基于CK2和DNA损伤修复的新型四价铂复合物的抗肿瘤机制研究

81503099
2015
H3505.抗肿瘤药物药理
陈飞虹
青年科学基金项目
副教授
东南大学
18万元
铂类化合物;DNA损伤修复;酪蛋白激酶CK2;肿瘤耐药
2016-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Oxidative DNA double strand breaks and autophagy in theantitumor effect of sterically hindered platinum(II) complexesin NSCLCs 期刊论文 Feihong Chen;Xinyi Wang;Xiufeng Jin;Jian Zhao;Shaohua Gou
2 DN604: A platinum(II) drug candidate with classic SAR can induce apoptosis via suppressing CK2-mediated p-cdc25C subcellular localization in cancer cells 期刊论文 Feihong Chen;Xiufeng Jin;Jian Zhao;Shaohua Gou
3 Reversal of cisplatin resistance in human gastric cancer cells by a wogonin-conjugated Pt(IV) prodrug via attenuating Casein Kinase 2-mediated Nuclear Factor-kappa B pathways 期刊论文 Feihong Chen;Xiaodong Qin;Gang Xu;Shaohua Gou;Xiufeng Jin
4 Novel platinum(IV) complexes conjugated with a wogonin derivative as multi-targeted anticancer agents 期刊论文 Xiaodong Qin;Gang Xu;Feihong Chen;Lei Fang;Shaohua Gou
5 Study on the cytotoxic activity of platinum(II) complexes of (1R,2R)-N-1-cyclopentyl-1,2-cyclohexanediamine with substituted malonate derivatives 期刊论文 Zhiping Zhou;Feihong Chen;Gang Xu;Shaohua Gou
6 Hybrid of DNA-targeting Chlorambucil with Pt(IV) Species to Reverse Drug Resistance 期刊论文 Feihong Chen;Gang Xu;Xiaodong Qin;Xiufeng Jin;Shaohua Gou
7 Chemically induced degradation of CK2 by proteolysis targeting chimeras T based on a ubiquitin–proteasome pathway 期刊论文 Hong Chen;Feihong Chen;Nannan Liu;Xinyi Wang;Shaohua Gou
8 A CK2-targeted Pt(IV) prodrug to disrupt DNA damage response 期刊论文 Feihong Chen;Xiaochao Huang;Mian Wu;Shaohua Gou;Weiwei Hu
9 Inhibition of glioblastoma growth and invasion by 125I brachytherapy in rat glioma model 期刊论文 Feihong Chen;Dan Wang
10 Multifunctional Pt(IV) complexes containing a glutathione s- transferase inhibitor lead to enhancing anticancer activity and preventing metastasis of osteosarcoma cells 期刊论文 Hong Chen;Feihong Chen;Xinyi Wang;Shaohua Gou
11 Effective platinum(IV) prodrugs conjugated with lonidamine as a functional group working on the mitochondria 期刊论文 Hong Chen;Feihong Chen;Weiwei Hu;Shaohua Gou
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