alkaloid from endophytic Chaetomium globosum IFB-E019. 期刊论文
59 An antitumor compound julibroside J28..from Albizia julibrissin. 期刊论文
60 中药补骨脂化学成分的研究 期刊论文
61 Stability and structure studies on alisol A 24-acetate. Bolat MAKABEL 期刊论文
62 Studies on chemical constituets from Ilex pubescens 期刊论文
63 乌桕叶化学成分研究 期刊论文
64 Isolation and identification of metabolites from dihydromyricetin 期刊论文
65 Three antitumor saponins from Albizia julibrissin 期刊论文
66 A Unique Highly Oxygenated Pyrano[4,3-c][2]benzopyran-1,6- dione Derivative with Antioxidant and Cytotoxic Activities from the Fungus Phellinus igniarius 期刊论文
67 Synthesis and cytotoxic evaluation of a series of resveratrol derivatives modified in C2 position 期刊论文
68 Iridoid glycosides and grayanane diterpenoids from roots of Craibiodendron henryi. 期刊论文
69 Glycosides from the Bark of Adina polycephala 期刊论文
70 A new cyclantane Triterpene glycoside from Souliea vaginata 期刊论文
71 大理白前化学成分研究 期刊论文
72 Norsesquiterpenes from the Brown Alga Dictyopteris divaricata 期刊论文
73 中药苦参主要黄酮类成分的研究 期刊论文
74 Antioxidant properties and PC12 cell protective effects of APS-1, a polysaccharide from Aloe vera var. chinensis 期刊论文
75 鸡桑糖苷类化学成分研究 期刊论文
76 香花崖豆藤中异黄酮类化合物的研究. 期刊论文
77 鸡桑中化学成分及抗癌和抗氧化活性研究 期刊论文
78 Two new flavanonol glycosides from Gordonia chrysandra. 期刊论文
79 Synthesis and cytotoxic evaluation of a series of resveratrol derivatives 期刊论文
80 Bromophenols Coupled with Derivatives of Amino Acids and Nucleosides from the Red Alga Rhodomela confervoides 期刊论文
81 Glucosides from the roots of Capparis tenera. 期刊论文
82 Quantification and stability studies on the flavonoids of Radix hedysari 期刊论文
83 Terpenoids from the tuber of Cremastra appendiculata 期刊论文
84 金不换的化学成分研究 期刊论文
85 Triterpenoid saponins with neuroprotective effects from the roots of Polygala tenuifolia. 期刊论文
86 Seven new steroidal glycosides from the roots of Cynanchum forrestii 期刊论文
87 Two new Norisoprenoid Derivatives from the Red Alga Gymnogongrus flabelliformis 期刊论文
88 黄蜀葵花化学成分的研究 期刊论文
89 A new Diels-Alder type adduct and a new flavone from the stem and root bark of Morus mongolica 期刊论文
90 Structures, Biogenesis, and Biological Activities of Pyrano[4,3-c]isochromen-4-one Derivatives from the Fungus Phellinus igniarius 期刊论文
91 Neoplaether, a new cytotoxic and antifungal endophyte metabolite from Neoplaconema napellum IFB-E016 期刊论文
92 Oligosaccharide polyester and triterpenoid saponins from the roots of Polygala japonica 期刊论文
93 Mono-, Bi-, and Triphenanthrenes from the Tubers of Cremastra appendiculata. 期刊论文
94 Three new xanthones from the roots of Polygala japonica Houtt 期刊论文
95 Chromatographic Fingerprint Analysis of the Flowers of Abelmoschus manihot Using HPLC with Photodiode Array Detection 期刊论文
96 宽叶金粟兰化学成分的研究 期刊论文
97 Julibroside J8-induced HeLa cell apoptosis through caspase pathway 期刊论文
98 Cucurbitane triterpenoids from Momordica charantia 期刊论文
99 Eight new C-21 steroidal glycosides from Dregea sinensis var. corrugate 期刊论文
100 Flavonoids from the roots of Hedysarum gmelinii 期刊论文
101 向日葵属植物倍半萜类化学成分及其生物活性研究概况 期刊论文
102 黑桑茎皮化学成分研究 期刊论文
103 Four 6H-dibenzo[b,d]pyran-6-one derivatives produced by the endophyte Cephalosporium acremonium IFB-E007 期刊论文
