智能响应成像型分子靶向/基因治疗联用纳米给药系统一体化诊疗EGFR突变型肺癌研究

81571802
2015
H2808.纳米医学
高瑜
面上项目
教授
福州大学
58万元
近红外荧光成像;基因载体;联合治疗;肿瘤靶向治疗;EGFR突变型肺癌
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 EpCAM aptamer-functionalized mesoporous silica nanoparticles for efficient colon cancer cell-targeted drug delivery. 期刊论文 Xie Xiaodong;Li Fengqiao;Zhang Huijuan;Lu Yusheng;Lian Shu;Lin Hang;Gao Yu;Jia Lee
2 Role of generation on folic acid-modified poly(amidoamine) dendrimers for targeted delivery of baicalin to cancer cells. 期刊论文 Lv Tingting;Yu Tingting;Fang Yunpeng;Zhang Suyan;Jiang Minghong;Zhang Huijuan;Zhang Yingying;Li Ziying;Chen Haijun;Gao Yu
3 一种米非司酮壳聚糖缓释微球制剂及其制备方法 专利 高瑜;吴福强;李雅珍;王超群;陈海军
4 一种兼具分子靶向及可控光动力治疗的纳米诊疗剂及其制备方法和用途 专利 高瑜;张英英;柯玲洁;林晓文;张露;李冬梅;方胤瑾;雷桂财;陈海军
5 The nanotechnology race between China and the United States. 期刊论文 Dong Haiyan;Gao Yu;Sinko Patrick;Wu Zaisheng;Xu Jianguo;Jia Lee
6 Development of chitosan-based nanoparticles for improving anti-cancer effects and bioavailability of mifepristone 期刊论文 Huijuan Zhang;Fuqiang Wu;Yazhen Li;Xiping Yang;Jiamei Huang;Tingting Lv;Yingying Zhang;Jianzhong Chen;Haijun Chen;Yu Gao;Guannan Liu;Lee Jia
7 Eliminating blood oncogenic exosomes via the small intestine with aptamer-functionalized nanoparticles 期刊论文 Xiaodong Xie;Huifang Nie;Yu Zhou;Shu Lian;Hao Mei;Yusheng Lu;Haiyan Dong;Fengqiao Li;Tao Li;Bifei Li;Jie Wang;Min Lin;Chaihung Wang;Jingwei Shao;Yu Gao;Jianming Chen;Fangwei Xie;Lee Jia
8 一种用于肺癌治疗的壳聚糖纳米材料及其制备方法 专利 高瑜;李子颖;朱立胜;叶金祥;陈海军
9 一种肺癌靶向自组装纳米粒的制备方法 专利 高瑜;李章翠;张英英;王秀英;文一博;张涛;陈海军
10 一种适配体修饰的携氧载药多功能脂质体复合物 专利 高瑜;黎凤乔;梅淏;解晓东;贾力
11 Erlotinib-guided self-assembled trifunctional click nanotheranostics for distinguishing druggable mutations and synergistic therapy of nonsmall cell lung cancer 期刊论文 Yu Gao;Huijuan Zhang;Yingying Zhang;Tingting Lv;Lu Zhang;Ziying Li;Xiaodong Xie;Fengqiao Li;Haijun Chen;Lee Jia
12 一种用于可控光动力治疗的纳米药物及其制备方法 专利 高瑜;李子颖;吕婷婷;王秀英;阙榕槟;马士杰;陈海军
13 Folate and heptamethine cyanine modified chitosan-based nanotheranostics for tumor targeted near infrared fluorescence imaging and photodynamic therapy 期刊论文 Zhang Yingying;Lv Tingting;Zhang Huijuan;Xie Xiaodong;Li Ziying;Chen Haijun;Gao Yu
14 兼具分子靶向/基因/光热治疗的纳米复合物的制备方法 专利 高瑜;李子颖;朱立胜;李旭东;张露;徐靓;陈海军
15 Synthesis and potent cytotoxic activity of diosgenin derivative FZU-0021-194-P2 and its phytosomes against non-small-cell lung cancer cells 期刊论文 Liang Xu;Dekang Xu;Ziying Li;Yu Gao;Haijun Chen
16 Translation of combination nanodrugs into nanomedicines: lessons learned and future outlook 期刊论文 Qingxin Mu;Jesse Yu;Lisa A.McConnachie;John C. Kraft;Yu Gao;Gaurav K. Gulati;Rodney J.Y. Ho
17 Biomimetic oxidative coupling cyclization enabling rapid construction of isochromanoindolenines 期刊论文 Jingxiang Ye;Yuqi Lin;Qing Liu;Dekang Xu;Fan Wu;Bin Liu;Yu Gao;Haijun Chen
18 Recent developments of nanotherapeutics for targeted and long-acting, combination HIV chemotherapy 期刊论文 Yu Gao;John C. Kraft;Danni Yu;Rodney J.Y.Ho
19 一种具有肿瘤靶向性的厄洛替尼-Cy7-壳聚糖聚合物 专利 高瑜;张慧娟;张英英;陈海军;贾力
20 CXCR7 is not obligatory for CXCL12-CXCR4-induced epithelial-mesenchymal transition in human ovarian cancer 期刊论文 Ning Zheng;Weiqun Liu;Jiahang Chen;Bifei Li;Jian Liu;Jichuang Wang;Yu Gao;Jingwei Shao;Lee Jia
