Wnt和Notch信号调控椭圆囊Lgr5阳性前体细胞再生毛细胞的研究
81470692
2014
H1404.听觉异常与平衡障碍
柴人杰
面上项目
教授
东南大学
73万元
毛细胞再生;干细胞;Wnt信号通路;毛细胞损伤模型;支持细胞
2015-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea. | 期刊论文 | Chen Yan;Lu Xiaoling;Guo Luo;Ni Wenli;Zhang Yanping;Zhao Liping;Wu Lingjie;Sun Shan;Zhang Shasha;Tang Mingliang;Li Wenyan;Chai Renjie;Li Huawei |
| 2 | The role of FOXG1 in the postnatal development and survival of mouse cochlear hair cells. | 期刊论文 | He Zuhong;Fang Qiaojun;Li He;Shao Buwei;Zhang Yuan;Zhang Yuhua;Han Xiao;Guo Rongrong;Cheng Cheng;Guo Lingna;Shi Lusen;Li Ao;Yu Chenjie;Kong Weijia;Zhao Chunjie;Gao Xia;Chai Renjie |
| 3 | Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea. | 期刊论文 | Liu Liman;Chen Yan;Qi Jieyu;Zhang Yanping;He Yinzi;Ni Wenli;Li Wen;Zhang Shasha;Sun San;Taketo M M;Wang Lei;Chai Renjie;Li Huawei |
| 4 | Accelerating bioelectric functional development of neural stem cells by graphene coupling: Implications for neural interfacing with conductive materials. | 期刊论文 | Guo Rongrong;Zhang Shasha;Xiao Miao;Qian Fuping;He Zuhong;Li Dan;Zhang Xiaoli;Li Huawei;Yang Xiaowei;Wang Ming;Chai Renjie;Tang Mingliang |
| 5 | The structural development of primary cultured hippocampal neurons on a graphene substrate. | 期刊论文 | He Zuhong;Zhang Shasha;Song Qin;Li Wenyan;Liu Dong;Li Huawei;Tang Mingliang;Chai Renjie |
| 6 | HDAC3 Is Required for Posterior Lateral Line Development in Zebrafish. | 期刊论文 | He Yingzi;Wang Zhengmin;Sun Shaoyang;Tang Dongmei;Li Wenyan;Chai Renjie;Li Huawei |
| 7 | c-Myb knockdown increases the neomycin-induced damage to hair-cell-like HEI-OC1 cells in vitro. | 期刊论文 | Yu Xiaoyu;Liu Wenwen;Fan Zhaomin;Qian Fuping;Zhang Daogong;Han Yuechen;Xu Lei;Sun Gaoying;Qi Jieyu;Zhang Shasha;Tang Mingliang;Li Jianfeng;Chai Renjie;Wang Haibo |
| 8 | Co-regulation of the Notch and Wnt signaling pathways promotes supporting cell proliferation and hair cell regeneration in mouse utricles. | 期刊论文 | Wu Jingfang;Li Wenyan;Lin Chen;Chen Yan;Cheng Cheng;Sun Shan;Tang Mingliang;Chai Renjie;Li Huawei |
| 9 | Insm1a Is Required for Zebrafish Posterior Lateral Line Development. | 期刊论文 | He Yingzi;Lu Xiaoling;Qian Fuping;Liu Dong;Chai Renjie;Li Huawei |
| 10 | Inhibition of H3K9me2 Reduces Hair Cell Regeneration after Hair Cell Loss in the Zebrafish Lateral Line by Down-Regulating the Wnt and Fgf Signaling Pathways. | 期刊论文 | Tang Dongmei;Lin Qin;He Yingzi;Chai Renjie;Li Huawei |
| 11 | Regeneration of hair cells in the mammalian vestibular system. | 期刊论文 | Li Wenyan;You Dan;Chen Yan;Chai Renjie;Li Huawei |
| 12 | Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice. | 期刊论文 | Zhu Chengwen;Cheng Cheng;Wang Yanfei;Muhammad Waqas;Liu Shuang;Zhu Weijie;Shao Buwei;Zhang Zhong;Yan Xiaoqian;He Qingqing;Xu Zhengrong;Yu Chenjie;Qian Xiaoyun;Lu Ling;Zhang Shasha;Zhang Yuan;Xiong Wei;Gao Xia;Xu Zhigang;Chai Renjie |
| 13 | LSD1 is Required for Hair Cell Regeneration in Zebrafish. | 期刊论文 | He Yingzi;Tang Dongmei;Cai Chengfu;Chai Renjie;Li Huawei |
