NOX1及mtROS介导的eNOS解偶联在PM2.5致心血管毒性中的作用及机制研究

21876026
2018
B0607.环境毒理与健康
唐萌
面上项目
教授
东南大学
66万元
信号通路;基因表达;细胞凋亡;纳米材料
2019-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Toxic effects and involved molecular pathways of nanoparticles on cells and subcellular organelles 期刊论文 Liu Na;Tang Meng
2 Integrative analysis of mRNAs, miRNAs and lncRNAs in urban particulate matter SRM 1648a-treated EA.hy926 human endothelial cells 期刊论文 Wang Yan;Tang Meng
3 Effect and mechanism of PI3K/AKT/mTOR signaling pathway in the apoptosis of GC-1cells induced by nickel nanoparticles 期刊论文 Yongya Wu;Jun Ma;Yufei Sun;Meng Tang;Lu Kong
4 NADPH oxidases regulate endothelial inflammatory injury induced by PM 2.5 via AKT/eNOS/NO axis 期刊论文 Lingyue Zou;Lilin Xiong;Tianshu Wu;Tingting Wei;Na Liu;Changcun Bai;Xiaoquan Huang;Yuanyuan Hu;Yuying Xue;Ting Zhang;Meng Tang
5 The glycolytic shift was involved in CdTe/ZnS quantum dots inducing microglial activation mediated through the mTOR signaling pathway 期刊论文 Wu Tianshu;He Keyu;Liang Xue;Wei Tingting;Wang Yan;Zou Lingyue;Zhang Ting;Xue Yuying;Tang Meng
6 Biodistribution and organ oxidative damage following 28 days oral administration of nanosilver with/without coating in mice 期刊论文 Gan Junying;Sun Jindu;Chang Xiaoru;Li Wenhua;Li Jiangyan;Niu Shuyan;Kong Lu;Zhang Ting;Wu Tianshu;Tang Meng;Xue Yuying
7 Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia 期刊论文 Tianshu Wu;Xue Liang;Xi Liu;Yimeng Li;Yutong Wang;Lu Kong;Meng Tang
8 In vitro review of nanoparticles attacking macrophages: Interaction and cell death 期刊论文 Yiru Niu;Meng Tang
9 Identification of mRNA-miRNA crosstalk in human endothelial cells after exposure of PM2.5 through integrative transcriptome analysis 期刊论文 Wang Yan;Zou Lingyue;Wu Tianshu;Xiong Lilin;Zhang Ting;Kong Lu;Xue Yuying;Tang Meng
10 Molecular mechanisms underlying nickel nanoparticle induced rat Sertoli-germ cells apoptosis 期刊论文 Kong Lu;Hu Wangcheng;Gao Xiaojie;Wu Yongya;Xue Yuying;Cheng Keping;Tang Meng
11 Mitophagy-lysosomal pathway is involved in silver nanoparticle-induced apoptosis in A549 cells. 期刊论文 Jiangyan Li;Xiaoru Chang;Mengting Shang;Shuyan Niu;Wenli Zhang;Bangyong Zhang;Wenyan Huang;Tianshu Wu;Ting Zhang;Meng Tang;Yuying Xue
12 CdTe quantum dots trigger oxidative stress and endoplasmic reticulum stress‐induced apoptosis and autophagy in rat Schwann cell line RSC96 期刊论文 Changcun Bai;Yongshuai Yao;Zhihui Wang;Xiaoquan Huang;Tingting Wei;Lingyue Zou;Na Liu;Ting Zhang;Meng Tang
13 The apoptosis induced by CdTe quantum dots through the mitochondrial pathway in dorsal root ganglion cell line ND7/23 期刊论文 Changcun Bai;Tingting Wei;Lingyue Zou;Na Liu;Xiaoquan Huang;Meng Tang
14 Genome-wide identification and functional analysis of long non-coding RNAs in human endothelial cell line after incubation with PM2.5 期刊论文 Wang Yan;Wu Tianshu;Zou Lingyue;Xiong Lilin;Zhang Ting;Kong Lu;Xue Yuying;Tang Meng
15 The key role of autophagy in silver nanoparticle-induced BV2 cells inflammation and polarization 期刊论文 Mengting Shang;Xiaoru Chang;Shuyan Niu;Jiangyan Li;Wenli Zhang;Tianshu Wu;Ting Zhang;Meng Tang;Yuying Xue
16 Urban fine particulate matter causes cardiac hypertrophy through calcium-mediated mitochondrial bioenergetics dysfunction in mice hearts and human cardiomyocytes 期刊论文 Lingyue Zou;Binjing Li;Lilin Xiong;Yan Wang;Wenjing Xie;Xiaoquan Huang;Ying Liang;Tingting Wei;Na Liu;Xiaoru Chang;Changcun Bai;Tianshu Wu;Yuying Xue;Ting Zhang;Meng Tang
17 PM2.5 induces autophagy and apoptosis through endoplasmic reticulum stress in human endothelial cells 期刊论文 Yan Wang;Meng Tang
