mGluR1在蛛网膜下腔出血后脑损伤中的作用、分子机制及药物调控研究

81671141
2016
H0906.脑血管结构、功能异常及相关疾病
张宗勇
面上项目
教授
山东第一医科大学
57万元
蛛网膜下腔出血;代谢性谷氨酸受体1;脑损伤;谷氨酸
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Ifenprodil减轻大鼠蛛网膜下腔出血后脑水肿及皮质凋亡 期刊论文 密琼洁;韩萍;孙保亮;张宗勇
2 代谢型谷氨酸受体负向变构剂JNJ16259685对蛛网膜下腔出血大鼠神经元的保护作用 期刊论文 张程;谢荣霞;孙保亮;张宗勇
3 Roflumilast Reduces Cerebral Inflammation in a Rat Model of Experimental Subarachnoid Hemorrhage 期刊论文 Wu Qingjian;Qi Lifeng;Li Hanxia;Mao Leilei;Yang Mingfeng;Xie Rongxia;Yang Xiaoyi;Wang Jian;Zhang Zongyong;Kong Jiming;Sun Baoliang
4 Carnosine Attenuates Brain Oxidative Stress and Apoptosis After Intracerebral Hemorrhage in Rats 期刊论文 Xie Rong-Xia;Li Da-Wei;Liu Xi-Chang;Yang Ming-Feng;Fang Jie;Sun Bao-Liang;Zhang Zong-Yong;Yang Xiao-Yi
5 Selective mGluR1 Negative Allosteric Modulator Reduces Blood-Brain Barrier Permeability and Cerebral Edema After Experimental Subarachnoid Hemorrhage. 期刊论文 Zhang Cheng;Jiang Ming;Wang Wei-Qi;Zhao Shi-Jun;Yin Yan-Xin;Mi Qiong-Jie;Yang Ming-Feng;Song Yu-Qiang;Sun Bao-Liang;Zhang Zong-Yong
6 The GluN1/GluN2B NMDA receptor and metabotropic glutamate receptor 1 negative allosteric modulator has enhanced neuroprotection in a rat subarachnoid hemorrhage model. 期刊论文 Zhang Zongyong;Liu Junke;Fan Cundong;Mao Leilei;Xie Rongxia;Wang Suyun;Yang Mingfeng;Yuan Hui;Yang Xiaoyi;Sun Jingyi;Wang Jian;Kong Jiming;Huang Siluo;Sun Baoliang
7 Combination therapy of Ifenprodil and JNJ16259685 improves neurological outcome in a rat subarachnoid hemorrhage model by limiting glutamate excitotoxicity-induced calcium overloading and neuronal apoptosis 会议论文 张宗勇
8 TAT-mGluR1 Attenuation of Neuronal Apoptosis through Prevention of MGluR1alpha Truncation after Experimental Subarachnoid Hemorrhage. 期刊论文 Wang Weiqi;Han Ping;Xie Rongxia;Yang Mingfeng;Zhang Cheng;Mi Qiongjie;Sun Baoliang;Zhang Zongyong
9 Early High Cerebrospinal Fluid Glutamate: A Potential Predictor for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage 期刊论文 Hong-bin Wang;Qing-jian Wu;Shi-jun Zhao;Ya-jun Hou;Han-xia Li;Ming-feng Yang;Bao-jun Wang;Bao-liang Sun;zong-yong Zhang
10 TAT-MGLUR1 Attenuates Neuronal Apoptosis Through Preventing MGLUR1α Truncation After Experimental Subarachnoid Hemorrhage 会议论文 张宗勇
11 Negative Allosteric Modulator of mGluR1 Improves Long-Term Neurologic Deficits after Experimental Subarachnoid Hemorrhage. 期刊论文 Wang Hong-Bin;Wang Wei-Qi;Wu Qing-Jian;Hou Ya-Jun;Li Han-Xia;Yang Hui-Juan;Yang Ming-Feng;Sun Bao-Liang;Zhang Zong-Yong
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