| 14 | Meclofenamic Acid Reduces Reactive Oxygen Species Accumulation and Apoptosis, Inhibits Excessive Autophagy, and Protects Hair Cell-Like HEI-OC1 Cells From Cisplatin-Induced Damage. | 期刊论文 | Li He;Song Yongdong;He Zuhong;Chen Xiaoyun;Wu Xianmin;Li Xiaofei;Bai Xiaohui;Liu Wenwen;Li Boqin;Wang Shanshan;Han Yuechen;Xu Lei;Zhang Daogong;Li Jianfeng;Chai Renjie;Wang Haibo;Fan Zhaomin |
| 15 | Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea. | 期刊论文 | Waqas Muhammad;Guo Luo;Zhang Shasha;Chen Yan;Zhang Xiaoli;Wang Lei;Tang Mingliang;Shi Haibo;Bird Phillip I;Li Huawei;Chai Renjie |
| 16 | Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea. | 期刊论文 | Cheng Cheng;Guo Luo;Lu Ling;Xu Xiaochen;Zhang ShaSha;Gao Junyan;Waqas Muhammad;Zhu Chengwen;Chen Yan;Zhang Xiaoli;Xuan Chuanying;Gao Xia;Tang Mingliang;Chen Fangyi;Shi Haibo;Li Huawei;Chai Renjie |
| 17 | Extensive Supporting Cell Proliferation and Mitotic Hair Cell Generation by In Vivo Genetic Reprogramming in the Neonatal Mouse Cochlea. | 期刊论文 | Ni Wenli;Lin Chen;Guo Luo;Wu Jingfang;Chen Yan;Chai Renjie;Li Wenyan;Li Huawei |
| 18 | A Three-Dimensional Culture System with Matrigel Promotes Purified Spiral Ganglion Neuron Survival and Function In Vitro | 期刊论文 | Yan Wenqing;Liu Wenwen;Fan Zhaomin;Sun Gaoying;Han Yuechen;Zhang Daogong;Xu Lei;Wang Mingming;Li Jianfeng;Yan Wenqing;Liu Wenwen;Fan Zhaomin;Sun Gaoying;Han Yuechen;Zhang Daogong;Xu Lei;Qi Jieyu;Fang Qiaojun;Liu Dong;Chai Renjie;Wang Haibo |
| 19 | Characterization of Lgr5+ Progenitor Cell Transcriptomes after Neomycin Injury in the Neonatal Mouse Cochlea. | 期刊论文 | Zhang Shasha;Zhang Yuan;Yu Pengfei;Hu Yao;Zhou Han;Guo Lingna;Xu Xiaochen;Zhu Xiaocheng;Waqas Muhammad;Qi Jieyu;Zhang Xiaoli;Liu Yan;Chen Fangyi;Tang Mingliang;Qian Xiaoyun;Shi Haibo;Gao Xia;Chai Renjie |
| 20 | Reduced TRMU expression increases the sensitivity of hair-cell-like HEI-OC-1 cells to neomycin damage in vitro. | 期刊论文 | He Zuhong;Sun Shan;Waqas Muhammad;Zhang Xiaoli;Qian Fuping;Cheng Cheng;Zhang Mingshu;Zhang Shasha;Wang Yongming;Tang Mingliang;Li Huawei;Chai Renjie |
| 21 | 人工听觉技术概要 | 专著 | 柴人杰;陈峰;陈杰;戴艳红;高下;陆玲;麻晓峰;王俊国;钱晓云;杨烨;俞晨杰 |
| 22 | Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea. | 期刊论文 | Zhang Yanping;Guo Luo;Lu Xiaoling;Cheng Cheng;Sun Shan;Li Wen;Zhao Liping;Lai Chuijin;Zhang Shasha;Yu Chenjie;Tang Mingliang;Chen Yan;Chai Renjie;Li Huawei |
| 23 | Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea. | 期刊论文 | Ni Wenli;Zeng Shan;Li Wenyan;Chen Yan;Zhang Shasha;Tang Mingliang;Sun Shan;Chai Renjie;Li Huawei |
| 24 | Bmi1 regulatesauditory hair cell survival by maintaining redox balance. | 期刊论文 | Chen yan;Li linhui;Ni Wenli;Zhang Yanping;Sun Shan;Miao D;Chai Renjie;Li Huawei |
| 25 | Bone morphogenetic protein 4 promotes the survival and preserves the structure of flow-sorted Bhlhb5+ cochlear spiral ganglion neurons in vitro. | 期刊论文 | Waqas Muhammad;Sun Shan;Xuan Chuanyin;Fang Qiaojun;Zhang Xiaoli;Islam Irum-Us;Qi Jieyu;Zhang Shasha;Gao Xia;Tang Mingliang;Shi Haibo;Li Huawei;Chai Renjie |