21 Chloroquine in combination with aptamer-modified nanocomplexes for tumor vessel normalization and efficient erlotinib/Survivin shRNA co-delivery to overcome drug resistance in EGFR-mutated non-small cell lung cancer 期刊论文 Tingting Lv;Ziying Li;Liang Xu;Yingying Zhang;Haijun Chen;Yu Gao
22 Construction and biological evaluation of different self-assembled nanoarchitectures of FZU-03,010 期刊论文 Tingting Lv;Liang Xu;Guolin Wu;Cailong Li;Yibo Wen;Tao Zhang;Yu Gao;Haijun Chen
23 The novel nanomissile targeting two biomarkers and accurately bombing CTCs with doxorubicin. 期刊论文 Gao Yu;Xie Xiaodong;Li Fengqiao;Lu Yusheng;Li Tao;Lian Shu;Zhang Yingying;Zhang Huijuan;Mei Hao;Jia Lee
24 Discovery of novel negletein derivatives as potent anticancer agents for acute myeloid leukemia. 期刊论文 Wu Jianlei;Chen Yingyu;Liu Xuanping;Gao Yu;Hu Jianda;Chen Haijun
25 一种抗体偶联的介孔二氧化硅/米非司酮纳米制剂 专利 高瑜;贾力;顾颂恩
26 Aptamer-conjugated chitosan anchored liposomal complexes for targeted delivery of erlotinib to EGFR-mutated lung cancer cells. 期刊论文 Li Fengqiao;Mei Hao;Xie Xiaodong;Zhan Huijuan;Liu Jian;Lv Tingting;Nie Huifang;Gao Yu;Jia Lee
27 Dual-responsive nanosystem for precise molecular subtyping and resistant reversal of EGFR targeted therapy 期刊论文 Yingying Zhang;Lu Zhang;Xiaowen Lin;Lingjie Ke;Bifei Li;Liang Xu;Tingting Lv;Ziying Li;Haijun Chen;Yu Gao
28 Comparisons between graphene oxide and graphdiyne oxide in physicochemistry biology and cytotoxicity 期刊论文 Tingting Zheng;Yu Gao;Xiaoxiao Deng;Huibiao Liu;Jian Liu;Ran Liu;Jingwei Shao;Yuliang Li;Lee Jia
29 A hematoporphyrin and indocyanine green co-delivery system with NIR triggered-controllable photoactivities for photodynamic therapy. 期刊论文 Li Ziying;Lv Tingting;Zhang Yingying;Xu Liang;Zhang Lu;Wang Xiuying;Chen Haijun;Gao Yu
30 The architecture and function of monoclonal antibody-functionalized mesoporous silica nanoparticles loaded with mifepristone: repurposing abortifacient for cancer metastatic chemoprevention. 期刊论文 Gao Yu;Gu Songen;Zhang Yingying;Xie Xiaodong;Yu Ting;Lu Yusheng;Zhu Yewei;Chen Wenge;Zhang Huijuan;Dong Haiyan;Sinko Patrick J.;Jia Lee
31 Indocyanine green-encapsulated erlotinib modified chitosan nanoparticles for targeted chemo-photodynamic therapy of lung cancer cells 期刊论文 Lu Zhang;Jun Wang;Yingying Zhang;Linjie Ke;Xiaowen Lin;Ziying Li;Haijun Chen;Yu Gao
32 Co-delivery of oxygen and erlotinib by aptamer-modified liposomal complexes to reverse hypoxia-induced drug resistance in lung cancer. 期刊论文 Li Fengqiao;Mei Hao;Gao Yu;Xie Xiaodong;Nie Huifang;Li Tao;Zhang Huijuan;Jia Lee
33 In vivo inhibition of circulating tumor cells by two apoptosis promoting circular aptamers with enhanced specificity 期刊论文 Haiyan Dong;Longyu Han;Jie Wang;Jingjing Xie;Yu Gao;Fangwei Xie;Lee Jia
34 具有肿瘤靶向的PAMAM-FA/黄芩苷纳米药物及其制备方法 专利 高瑜;吕婷婷;江铭红;方云鹏;张素燕;陈海军
35 一种具肿瘤靶向性的纳米复合物Apt-PAMAM/ERL/SUV及其制备和应用 专利 高瑜;吕婷婷;文一博;张涛;陈海军
36 一种氯喹和靶向共输送纳米复合物的组合物的应用 专利 高瑜;吕婷婷;李子颖;文一博;张涛;陈海军
37 Challenges and opportunities from basic cancer biology for nanomedicine for targeted drug delivery 期刊论文 Xiaodong Xie;Yingying Zhang;Fengqiao Li;Tingting Lv;Ziying Li;Haijun Chen;Lee Jia;Yu Gao
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