分子间相互作用对经皮给药贴剂的释药特性及生物粘附性的影响机制及分子基础的研究

81773665
2017
H3408.药剂学
方亮
面上项目
教授
沈阳药科大学
54万元
生物粘附性;经皮给药贴剂;释放动力学;压敏胶;分子间相互作用
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 The role of carboxyl group of pressure sensitive adhesive in controlled release of propranolol in transdermal patch: Quantitative determination of ionic interaction and molecular mechanism characterization 期刊论文 Yang Degong;Wan Xiaocao;Quan Peng;Liu Chao;Fang Liang
2 一种奥昔布宁经皮吸收贴剂及其制备和应用 专利 方亮;刘超;权鹏;王蔚
3 Mechanistic insights of the controlled release capacity of polar functional group in transdermal drug delivery system: the relationship of hydrogen bonding strength and controlled release capacity 期刊论文 Luo Zheng;Liu Chao;Quan Peng;Yang Degong;Zhao Hanqing;Wan Xiaocao;Fang Liang
4 Molecular mechanism of ion-pair releasing from acrylic pressure sensitive adhesive containing carboxyl group: Roles of doubly ionic hydrogen bond in the controlled release process of bisoprolol ion-pair 期刊论文 Hanqing Zhao;Chao Liu;Degong Yang;Xiaocao Wan;Rui Shang;Peng Quan;Liang Fang
5 一种罗替戈汀经皮吸收贴剂及其制备和应用 专利 方亮;刘超;权鹏;曲鑫
6 Mechanistic Insights of the Critical Role of Hydrogen Donor in Controlling Drug Release From Acrylate Adhesive 期刊论文 Luo Zheng;Liu Chao;Zhang Peng;Quan Peng;Cao Xingzhong;Fang Liang
7 Mechanistic insights of the controlled release properties of amide adhesive and hydroxyl adhesive 期刊论文 Luo Zheng;Wan Xiaocao;Liu Chao;Fang Liang
8 Investigation of molecular mobility of pressure-sensitive-adhesive in oxybutynin patch in vitro and in vivo: Effect of sorbitan monooleate on drug release and patch mechanical property 期刊论文 Wang Wei;Liu Chao;Luo Zheng;Wan Xiaocao;Fang Liang
9 A systematic approach to determination of permeation enhancer action efficacy and sites: Molecular mechanism investigated by quantitative 期刊论文 Yang Degong;Liu Chao;Quan Peng;Fang Liang
10 Investigation of Effect of Isopropyl Palmitate on Drug Release from Transdermal Patch and Molecular Dynamics Study 期刊论文 Ruan Jiuheng;Wan Xiaocao;Quan Peng;Liu Chao;Fang Liang
11 Molecular mechanism of high capacity-high release transdermal drug delivery patch with carboxyl acrylate polymer: Roles of ion-ion repulsion and bond 期刊论文 Yang Degong;Liu Chao;Quan Peng;Fang Liang
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