18 Mesoporous Silica Nanoparticles at Predicted Environmentally Relevant Concentrations Cause Impairments in GABAergic Motor Neurons of Nematode Caenorhabditis elegans 期刊论文 Xue Liang;Yutong Wang;Jin Cheng;Qianqian Ji;Yan Wang;Tianshu Wu;Meng Tang
19 Silver nanoparticle-induced impaired autophagic flux and lysosomal dysfunction contribute to the microglia inflammation polarization 期刊论文 Mengting Shang;Shuyan Niu;Xiaoru Chang;Jiangyan Li;Wenli Zhang;Menghao Guo;Tianshu Wu;Ting Zhang;Meng Tang;Yuying Xue
20 The role of ferroptosis mediated by NRF2/ERK-regulated ferritinophagy in CdTe QDs-induced inflammation in macrophage 期刊论文 Na Liu;Ying Liang;Tingting Wei;Lingyue Zou;Xiaoquan Huang;Lu Kong;Meng Tang;Ting Zhang
21 Ambient particulate matter triggers dysfunction of subcellular structures and endothelial cell apoptosis through disruption of redox equilibrium and calcium homeostasis 期刊论文 Wang Yan;Wu Tianshu;Tang Meng
22 The crosstalk between DRP1-dependent mitochondrial fission and oxidative stress triggers hepatocyte apoptosis induced by silver nanoparticles 期刊论文 Li Jiangyan;Chang Xiaoru;Shang Mengting;Niu Shuyan;Zhang Wenli;Li Yunjing;Sun Zuoyi;Wu Tianshu;Kong Lu;Zhang Ting;Tang Meng;Xue Yuying
23 The cytotoxicity of core-shell or non-shell structure quantum dots and reflection on environmental friendly: A review 期刊论文 Zhihui Wang;Meng Tang
24 Differentially expressed profiles of long non-coding RNA in responses to graphene quantum dots in microglia through analysis of microarray data 期刊论文 Tianshu Wu;Xue Liang;Yimeng Li;Xi Liu;Meng Tang
25 Review of gut nanotoxicology in mammals: Exposure, transformation, distribution and toxicity 期刊论文 Xiaoquan Huang;Meng Tang
26 CdTe and CdTe@ZnS quantum dots induce IL-1ß-mediated inflammation and pyroptosis in microglia 期刊论文 Xue Liang;Tianshu Wu;Yan Wang;Tingting Wei;Lingyue Zou;Changcun Bai;Na Liu;Ting Zhang;Yuying Xue;Meng Tang
27 A review of pulmonary toxicity of different types of quantum dots in environmental and biological systems 期刊论文 Xiaoli Wang;Keyu He;Yuanyuan Hu;Meng Tang
28 PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance 期刊论文 Wang Yan;Tang Meng
29 The role of NLRP3 inflammasome activation in the neuroinflammatory responses to Ag2Se quantum dots in microglia 期刊论文 Tianshu Wu;Xue Liang;Keyu He;Tingting Wei;Yan Wang;Lingyue Zou;Changcun Bai;Na Liu;Ting Zhang;Yuying Xue;Meng Tang
30 Toxicity of quantum dots on target organs and immune system 期刊论文 Ying Liang;Tao Zhang;Meng Tang
31 A critical review of advances in reproductive toxicity of common nanomaterials to Caenorhabditis elegans and influencing factors 期刊论文 Yongshuai Yao;Ting Zhang;Meng Tang
32 A metabolomics study: CdTe/ZnS quantum dots induce polarization in mice microglia 期刊论文 Keyu He;Xue Liang;Tingting Wei;Na Liu;Yan Wang;Linyue Zou;Changcun Bai;Ying Yao;Tianshu Wu;Lu Kong;Ting Zhang;Yuying Xue;Meng Tang
33 Research progress of nanoparticle toxicity signaling pathway 期刊论文 Li Binjing;Tang Meng
34 Respiratory exposure to graphene quantum dots causes fibrotic effects on lung, liver and kidney of mice 期刊论文 Tianshu Wu;Xinyu Wang;Min Chen;Xiaomeng Zhang;Jixiang Zhang;Jin Cheng;Lu Kong;Meng Tang
35 Tanshinone IIA-regulation of IL-6 antagonizes PM2 .5 -induced proliferation of human bronchial epithelial cells via a STAT3/miR-21 reciprocal loop. 期刊论文 Wenjing Xie;Min Ling;Tian Xiao;Zi Fan;Dongya Chen;Meng Tang;Qian Bian
36 The NLRP3-Mediated Neuroinflammatory Responses to CdTe Quantum Dots and the Protection of ZnS Shell 期刊论文 Tianshu Wu;Xue Liang;Keyu He;Xi Liu;Yimeng Li;Yutong Wang;Lu Kong;Meng Tang