| 26 | Inhibition of ARC decreases the survival of HEI-OC-1 cells after neomycin damage in vitro. | 期刊论文 | Guan Ming;Fang Qiaojun;He Zuhong;Li Yong;Qian Fuping;Qian Xiaoyun;Lu Ling;Zhang Xiaoli;Liu Dingding;Qi Jieyu;Zhang Shasha;Tang Mingliang;Gao Xia;Chai Renjie |
| 27 | Characterization of Wnt and Notch-Responsive Lgr5+ Hair Cell Progenitors in the Striolar Region of the Neonatal Mouse Utricle. | 期刊论文 | You Dan;Guo Luo;Li Wenyan;Sun Shan;Chen Yan;Chai Renjie;Li Huawei |
| 28 | Autophagy protects auditory hair cells against neomycin-induced damage. | 期刊论文 | He Zuhong;Guo Lingna;Shu Yilai;Fang Qiaojun;Zhou Han;Liu Yongze;Liu Dingding;Lu Ling;Zhang Xiaoli;Ding Xiaoqiong;Liu Dong;Tang Mingliang;Kong Weijia;Sha Suhua;Li Huawei;Gao Xia;Chai Renjie |
| 29 | Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. | 期刊论文 | Li Wenyan;Wu Jingfang;Yang Jianming;Sun Shan;Chai Renjie;Chen Zheng-Yi;Li Huawei |
| 30 | The Three-Dimensional Culture System with Matrigel and Neurotrophic Factors Preserves the Structure and Function of Spiral Ganglion Neuron In Vitro. | 期刊论文 | Sun Gaoying;Liu Wenwen;Fan Zhaomin;Zhang Daogong;Han Yuechen;Xu Lei;Qi Jieyu;Zhang Shasha;Gao Bradley T;Bai Xiaohui;Li Jianfeng;Chai Renjie;Wang Haibo |
| 31 | Novel compounds protect auditory hair cells against gentamycin-induced apoptosis by maintaining the expression level of H3K4me2 | 期刊论文 | Li Ao;You Dan;Li Wenyan;Cui Yingjie;He Yingzi;Li Wen;Chen Yan;Feng Xiao;Sun Shan;Chai Renjie;Li Huawei |
| 32 | MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis. | 期刊论文 | Wang Xin;Ling Chang Chun;Li Liping;Qin Yinyin;Qi Jialing;Liu Xiaoyu;You Bo;Shi Yunwei;Zhang Jie;Jiang Qiu;Xu Hui;Sun Cheng;You Yiwen;Chai Renjie;Liu Dong |
| 33 | Bmi1 Regulates the Proliferation of Cochlear Supporting Cells Via the Canonical Wnt Signaling Pathway. | 期刊论文 | Lu Xiaoling;Sun Shan;Qi Jieyu;Li Wenyan;Liu Liman;Zhang Yanping;Chen Yan;Zhang Shasha;Wang Lei;Miao Dengshun;Chai Renjie;Li Huawei |
| 34 | In vivo overexpression of X-linked inhibitor of apoptosis protein protects against neomycin-induced hair cell loss in the apical turn of the cochlea during the ototoxic-sensitive period. | 期刊论文 | Sun Shan;Sun Mingzhi;Zhang Yanping;Cheng Cheng;Waqas Muhammad;Yu Huiqian;He Yingzi;Xu Bo;Wang Lei;Wang Jian;Yin Shankai;Chai Renjie;Li Huawei |
| 35 | Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice. | 期刊论文 | Wang Yanfei;Li Jie;Yao Xuerui;Li Wei;Du Haibo;Tang Mingliang;Xiong Wei;Chai Renjie;Xu Zhigang |
| 36 | Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea. | 期刊论文 | Waqas Muhammad;Zhang Shasha;He Zuhong;Tang Mingliang;Chai Renjie |
