苯溴马隆代谢活化致特异质肝毒性机理研究

81773813
2017
H3510.药物代谢与药物动力学
彭缨
面上项目
教授
沈阳药科大学
54万元
苯溴马隆;反应性代谢产物;特异质肝毒性;代谢活化;蛋白共价结合
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Metabolic Activation of Pirfenidone Mediated by Cytochrome P450s and Sulfotransferases 期刊论文 Zhou Shenzhi;Li Wei;Tian Min;Zhang Na;Yang Xiaojing;Li Weiwei;Peng Ying;Zheng Jiang
2 Glutathione Conjugation and Protein Adduction Derived from Oxidative Debromination of Benzbromarone in Mice 期刊论文 Wang Hui;Wang Wenbao;Gong Bowen;Wang Zedan;Feng Yukun;Zhang Weige;Wang Shaojie;Peng Ying;Zheng Jiang
3 Identification of Ketene-Reactive Intermediate of Erlotinib Possibly Responsible for Inactivation of P450 Enzymes 期刊论文 Zhao Huimin;Li Siyuan;Yang Zixin;Peng Ying;Chen Xiaohui;Zheng Jiang
4 Identification of Quinone Methide Intermediate Resulting from Metabolic Activation of Icaritin in Vitro and in Vivo 期刊论文 Chen Yan;Guo Xiucai;Ma Yufei;Hu Xingjia;Peng Ying;Zheng Jiang
5 Immunochemical Detection of Protein Modification Derived from Metabolic Activation of 8-Epidiosbulbin E Acetate 期刊论文 Zhou Shenzhi;Zhang Na;Hu Zixia;Lin Dongju;Li Weiwei;Peng Ying;Zheng Jiang
6 An LC-MS/MS- and hURAT1 cell-based approach for screening of uricosuric agents 期刊论文 Chen Sun;Mingyu Zhang;Yanhong Zhao;Jianxin Pang;Ying Peng;Jiang Zheng
7 Metabolic Epoxidation Is a Critical Step for the Development of Benzbromarone-Induced Hepatotoxicity 期刊论文 Wang Hui;Peng Ying;Zhang Tingjian;Lan Qunsheng;Zhao Huimin;Wang Wenbao;Zhao Yufei;Wang Xu;Pang Jianxin;Wang Shaojie;Zheng Jiang
8 Nitidine Chloride-Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism 期刊论文 Mao Xu;Wang Jian;Wang Qian;Yang Lan;Li Yilin;Lin Hao;Peng Ying;Zheng Jiang
9 Urinary Methyleugenol-deoxyadenosine Adduct as a Potential Biomarker of Methyleugenol Exposure in Rats 期刊论文 Feng Yukun;Wang Saide;Wang Hui;Peng Ying;Zheng Jiang
10 Evidence for Polyamine, Biogenic Amine, and Amino Acid Adduction Resulting from Metabolic Activation of Diosbulbin B 期刊论文 Zhang Zhengyu;Li Hui;Li Wei;Feng Yukun;Hu Zixia;Zhou Shenzhi;Zhang Na;Peng Ying;Zheng Jiang
11 Metabolic Activation of Tofacitinib Mediated by Myeloperoxidase in Vitro 期刊论文 Guo Xiucai;Jia Yudi;Han Lingling;Zhao Yanhong;Li Wei;Zhang Zhengyu;Peng Ying;Zheng Jiang
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