37 The Toxicity Of Metallic Nanoparticles On Liver: The Subcellular Damages, Mechanisms, And Outcomes 期刊论文 Yao Ying;Zang Yiteng;Qu Jing;Tang Meng;Zhang Ting
38 Protein corona mitigated the cytotoxicity of CdTe QDs to macrophages by targeting mitochondria 期刊论文 Na Liu;Ying Liang;Tingting Wei;Lingyue Zou;Changcun Bai;Xiaoquan Huang;Tianshu Wu;Yuying Xue;Meng Tang;Ting Zhang
39 The involvement of DRP1-mediated caspase-1 activation in inflammatory response by urban particulate matter in EA.hy926 human vascular endothelial cells 期刊论文 Yan Wang;Lilin Xiong;Yongshuai Yao;Ying Ma;Qing Liu;Yanting Pang;Meng Tang
40 Identification of potential circRNA-miRNA-mRNA regulatory networks in response to graphene quantum dots in microglia by microarray analysis 期刊论文 Wu Tianshu;Li Yimeng;Liang Xue;Liu Xi;Tang Meng
41 The interaction between nanoparticles-protein corona complex and cells and its toxic effect on cells 期刊论文 Na Liu;Meng Tang;Jiandong Ding
42 Adverse reproductive and developmental consequences of quantum dots 期刊论文 Yao Yongshuai;Chen Zhaofang;Zhang Ting;Tang Meng
43 Toxicological study of metal and metal oxide nanoparticles in zebrafish 期刊论文 Changcun Bai;Meng Tang
44 Atmospheric particulate matter impedes autophagic flux by impairing lysosomal milieu and integrity in human umbilical vein endothelial cells (HUVECs) 期刊论文 Yan Wang;Na Liu;Xiaoquan Huang;Wangcheng Hu;Ying Ma;Ying Liang;Wenjing Xie;Meng Tang
45 Microarray analysis of gene expression differences in microglia after exposure to graphene quantum dots 期刊论文 Liang Xue;Wu Tianshu;Tang Meng
46 Advances in endocrine toxicity of nanomaterials and mechanism in hormone secretion disorders 期刊论文 Yongshuai Yao;Meng Tang
47 Intermittent exposure to airborne particulate matter induces subcellular dysfunction and aortic cell damage in BALB/c mice through multi-endpoint assessment at environmentally relevant concentrations 期刊论文 Yan Wang;Lilin Xiong;Xiaoquan Huang;Ying Ma;Lingyue Zou;Ying Liang;Wenjing Xie;Yongya Wu;Xiaoru Chang;Zhihui Wang;Meng Tang
48 Ambient particulate matter triggers defective autophagy and hijacks endothelial cell renewal through oxidative stress-independent lysosomal impairment 期刊论文 Yan Wang;Ying Ma;Yongshuai Yao;Qing Liu;Yanting Pang;Meng Tang
49 Toxicity mechanism of nanomaterials: Focus on endoplasmic reticulum stress 期刊论文 Binjing Li;Ting Zhang;Meng Tang
50 Urban particulate matter disturbs the equilibrium of mitochondrial dynamics and biogenesis in human vascular endothelial cells 期刊论文 Yan Wang;Lu Kong;Tianshu Wu;Meng Tang
51 Silver nanoparticles modulate mitochondrial dynamics and biogenesis in HepG2 cells 期刊论文 Jiangyan Li;Bangyong Zhang;Xiaoru Chang;Junying Gan;Wenhua Li;Shuyan Niu;Lu Kong;Tianshu Wu;Ting Zhang;Meng Tang;Yuying Xue
52 Research progress on toxicity, function, and mechanism of metal oxide nanoparticles on vascular endothelial cells 期刊论文 Zhihui Wang;Meng Tang
53 Exposure effects of inhaled nickel nanoparticles on the male reproductive system via mitochondria damage 期刊论文 Lu Kong;Jiahui Dong;Wenjuan Lu;Yongya Wu;Lin Liu;Meng Tang
54 Research advance on cell imaging and cytotoxicity of different types of quantum Dots 期刊论文 Xiaoquan Huang;Meng Tang
55 DNA damage in BV-2 cells: An important supplement to the neurotoxicity of CdTe quantum dots 期刊论文 He Keyu;Liang Xue;Wei Tingting;Liu Na;Wang Yan;Zou Linyue;Lu Jie;Yao Ying;Kong Lu;Zhang Ting;Xue Yuying;Wu Tianshu;Tang Meng
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