【81170792】微炎症状态下mTOR通路激活致SREBP-2活化异常：脂代谢紊乱介导靶器官损害进展的潜在新机制国家自然基金项目

微炎症状态下mTOR通路激活致SREBP-2活化异常：脂代谢紊乱介导靶器官损害进展的潜在新机制

项目批准号： 81170792

批准年份： 2011

学科分类： H0710.脂质代谢异常

项目负责人：马坤岭

资助类别：面上项目

负责人职称：教授

依托单位：东南大学

资助金额： 51万元

关键词：细胞胆固醇稳态;炎症;雷帕霉素靶蛋白;脂代谢紊乱

起止时间： 2012-01-01到2015-12-31

中英文摘要
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序号	标题	类型	作者
1	Inflammatory stress induces lipid accumulation in multi-organs of db/db mice.	期刊论文	Wu Y\|Hu ZB\|Liu L\|Liu BC.\|
2	Cholesterol loading activates intracellular renin-angiotensin system in human renal mesangial cells: a potential mechanism for glomerulosclerosis.	会议论文
3	糖尿病早期动脉粥样硬化新机制：血小板微粒导致主动脉内皮损伤（壁报）	会议论文
4	mTOR在炎症诱导载脂蛋白E基因敲除小鼠动脉粥样硬化进展中的作用研究	会议论文
5	Elevatedserum platelet microparticles contribute to aorta endothelial injury: apotential new mechanism for atherosclerosis in diabetes	会议论文
6	肾脏局部肾素血管紧张素系统激活在载脂蛋白E基因敲除小鼠脂质肾损伤中的作用	期刊论文	黄文瑾\|陈珑\|黄海泉\|刘必成\|
7	Establishment Of a Novel Inflamed Animal Model Of Diabetic Nephropathy.	会议论文
8	肾脏局部肾素血管紧张素系统激活在载脂蛋白E基因敲除小鼠脂质肾损伤中的作用	期刊论文	黄文瑾\|陈珑\|黄海泉\|刘必成\|
9	Activation of mTOR Modulates SREBP-2 to Induce Foam Cell Formation in vascular smooth Muscle Cells through Increased retinoblastoma Protein Phosphorylation.	会议论文
10	低密度脂蛋白受体表达失调在炎性反应介导的糖尿病肾病足细胞损伤中的作用	期刊论文	吴娱\|胡泽波\|吕林莉\|刘必成\|
11	血小板微粒活化促进糖尿病肾病肾小球内皮细胞损伤（壁报）	会议论文
12	Activation of CXCL16/CXCR6 pathway by inflammation accelerates the progression of diabetic nephropathy(Poster)	会议论文
13	糖尿病肾病微炎症模型的建立及意义	会议论文
14	脂质刺激在肾小管上皮细胞胞内肾素-血管紧张素系统活化中的作用及可能机制	会议论文
15	Dyslipidemia activates intracellular renin-angiotensin system and accelerates the progression of renal tubular interstitial fibrosis.	会议论文
16	Increased serum platelet microparticle contributesto glomerular endothelial injury in diabeticnephropathy.	会议论文
17	炎症诱导低密度脂蛋白受体表达失调在终末期肾病患者桡动脉泡沫细胞形成中的作用	期刊论文	黄海泉\|陈珑\|王艳丽\|刘必成\|
18	Activation of CXCL16/CXCR6 pathway by inflammation accelerates the progression of diabetic nephropathy(Poster)	会议论文
19	Activation of mTOR Modulates LDL receptor at transcriptional and Post-Transcriptional Level to Accelerate Lipid Accumulationin Fatty Livers of Apolipoprotein E Knockout Mice.	会议论文
20	Activation of mTOR contributes to foam cell formation in the radial arteries of patients with end-stage renal disease.	期刊论文	Zhang Y\|Liu H\|Wang YL\|Liu BC\|
21	Inflammation Disrupts the LDL Receptor Pathway and Accelerates the Progression of Vascular Calcification in ESRD Patients	期刊论文	Zhang XL\|Liu H\|Wang YL\|Liu BC\|
22	微炎症致脂质稳态失调在小鼠心肌纤维化中的作用	期刊论文	张洋\|倪海峰\|吕林莉\|刘必成\|
23	Interaction of RAS Activation and Lipid Disorders Accelerates the Progression of Glomerulosclerosis .	期刊论文	Wu Y\|Lv LL\|Ruan XZ\|Liu BC\|
24	Dysregulation of low-density lipoprotein receptor contributes to podocyte injuries in diabetic nephropathy.	期刊论文	Wu Y\|Hu ZB\|Liu L\|Liu BC.\|
25	Inflammation stress Induces Lipid redistribution in db/db Mice via the Disruption of LDL receptor Pathway.	会议论文
26	慢性炎性反应对糖尿病肾病的促进作用	期刊论文	吴娱\|陈珑\|吕林莉\|刘必成\|
