复杂生物体系中关键功能代谢物筛选的新方法、新技术研究
21435006
2014
B0401.分离与分析
许国旺
重点项目
研究员
中国科学院大连化学物理研究所
350万元
复杂生物样品;代谢物-蛋白质互作;功能代谢组学;高覆盖度代谢组
2015-01-01到2019-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Muscle-liver substrate fluxes in exercising humans and the potential effects on hepatic metabolism | 期刊论文 | Hu Chunxiu;Miriam Hoene;Peter Plomgaard;Jakob S Hansen;Zhao Xinjie;Li Jia;Wang Xiaolin;Jens O Clemmesen;Niels H Secher;Hans U Haring;Rainer Lehmann;Xu Guowang;Cora Weigert |
| 2 | Serum or plasma, what is the difference? Investigations to facilitate the sample material selection decision making process for complex analytical studies | 期刊论文 | Liu Xinyu;Hoene Miriam;Wang Xiaolin;Yin Peiyuan;Hans-Ulrich Haring;Xu Guowang;Rainer Lehmann |
| 3 | Molecular interaction study of flavonoids with humanserum albumin using native mass spectrometry and molecular modeling | 期刊论文 | Wang Bohong;Qin Qian;Chang Mengmeng;Li Shuyan;Shi Xianzhe;Xu Guowang |
| 4 | 一种拟靶向代谢组学分析的离子对挑选方法 | 专利 | 许国旺;王利超;苏本哲;赵欣捷;曾仲大;李超;路鑫;林晓慧 |
| 5 | Recent advances in using mass spectrometry for mitochondrial metabolomics and lipidomics - A review | 期刊论文 | Liu Xinyu;Xu Guowang |
| 6 | Optimization of large-scale pseudotargeted metabolomics method based on liquid chromatography-mass spectrometry | 期刊论文 | Luo Ping;Yin Peiyuan;Zhang Weijian;Zhou Lina;Lu Xin;Lin Xiaohui;Xu Guowang |
| 7 | Plasma lipidomics reveals potential lipid markers of major depressive disorder. | 期刊论文 | Liu Xinyu;Li Jia;Zheng Peng;Zhao Xinjie;Zhou Chanjuan;Hu Chunxiu;Hou Xiaoli;Wang Haiyang;Xie Peng;Xu Guowang |
| 8 | 一种通用的大规模代谢组学数据校正方法 | 专利 | 许国旺;赵燕妮;郝志强;路鑫;林晓惠;赵春霞;赵洁妤;张俊杰;李艳丽;李丽丽 |
| 9 | 羧甲基化的聚乙烯亚胺修饰的磁性纳米材料及应用 | 专利 | 许国旺;常蒙蒙;秦倩;王博弘;石先哲 |
| 10 | ntegrated Metabolomics and Lipidomics Analyses Reveal Metabolic Reprogramming in Human Glioma with IDH1 Mutation | 期刊论文 | Zhou Lina;Wang Zhichao;Hu Chunxiu;Zhang Chaoqi;Petia Kovatcheva-Datchary;Liu Shasha;Ren Feifei;Yu Di;Yin Peiyuan;Wang Xiaolin;Li Yanli;Hou Xiaoli;Piao Hailong;Lu Xin;Zhang Yi;Xu Guowang |
| 11 | Parallel derivatization strategy coupled with liquid chromatography-mass spectrometry for broad coverage of steroid hormones | 期刊论文 | Qin Qian;Feng Disheng;Hu Chunxiu;Wang Bohong;Chang Mengmeng;Liu Xinyu;Shi Xianzhe;Xu Guowang |
| 12 | Carboxymethylated polyethylenimine modified magnetic nanoparticles for specifically purification of His-tagged protein | 期刊论文 | Chang Mengmeng;Qin Qian;Wang Bohong;Xia Tian;lv Wangjie;Sun Xiaoshan;Shi Xianzhe;Xu Guowang |
| 13 | Lysophosphatidylcholines activate PPAR delta and protect human skeletal muscle cells from lipotoxicity | 期刊论文 | Klingler Christian;Zhao Xinjie;Adhikary Till;Li Jia;Xu Guowang;Haring Hans Ulrich;Schleicher Erwin;Lehmann Rainer;Weigert Cora |
| 14 | Linking Bioenergetic Function of Mitochondria to Tissue-Specific Molecular Fingerprints | 期刊论文 | Lisa Kappler;Miriam Hoene;Hu Chunxiu;Christine von Törne;Li Jia;Daniel Bleher;Christoph Hoffmann;Anja Böhm;Laxmikanth Kollipara;Hans Zischka;Alfred Königsrainer;Hans-Ulrich Häring;Andreas Peter;Xu Guowang;Albert Sickmann;Stefanie Hauck;Cora Weigert;Rainer Lehmann |
