基于多组学的毒作用模式对亚硝胺暴露致食管癌风险研究

81872588
2018
H3001.环境卫生
尹立红
面上项目
教授
东南大学
59万元
食管癌;风险评估;亚硝胺;多组学;生物标志
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Dysregulation of fatty acid metabolism associated with esophageal inflammation of ICR mice induced by nitrosamines exposure 期刊论文 Hu Zhang;Chao Zhao;Qiwei Liu;Ying Zhang;Kai Luo;Yuepu Pu;Lihong Yin
2 Urinary exposure of N-nitrosamines and associated risk of esophageal cancer in a high incidence area in China 期刊论文 Zhao Chao;Zhou Jingjing;Gu Yun;Pan Enchun;Sun Zhongming;Zhang Hu;Lu Qiang;Zhang Ying;Yu Xiaojin;Liu Ran;Pu Yuepu;Yin Lihong
3 Infection with Human Papillomavirus 18 Promotes Alkylating Agent-Induced Malignant Transformation in a Human Esophageal Cell Line 期刊论文 Zhang Ying;Li Yinan;Pan Enchun;Zhao Chao;Zhang Hu;Liu Ran;Wang Shizhi;Pu Yuepu;Yin Lihong
4 长链非编码RNA-GK3P在食管癌中的表达及其对癌细胞生物学功能的影响 期刊论文 周静静;顾云;张龙;张颖;赵超;陆强;张虎;浦跃朴;尹立红
5 Synergistic Carcinogenesis of HPV18 and MNNG in Het-1A Cells through p62-KEAP1-NRF2 and PI3K/AKT/mTOR Pathway 期刊论文 Zhang Ying;Ma Yue;Zhao Chao;Zhang Hu;Pu Yuepu;Yin Lihong
6 LncRNA RPL34-AS1 suppresses the proliferation, migration and invasion of esophageal squamous cell carcinoma via targeting miR-575/ACAA2 axis 期刊论文 Hu Zhang;Enchun Pan;Ying Zhang;Chao Zhao;Qiwei Liu;Yuepu Pu;Lihong Yin
7 Reactive oxygen species‐mediated activation of NLRP3 inflammasome associated with pyroptosis in Het‐1A cells induced by the co‐exposure of nitrosamines 期刊论文 Qiwei Liu;Chao Zhao;Jingjing Zhou;Hu Zhang;Lihong Yin;Shizhi Wang;Yuepu Pu;Lihong Yin
8 Synergism of HPV and MNNG repress miR-218 promoting Het-1A cell malignant transformation by targeting GAB2 期刊论文 Zhang Ying;Zheng Yuhong;Pan Enchun;Zhao Chao;Zhang Hu;Liu Ran;Wang Shizhi;Pu Yuepu;Yin Lihong
9 Lipid metabolism disorders contribute to hepatotoxicity of ICR mice induced by nitrosamines exposure 期刊论文 Hu Zhang;Lu Lu;Chao Zhao;Qiwei Liu;Qian Zhou;Ying Zhang;Yuepu Pu;Shizhi Wang;Ran Liu;Lihong Yin
10 Metabolomic transition trajectory and potential mechanisms of N-nitrosomethylbenzylamine induced esophageal squamous cell carcinoma in rats 期刊论文 Chao Zhao;Hu Zhang;Jingjing Zhou;Qiwei Liu;Qiang Lu;Ying Zhang;Xiaojin Yu;Shizhi Wang;Ran Liu;Yuepu Pu;Lihong Yin
11 HPV联合MNNG对Het-1A细胞恶性转化的影响 期刊论文 马月;郑雨虹;赵超;刘冉;浦跃朴;尹立红
12 The dysregulation of unsaturated fatty acid-based metabolomics in the MNNG-induced malignant transformation of Het-1A cells 期刊论文 Hu Zhang;Qiwei Liu;Chao Zhao;Ying Zhang;Shizhi Wang;Ran Liu;Yuepu Pu;Lihong Yin
13 Distribution of N-nitrosamines in drinking water and human urinary excretions in high incidence area of esophageal cancer in Huai'an 期刊论文 Chao Zhao;Qiang Lu;Yun Gu;Enchun Pan;Zhongming Sun;Hu Zhang;Jingjing Zhou;Ying Du;Ying Zhang;Yuanmei Feng;Ran Liu;Yuepu Pu;Lihong Yin
14 Metabolomics-based molecular signatures reveal the toxic effect of co-exposure to nitrosamines in drinking water 期刊论文 Chao Zhao;Hu Zhang;Jingjing Zhou;Qiang Lu;Lihong Yin;Xiaojin Yu;Shizhi Wang;Ran Liu;Yuepu Pu;Lihong Yin
15 微小RNA-218通过靶向调控LASP1影响食管癌细胞的生物学行为 期刊论文 郑雨虹;马月;张颖;赵超;刘冉;浦跃朴;尹立红
16 Short-term effect of fine particulate matter and ozone on non-accidental mortality and respiratory mortality in Lishui district, China 期刊论文 Yuqi Chen;Zhigang Jiao;Ping Chen;Lijun Fan;Xudan Zhou;Yuepu Pu;Wei Du;Lihong Yin
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