27	Activation of mTOR Modulates LDL receptor at transcriptional and Post-Transcriptional Level to Accelerate Lipid Accumulation in Fatty Livers of Apolipoprotein E Knockout Mice.	会议论文
28	微炎症介导的CXCL16/CXCR6途径激活在糖尿病肾病中的作用研究（壁报）	会议论文
29	血管紧张素Ⅱ通过干扰低密度脂蛋白受体途径促进肾小管上皮细胞内脂质沉积	期刊论文	王长娴\|刘晶\|张洋\|刘必成\|
30	Inflammatory Stress Exacerbates the Progression of Cardiac Fibrosis in High-Fat-Fed Apolipoprotein E Knockout Mice via Endothelial-Mesenchymal Transition	期刊论文	Tang, Ri Ning\|Ni, Hai Feng\|Ruan, Xiong Zhong\|Liu, Bi Cheng\|
31	Angiotensin II induces lipid accumulation in hepatic cells via the disruption of low density lipoprotein receptor pathway.	会议论文
32	炎症致低密度脂蛋白受体表达失调在糖尿病肾病足细胞损伤中的作用研究	会议论文
33	Activation of mTORC1 disrupted LDL receptor pathway: A potential new mechanism for the progression of non-alcoholic fatty liver disease.	期刊论文	Tang, Ri Ning\|Liu, Hong\|Ruan, Xiong Zhong\|Liu, Bi Cheng\|
34	Analysis of the spectrum and antibiotic resistance of uropathogens in vitro: Results based on a retrospective study from a tertiary hospital	期刊论文	Ma, Kun Ling\|Wang, Chang Xian\|
35	细胞胆固醇稳态失衡在非酒精性脂肪性肝病中的作用研究进展	期刊论文	吴娱\|马坤岭\|
36	Activation of CXCL16/CXCR6 pathway by inflammation accelerates the progression of atherosclerosis in ESRD patients(Poster)	会议论文
37	Activation of the renin-angiotensin system is involved in hyperlipidemia- mediated liver injuries in Apolipoprotein knockout mice and HepG2 cells.	会议论文
38	CXCL16/CXCR6途径激活促进终末期肾病动脉粥样硬化进展（壁报）	会议论文
39	THE ACTIVATION OF MTOR PATHWAY INDUCED BY INFLAMMATION ACCELERATES THE PROGRESSION OF ATHEROSCLEROSIS IN HEMODIALYSIS PATIENTS	会议论文
40	Increased serum platelet microparticle contributes to glomerular endothelial injury in diabetic nephropathy(Oral Presentation)	会议论文
41	Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation	期刊论文	Wu Y\|Lv LL\|Ruan XZ\|Liu BC\|
42	血管紧张素Ⅱ灌注在脂质肝损伤中的作用研究	期刊论文	刘亮\|王桂花\|鲁荐\|马坤岭\|
43	Activation of renin-angiotensin system is involved in dyslipidemia-mediated renal injuries in apolipoprotein E knockout mice and HK-2 cells	期刊论文	Ni, Hai-Feng\|Chen, Ya-Xi\|Ruan, Xiong-Zhong\|Liu, Bi-Cheng\|
44	The dysregulation of LDL receptor pathway induced by inflammation contributes to podocyte injury in diabetic nephropathy.	会议论文
45	亚细胞器在胆固醇代谢紊乱中的作用	期刊论文	胡泽波\|马坤岭\|
46	PCSK9在脂代谢调节中的作用研究进展	期刊论文	张洋\|马坤岭\|
47	Activation of mTOR Pathway Induced by Inflammation Accelerates the Progression of Atherosclerosis in Apolipoprotein E Knockout Mice.	会议论文
48	Establishment of an Inflamed Animal Model of Diabetic Nephropathy	期刊论文	Wu, Yu\|Hu, Ze Bo\|Ruan, Xiong Zhong\|Liu, Bi Cheng\|
49	Inflammatory stress exacerbates lipid accumulation and podocyte injuries in diabetic nephropathy.	期刊论文	Liu L\|Lu J\|Zhang XL\|Liu BC.\|
50	炎症激活足细胞HIPK2信号加速糖尿病肾病进展	会议论文
51	Increased mTORC1 activity contributes to atherosclerosis in apolipoprotein E knockout mice and in vascular smooth muscle cells .	期刊论文	Ma KL\|
52	肾素-血管紧张素系统在非酒精性脂肪性肝病发病机制中的作用研究进展	期刊论文	吴娱\|马坤岭\|
53	Activation of mTOR Pathway Induced by Inflammation Accelerates the Progression of Atherosclerosis in Apolipoprotein E Knockout Mice.	会议论文

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