| 15 | MYC-driven Inhibition of the Glutamate-Cysteine Ligase Promotes Glutathione Depletion in Liver Cancer | 期刊论文 | Brittany Anderton;Roman Camarda;Sanjeev Balakrishnan;Asha Balakrishnan;Rebecca A. Kohnz;Lionel Lim;Kimberly J. Evason;Olga Momcilovic;Klaus Kruttwig;Huang Qiang;Xu Guowang;Daniel K. Nomura;Andrei Goga |
| 16 | Discovery and Validation of Plasma Biomarkers for Major Depressive Disorder Classification Based on Liquid Chromatography-Mass Spectrometry | 期刊论文 | Liu Xinyu;Zheng Peng;Zhao Xinjie;Zhang Yuqing;Hu Chunxiu;Li Jia;Zhao Jieyu;Zhou Jingjing;Xie Peng;Xu Guowang |
| 17 | A Novel Strategy for Large-Scale Metabolomics Study by Calibrating Gross and Systematic Errors in Gas Chromatography-Mass Spectrometry | 期刊论文 | Zhao Yanni;Hao Zhiqiang;Zhao Chunxia;Zhao Jieyu;Zhang Junjie;Li Yanli;Li Lili;Huang Xin;Lin Xiaohui;Zeng Zhongda;Lu Xin;Xu Guowang |
| 18 | 一种三维液相色谱分离系统 | 专利 | 许国旺;王霜原;石先哲 |
| 19 | Online Three Dimensional Liquid Chromatography/Mass Spectrometry Methodfor the Separation of Complex Samples | 期刊论文 | Wang Shuangyuan;Shi Xianzhe;Xu Guowang |
| 20 | Development of plasma pseudotargeted metabolomics method based on ultra-high performance liquid chromatography-mass spectrometry, | 期刊论文 | Zheng Fujian;Zhao Xinjie;Zeng Zhongda;Wang Lichao;Lv Wangjie;Wang Qingqing;Xu Guowang |
| 21 | 一种高选择、高灵敏富集衍生的化学选择纳米探针及其制备方法和应用 | 专利 | 许国旺;李华;石先哲;乔利珍 |
| 22 | 一种基于液相色谱-质谱联用的高覆盖脂质组学分析方法 | 专利 | 许国旺;轩秋慧;胡春秀;路鑫 |
| 23 | A large-scale, multi-center serum metabolite biomarkers identification study for the early detection of hepatocellular carcinoma | 期刊论文 | Luo Ping;Yin Peiyuan;Hua Rui;Tan Yexiong;Li Zaifang;Qiu Gaokun;Yin Zhenyu;Xie Xingwang;Wang Xiaomei;Chen Wenbin;Zhou Lina;Wang Xiaolin;Li Yanli;Chen Hongsong;Gao Ling;Lu Xin;Wu Tangchun;Wang Hongyang;Niu Junqi;Xu Guowang |
| 24 | Development of a High Coverage Pseudotargeted Lipidomics Method Based on Ultra-High Performance Liquid Chromatography-Mass Spectrometry | 期刊论文 | Xuan Qiuhui;Hu Chunxiu;Yu Di;Wang Lichao;Zhou Yang;Zhao Xinjie;Li Qi;Hou Xiaoli;Xu Guowang |
| 25 | Enhancement of mitochondrial biogenesis and paradoxical inhibition of lactate dehydrogenase mediated by 14-3-3η in oncocytomas | 期刊论文 | Feng Jie;Zhang Qi;Li Chuzhong;Zhou Yang;Zhao Sida;Hong Lichuan;Song Qi;Yu Shenyuan;Hu Chunxiu;Wang Herui;Mao Chengyuan;Matthew J. Shepard;Hao Shuyu;Gifty Dominah;Sun Mitchell;Wang Hong;Deric M. Park;Mark R. Gilbert;Xu Guowang;Zhuang Zhengping;Zhang Yazhuo |
| 26 | 一种同时分离代谢组和脂质组组份的液相色谱分析方法及其应用 | 专利 | 许国旺;王霜原;石先哲;周丽娜 |
| 27 | Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery | 期刊论文 | Hansen Jakob S.;Zhao Xinjie;Irmler Martin;Liu Xinyu;Hoene Miriam;Scheler Mika;Li Yanjie;Beckers Johannes;de Angelis Martin Hrabe;Haering Hans-Ulrich;Pedersen Bente K.;Lehmann Rainer;Xu Guowang;Plomgaard Peter;Weigert Cora |
| 28 | Plasma Lipidomics Investigation of Hemodialysis Effects by Using Liquid Chromatography-Mass Spectrometry | 期刊论文 | Wang Lichao;Hu Chunxiu;Liu Shuxin;Chang Ming;Gao Peng;Wang Lili;Pan Zaifa;Xu Guowang |
