基于“机体内环境-组织微环境-PI3K/Akt通路”动态调控的“苦参-黄芪”药对治疗肝癌的药效物质和作用机制研究

81973464
2019
H3203.中药药效物质
李清
面上项目
教授
沈阳药科大学
55万元
肝癌;作用机制;药效物质;药对;机体内环境
2020-01-01到2023-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Nanoconfined liquid phase nanoextraction combined with in-fiber derivatization for simultaneous quantification of seventy amino-containing metabolites in plasma by LC-MS/MS: Exploration of lung cancer screening model 期刊论文 Chunyu Yu;Qian Zhang;Liyuan Wang;Yiwen Zhang;Meiyu Cui;Kaishun Bi;Donghao Li;Qing Li
2 A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties. 期刊论文 Yiwen Zhang;Saiyu Li;Panpan Yang;Qian Zhang;Huarong Xu;Kaishun Bi;Qing Li
3 Assessment of Plasma Amino Acids, Purines, Tricarboxylic Acid Cycle Metabolites, and Lipids Levels in NSCLC Patients Based on LC-MS/MS Quantification 期刊论文 Song Cang;Ran Liu;Kunqian Mu;Qi Tang;Haiyue Cui;Kaishun Bi;Yiwen Zhang;Qing Li
4 Accurate Determination for Lipidomics Based on LC-Tandem-MS Parameters Modeling, Prediction, and Database: Monitoring the Progression of Hepatocellular Carcinoma 期刊论文 Qian Zhang;Minghui Tong;Huarong Xu;Yidi Yin;Peng Gao;Kaishun Bi;Yiwen Zhang;Qing Li
5 基于中药复杂体系建立的模式识别整体质量评价方法及其应用 奖励 王铁杰;鲁 艺;李 清;殷 果;王丽君;王淑红;王 珏;王 平;江 坤;刘 然
6 An Integrated Mutually Oriented “Chemical Profiling–Pharmaceutical Effect” Strategy for Screening Discriminating Markers of Underlying Hepatoprotective Effects to Distinguish Garden-Cultivated from Mountain-Cultivated Ginseng 期刊论文 Saiyu Li;Yiwen Zhang;Panpan Yang;Minghui Tong;Luwen Xing;Qian Zhang;Kaishun Bi;Qing Li
7 Across-polarity quantification method for broad metabolome coverage based on consecutive nanoconfined liquid phase nanoextraction technology: Application in discovering the plasma potential biomarkers of different types of cancer 期刊论文 Chunyu Yu;Qian Zhang;Yilin Zou;Ran Liu;Jinhua Zhao;Kaishun Bi;Donghao Li;Qing Li
8 基于药物-机体相互作用的疾病诊断和药物评价 奖励 李清;刘然;张倩;许华容;张译文
9 Nanoconfinement effect based in-fiber extraction and derivatization method for ultrafast analysis of twenty amines in human urine by GC-MS: Application to cancer diagnosis biomarkers’ screening 期刊论文 Chunyu Yu;Liyuan Wang;Jinshi Zheng;Xinran Jiang;Qian Zhang;Yiwen Zhang;Kaishun Bi;Donghao Li;Qing Li
10 Isotope labelled in suit derivatization-extraction integrated system for amine/phenol submetabolome analysis based on nanoconfinement effect: Application to lung cancer 期刊论文 Chunyu Yu;Qian Zhang;Yiwen Zhang;Liyuan Wang;Huarong Xu;Kaishun Bi;Donghao Li;Qing Li
11 一种基于“纤维内衍生化”策略的血浆中70种氨基类物质的定量分析方法及其用途 专利 李清;张倩;毕开顺;于春宇;许华容;张译文
12 一种超快速定量尿液中胺类物质的方法 专利 李清;张倩;毕开顺;于春宇;许华容;张译文
13 A convenient and efficient 4-(diethylamino)-butylamine-labeled polarity-response-homodispersed strategy for absolute quantification of carboxyl submetabolome: Monitoring the whole progressive course of hepatocellular carcinoma 期刊论文 Minghui Tong;Qian Zhang;Yiwen Zhang;Luwen Xing;Kaishun Bi;Qing Li
14 A Dual Coverage Monitoring of the Bile Acids Profile in the Liver–Gut Axis throughout the Whole Inflammation-Cancer Transformation Progressive: Reveal Hepatocellular Carcinoma Pathogenesis 期刊论文 Luwen Xing;Yiwen Zhang;Saiyu Li;Minghui Tong;Kaishun Bi;Qian Zhang;Qing Li
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