基于转基因球虫模型研究禽类保护性免疫应答产生的机制

31330076
2013
C1804.兽医免疫学
索勋
重点项目
教授
中国农业大学
299万元
转基因球虫;禽流感病毒;免疫保护机制;免疫应答的质;交叉递呈
2014-01-01到2018-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Effect of chicken IL-17 and IFN-γ on the immunogenicity of intracellular parasite Eimeria necatrix 会议论文 Duan Chunhui;Zhang Sixin;Tang Xinming;Suo Jingxia;Huang Guangping;Liu Xianyong;Suo Xun
2 ON THE WAY TOWARDS ACTUALIZING RECOMBINANT EIMERIA AS A VACCINE VECTOR 会议论文 Suo Xun;Liu Xianyong;Suo Jingxia;Tang Xinming;Tao Geru;Duan Chunhui;Zhang Sixin;Liao Qin
3 EIMERIA FALCIFORMIS INFECTION PERTURBS THE METABOLIC PATHWAYS IN MICE 会议论文 Huang Guangping;Zhang Sixin;Tang Xiaoli;Liu Xianyong;Suo Xun
4 Transgenic Eimeria magna Perard, 1925 Displays similar Parasitological Properties to the Wild-type strain and induces an exogenous Protein-specific immune response in rabbits (Oryctolagus cuniculus L.) 期刊论文 Tao Geru;Shi Tuanyuan;Tang Xinming;Duszynski Donald W.;Wang Yunzhou;Li Chao;Suo Jingxia;Tian Xiuling;Liu Xianyong;Suo Xun
5 Immunogenicity and protective efficacy of an Eimeria vaccine candidate based on Eimeria tenella immune mapped protein 1 and chicken CD40 ligand 期刊论文 Guangwen Yin;Qian Lin;Jianhan Qiu;Mei Qin;Xinming Tang;Xun Suo;Zhijian Huang;Xianyong Liu
6 Construction of Transgenic Eimeria mitis and Studies of Their Immunogenicity 会议论文 Qin Mei;Tang Xinming;Yin Guangwen;Liu Xianyong;Suo Jingxia;Tao Geru;Suo Xun
7 Molecular analysis of single oocyst of Eimeria by whole genome amplification (WGA) based nested PCR 期刊论文 Wang Yunzhou;Tao Geru;Cui Yujuan;Lv Qiyao;Xie Li;Li Yuan;Suo Xun;Qin Yinghe;Xiao Lihua;Liu Xianyong
8 Chicken IgY Fc expressed by Eimeria mitis enhances the immunogenicity of E-mitis 期刊论文 Qin Mei;Tang Xinming;Yin Guangwen;Liu Xianyong;Suo Jingxia;Tao Geru;El-Ashram Saeed;Li Yuan;Suo Xun
9 Stably Transfected Eimeria as a Vaccine Vector and Beyond 会议论文 Suo Xun;Liu Xianyong;Yin Guangwen;Qin Mei;Huang Xiaoxi;Suo Jingxia;Tang Xinming;Tao Geru;Luo Xue;Li Zhouyang
10 ‘Self-cleaving’ 2A peptide from porcine teschovirus functions in Apicomplexan parasite Eimeria tenella 会议论文 Tang Xinming;Liu Xianyong;Suo Jingxia;Tao Geru;Tian Xiuling;Suo Xun
11 Transgenic Eimeria mitis expressing chicken interleukin 2 stimulated higher cellular immune response in chickens compared with the wild-type parasites 期刊论文 Li Zhuoran;Tang Xinming;Suo Jingxia;Qin Mei;Yin Guangwen;Liu Xianyong;Suo Xun
12 Ethanol and isopropanol trigger rapid egress of intracellular Eimeria tenella sporozoites 期刊论文 Yan Xinlei;Liu Xianyong;Ji Yongsheng;Tao Geru;Suo Xun
13 COMPARATIVE PATHOGENICITY AND CROSS PROTECTION ANALYSES OF TWO DIFFERENT EIMERIA TENELLA ISOLATES FROM CHINA 会议论文 Tang Xiaoli;Liu Xianyong;Suo Xun
14 High pathogenicity and strong immunogenicity of a Chinese isolate of Eimeria magna Perard, 1925 期刊论文 Tao Geru;Wang Yunzhou;Li Chao;Gu Xiaolong;Cui Ping;Fang Sufang;Suo Xun;Liu Xianyong
15 Preparation and identification of monoclonal antibodies against Eimeria tenella surface antigen 13 会议论文 Tang Xinming;Tian Xiuling;Liu Xianyong;Suo Jingxia;Suo Xun
16 An optimized DNA extraction method for molecular identification of coccidian species 期刊论文 Tang Xiaoli;Huang Guangping;Liu Xianyong;El-Ashram Saeed;Tao Geru;Lu Chunxia;Suo Jingxia;Suo Xun
17 转基因球虫共表达多种外源蛋白策略的初步研究 会议论文 汤新明;秦梅;殷光文;索静霞;田秀玲;刘贤勇;索勋
18 Transgenic Eimeria tenella as a vaccine vehicle: expressing TgSAG1 elicits protective immunity against Toxoplasma gondii infections in chickens and mice 期刊论文 Tang Xinming;Yin Guangwen;Qin Mei;Tao Geru;Suo Jingxia;Liu Xianyong;Suo Xun
19 Transfection of Eimeria mitis with Yellow Fluorescent Protein as Reporter and the Endogenous Development of the Transgenic Parasite 期刊论文 Qin Mei;Liu Xian Yong;Tang Xin Ming;Suo Jing Xia;Tao Ge Ru;Suo Xun