104 毛冬青的化学成分研究 期刊论文
105 Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015 期刊论文
106 A New Halogenated Biindole and A New Apo-carotenone from Green Alga Chaetomorpha basiretorsa 期刊论文
107 Pyridinium Alkaloid-Coupled Secoiridoids from the Flower Buds of Lonicera japonica 期刊论文
108 大鼠灌胃棉花皮素-8-O-葡萄糖醛酸苷后血清中药物的分析 期刊论文
109 黄三七皂苷类化学成分 期刊论文
110 Hopeahainol A, an acetylcholinesterase inhibitor from Hopea hainanensis 期刊论文
111 远志属植物的皂苷类成分及其药理作用研究进展 期刊论文
112 Simultaneous determination of seven flavonoids in Potentilla multifida by HPLC 期刊论文
113 Steroidal glycosides from Cynanchum forrestii Schlechter 期刊论文
114 三萜化学 专著
115 Simultaneous determination and pharmacokinetic studies of dihydromyricetin and myricetin in rat plasma by HPLC-DAD after oral administration of Ampelopsis grossedentata decoction 期刊论文
116 功能海洋生物分子-发现与应用 专著
117 Three new compounds from the barks of Morus nigra 期刊论文
118 Cytotoxic Oxygenated Triterpenoid Saponins from Symplocos chinensis 期刊论文
119 Triterpenoids form the roots of Craibiodendron henryi W. W. Smith. 期刊论文
120 Nine novel C-21 steroidal glycosides substituted with orthoacetate from Dregea sinensis var.corrugata 期刊论文
121 Absolute configuration of new cytotoxic and other bioactive trichothecene macrolides 期刊论文
122 木立芦荟中BACE抑制活性成分的研究 期刊论文
123 Hepatoprotective sesquiterpene glycoside from Sarcandra glabra 期刊论文
124 Spinosin, a C-glycoside .avonoid from semen Zizhiphi Spinozae, potentiated pentobarbital-induced sleep via the serotonergic system 期刊论文
125 Novel phloroglucinol derivatives from the roots of lysidice rhodostegia 期刊论文
126 Acetylated flavonol diglucosides from Meconopsis quintuplinervia 期刊论文
127 Chemical constituents of the roots of Vernonia cumingiana Benth 期刊论文
128 Glycosides from the Stem Bark of Fraxinus sieboldiana 期刊论文
129 A novel phenylpropanoid-substituted catechin glycoside and a new dihydrochalcone from Sarcandra glabra 期刊论文
130 高效液相法测定不同产地鸡血藤药材中黄酮类化合物的含量 期刊论文
131 New resveratrol oligomers from the stem bark of Hopea hainanensis 期刊论文
132 Cephalosol, an Antimicrobial Metabolite with an Unprecedented Skeleton from Endophytic Cephalosporium acremonium IFB-E007 期刊论文
133 柳叶金叶子叶的化学成分研究 期刊论文
134 蒙桑茎皮中Dials-Alder型加合物化学成分的研究 期刊论文
135 Glycosides from the Root of Iodes cirrhosa 期刊论文
136 紫荆化学成分的研究 期刊论文
137 绒毛阴地蕨石油醚部分化学成分研究 期刊论文
138 Cytotoxic Triterpenoid Saponins Acylated with Monoterpenic Acid from Pithecellobium lucidum 期刊论文
139 wo new cycloartane triterpene glycosides and a new alkaloid from Souliea vaginata 期刊论文
140 Unprecedented immunosuppressive polyketides from Daldinia eschscholzii, a mantis-associated fungus 期刊论文
141 Three new cytotoxic Diels-Alder type adducts from Morus australis 期刊论文
142 Synthesis and cytotoxic evaluation of novel 7-O-modified Genistein derivatives 期刊论文
143 Two Novel Glycosidic Triterpene Alkaloids from the Stem Barks of Machilus yaoshansis 期刊论文
144 斑鸠菊属的倍半萜内酯类及甾体皂苷类化学成分及药理活性研究进展. 期刊论文
145 A new cucurbitane triterpenoids from Momordica charantia. 期刊论文
146 A new glycoside from the leaves of Neoalsomitra integrifoliola. 期刊论文
147 Three new cytotoxic Diels-Alder type adducts from Morus australis 期刊论文
148 鸡桑糖苷类化学成分研究 期刊论文
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