| 37 | Wnt Signaling Activates TP53-Induced Glycolysis and Apoptosis Regulator and Protects Against Cisplatin-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea. | 期刊论文 | Liu Wenwen;Xu Xiaochen;Fan Zhaomin;Sun Gaoying;Han Yuechen;Zhang Daogong;Xu Lei;Wang Mingming;Wang Xue;Zhang Shasha;Tang Mingliang;Li Jianfeng;Chai Renjie;Wang Haibo |
| 38 | Damage-Recruited Lgr5+ Cells Regenerate Hair Cells viaProliferation and Direct Transdifferentiationin Neonatal Mouse Utricle | 期刊论文 | Wang Tian;Chai Renjie;Kim Grace;Pham Nicole;Jansson Lina;Nguyen Duc-Huy;Kuo Bryan;May Lindsey;Zuo Jian;Cunningham Lisa;Cheng Alan |
| 39 | Histone deacetylase 1 is required for the development of the zebrafish inner ear. | 期刊论文 | He Yingzi;Tang Dongmei;Li Wenyan;Chai Renjie;Li Huawei |
| 40 | Insm1a Regulates Motor Neuron Development in Zebrafish. | 期刊论文 | Gong Jie;Wang Xin;Zhu Chenwen;Dong Xiaohua;Zhang Qinxin;Wang Xiaoning;Duan Xuchu;Qian Fuping;Shi Yunwei;Gao Yu;Zhao Qingshun;Chai Renjie;Liu Dong |
| 41 | Spatiotemporal expression of Ezh2 in the developing mouse cochlear sensory epithelium. | 期刊论文 | Chen Yan;Li Wenyan;Li Wen;Chai Renjie;Li Huawei |
| 42 | Reduced mtDNA copy number increases the sensitivity of tumor cells to chemotherapeutic drugs. | 期刊论文 | Mei Honglin;Sun Shan;Bai Yan;Chen Yan;Chai Renjie;Li Huawei |
| 43 | Auditory Neuropathy after Damage to Cochlear Spiral Ganglion Neurons in Mice Resulting from Conditional Expression of Diphtheria Toxin Receptors. | 期刊论文 | Pan Haolai;Song Qiang;Huang Yanyan;Wang Jiping;Chai Renjie;Yin Shankai;Wang Jian |
| 44 | The Three-Dimensional Culture System with Matrigel and Neurotrophic Factors Preserves the Structure and Function of Spiral Ganglion Neuron In Vitro. | 期刊论文 | Sun Gaoying;Liu Wenwen;Fan Zhaomin;Zhang Daogong;Han Yuechen;Xu Lei;Qi Jieyu;Zhang Shasha;Gao Bradley T;Bai Xiaohui;Li Jianfeng;Chai Renjie;Wang Haibo |
| 45 | Bmi1 Regulates the Proliferation of Cochlear Supporting Cells Via the Canonical Wnt Signaling Pathway. | 期刊论文 | Lu Xiaoling;Sun Shan;Qi Jieyu;Li Wenyan;Liu Liman;Zhang Yanping;Chen Yan;Zhang Shasha;Wang Lei;Miao Dengshun;Chai Renjie;Li Huawei |
| 46 | Loss of CIB2 Causes Profound Hearing Loss and Abolishes Mechanoelectrical Transduction in Mice. | 期刊论文 | Wang Yanfei;Li Jie;Yao Xuerui;Li Wei;Du Haibo;Tang Mingliang;Xiong Wei;Chai Renjie;Xu Zhigang |
| 47 | Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea. | 期刊论文 | Waqas Muhammad;Zhang Shasha;He Zuhong;Tang Mingliang;Chai Renjie |
| 48 | Wnt Signaling Activates TP53-Induced Glycolysis and Apoptosis Regulator and Protects Against Cisplatin-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea. | 期刊论文 | Liu Wenwen;Xu Xiaochen;Fan Zhaomin;Sun Gaoying;Han Yuechen;Zhang Daogong;Xu Lei;Wang Mingming;Wang Xue;Zhang Shasha;Tang Mingliang;Li Jianfeng;Chai Renjie;Wang Haibo |
| 49 | Insm1a Regulates Motor Neuron Development in Zebrafish. | 期刊论文 | Gong Jie;Wang Xin;Zhu Chenwen;Dong Xiaohua;Zhang Qinxin;Wang Xiaoning;Duan Xuchu;Qian Fuping;Shi Yunwei;Gao Yu;Zhao Qingshun;Chai Renjie;Liu Dong |
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