20 Development of transgenic Eimeria necatrix expressing hemagglutinin of H9N2 avian influenza virus 会议论文 Duan Chunhui;Hu Dandan;Tang Xinming;Suo Jingxia;Zhang Sixin;Liu Xianyong;Suo Xun
21 和缓艾美耳球虫激发宿主免疫应答的初步研究 期刊论文 汤新明;秦梅;索静霞;田秀玲;刘贤勇;索勋
22 Protective immunity against Eimeria tenella infection in chickens induced by immunization with a recombinant C-terminal derivative of EtIMP1 期刊论文 Yin Guangwen;Lin Qian;Wei Wenjun;Qin Mei;Liu Xianyong;Suo Xun;Huang Zhijian
23 Eimeria tenella infection perturbs the chicken gut microbiota from the onset of oocyst shedding 期刊论文 Huang Guangping;Tang Xiaoli;Bi Feifei;Hao Zhenkai;Han Zhenyan;Suo Jingxia;Zhang Sixin;Wang Si;Duan Chunhui;Yu Zhengquan;Yu Fang;Yu Yonglan;Lv Yanli;Suo Xun;Liu Xianyong
24 一种球虫佐剂及其应用 专利 索勋;刘贤勇;王思;刘晓冬;鲍琳琳;曾欢;秦梅;罗伏兵;王慧强;马志军
25 具备交叉免疫保护力的球虫病疫苗组分及疫苗 专利 索勋;汤新明;刘贤勇;索静霞
26 一种鸡球虫病疫苗免疫方法 专利 索勋;索静霞;汤新明;刘贤勇
27 Calcium-dependent microneme protein discharge and in vitro egress of Eimeria tenella sporozoites 期刊论文 Yan Xinlei;Tao Geru;Liu Xianyong;Ji Yongsheng;Suo Xun
28 The study of immunogenicity of transgenic Eimeria necatrix expressing the interleukin-2-Fc fusion proteins 会议论文 Duan Chunhui;Suo Jingxia;Tang Xinming;Wang Si;Liu Xianyong;Suo Xun
29 Development of a vivo rabbit ligated intestinal Loop Model for HCMV infection 期刊论文 Tang Jin;Wu Qiaoxing;Tang Xinming;Shi Ruihan;Suo Jingxia;Huang Guangping;An Junqing;Wang Jingyuan;Yang Jinling;Hao Wenzhuo;She Ruiping;Suo Xun
30 Recombinant Eimeria acervulina expressing extracellular domain of M2 protein of H9N2 subtype avain influenza virus stimulates immune response and protection in chickens 会议论文 Zhang Sixin;Tang Xinming;Liu Xianyong;Suo Xun
31 Genetic recombination of precociousness and diclazuril-resistance in Eimeria tenella 会议论文 Deng Miner;Hu Dandan;Liu Xianyong;Suo Xun
32 CRISPR-Cas9-mediated genome editing in widespread pathogen Eimeria tenella 会议论文 Tang Xinming;Liu Xianyong;Suo Jingxia;Tian Xiuling;Suo Xun
33 基于IFA技术检测微线体蛋白2在艾美耳属球虫的空间分布 期刊论文 田秀玲;汤新明;秦梅;索静霞;刘贤勇;索勋
34 A cross-protective avian influenza vaccine candidate based on extracellular domain of M2 protein expressed by transgenic Eimeria tenella 会议论文 Tang Xinming;Liu Xianyong;Suo Jingxia;Tao Geru;Tian Xiuling;Zhang Sixin;Suo Xun
35 一种鸡球虫病疫苗及其应用 专利 索勋;汤新明;刘贤勇;索静霞
36 "Self-cleaving" 2A peptide from porcine teschovirus-1 mediates cleavage of dual fluorescent proteins in transgenic Eimeria tenella 期刊论文 Tang Xinming;Liu Xianyong;Tao Geru;Qin Mei;Yin Guangwen;Suo Jingxia;Suo Xun
37 表达鸡IgY分子Fc片段和禽流感病毒抗原的融合基因及其应用 专利 索勋;刘贤勇;秦梅;汤新明;索静霞
38 Cloning and functional verification of U6 promoter of small nuclear RNA (snRNA) from Eimeria tenella 会议论文 Huang Guangping;Liu Xianyong;Shen Bang;Suo Xun
39 艾美耳球虫转基因研究进展 期刊论文 刘贤勇;索勋
40 Influence of Eimeria falciformis Infection on Gut Microbiota and Metabolic Pathways in Mice 期刊论文 Huang Guangping;Zhang Sixin;Zhou Chunxue;Tang Xiaoli;Li Chao;Wang Chaoyue;Tang Xinming;Suo Jingxia;Jia Yonggen;El-Ashram Saeed;Yu Zhengquan;Cai Jianping;Gupta Nishith;Suo Xun;Liu Xianyong
41 A novel vaccine delivery model of a protozoan expressing affinis antigen protects chickens against infection of both species 会议论文 Suo Xun;Tang Xinming;Liu Xianyong;Yin Guangwen;Tao Geru;Zhang Sixin;Suo Jingxia
42 A Novel Vaccine Delivery Model of the Apicomplexan Eimeria tenella Expressing Eimeria maxima Antigen Protects Chickens against Infection of the Two Parasites 期刊论文 Tang Xinming;Liu Xianyong;Yin Guangwen;Suo Jingxia;Tao Geru;Zhang Sixin;Suo Xun
43 Stably Transfected Eimeria as a Vaccine Vector and Beyond 会议论文 Suo Xun;Liu Xianyong;Yin Guangwen;Qin Mei;Huang Xiaoxi;Suo Jingxia;Tang Xinming;Tao Geru;Luo Xue;Li Zhouyang
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