| 29 | A comprehensive strategy for studying protein-metabolite interactions by metabolomics and native mass spectrometry | 期刊论文 | Qin Qian;Wang Bohong;Wang Jiayue;Chang Mengmeng;Xia Tian;Shi Xianzhe;Xu Guowang |
| 30 | Recent advances in development and characterization of stationary phases for hydrophilic interaction chromatography | 期刊论文 | Qiao Lizhen;Shi Xianzhe;Xu Guowang |
| 31 | Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans | 期刊论文 | Randrianarisoa Elko;Lehn Stefan Angela;Wang Xiaolin;Hoene Miriam;Peter Andreas;Heinzmann Silke S;Zhao Xinjie;Koenigsrainer Ingmar;Koenigsrainer Alfred;Balletshofer Bernd;Machann Juergen;Schick Fritz;Fritsche Andreas;Haering Hans Ulrich;Xu Guowang;Lehmann Rainer;Stefan Norbert |
| 32 | Discoveryand validation of potential urinary biomarkers for bladder cancer diagnosisusing a pseudotargeted GC-MS metabolomics method | 期刊论文 | Zhou Yang;Song Ruixiang;Ma Chong;Zhou Lina;Liu Xinyu;Yin Peiyuan;Zhang Zhensheng;Sun Yinghao;Xu Chuanliang;Lu Xin;Xu Guowang |
| 33 | Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer | 期刊论文 | Shao Yaping;Ye Guozhu;Ren Shancheng;Piao Hai Long;Zhao Xinjie;Lu Xin;Wang Fubo;Ma Wang;Li Jia;Yin Peiyuan;Xia Tian;Xu Chuanliang;Yu Jane J;Sun Yinghao;Xu Guowang |
| 34 | Highly efficient solid-phase derivatization of sugar phosphates with titanium-immobilized hydrophilic polydopamine-coated silica. | 期刊论文 | Qin Qian;Wang Bohong;Chang Mengmeng;Zhou Zhihui;Shi Xianzhe;Xu Guowang |
| 35 | Ion-Pair Selection Method for Pseudotargeted Metabolomics Based on SWATH MS Acquisition and Its Application in Differential Metabolite Discovery of Type 2 Diabetes | 期刊论文 | Wang Lichao;Su Benzhe;Zeng Zhongda;Li Chao;Zhao Xinjie;Lv Wangjie;Xuan Qiuhui;Ouyang Yang;Zhou Lina;Yin Peiyuan;Peng Xiaojun;Lu Xin;Lin Xiaohui;Xu Guowang |
| 36 | Preparation of mesoporous SiO2@azobenzene-COOH chemoselective nanoprobes for comprehensive mapping of amino metabolites in human serum | 期刊论文 | Li Hua;Qin Qian;Qiao Lizhen;Shi Xianzhe;Xu Guowang |
| 37 | 一种磷酸糖类物质的富集和固相衍生预处理方法 | 专利 | 许国旺;秦倩;石先哲;王博弘 |
| 38 | 一种代谢物-蛋白质相互作用体系筛选和表征方法 | 专利 | 许国旺;王博弘;秦倩;石先哲;常蒙蒙 |
| 39 | 一种同时分析短链,中链和长链酰基辅酶A的方法 | 专利 | 许国旺;王霜原;石先哲 |
| 40 | Preparation and evaluation of surface-bonded tricationic ionic liquid silica as stationary phases for high-performance liquid chromatography | 期刊论文 | Qiao Lizhen;Shi Xianzhe;Xu Guowang |
| 41 | Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling. | 期刊论文 | Gao Peng;Yang Chunzhang;Nesvick Cody L;Feldman Michael J;Sizdahkhani Saman;Liu Huailei;Chu Huiying;Yang Fengxu;Tang Ling;Tian Jing;Zhao Shiguang;Li Guohui;Heiss John D;Liu Yang;Zhuang Zhengping;Xu Guowang |
| 42 | Application of LC-MS-based metabolomics method in differentiating septic survivors from non-survivors | 期刊论文 | Liu Zhicheng;Yin Peiyuan;Amathieu Roland;Savarin Philippe;Xu Guowang |
| 43 | Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma | 期刊论文 | Tang Ling;Zeng Jun;Geng Pengyu;Fang Chengnan;Wang Yang;Sun Mingju;Wang Changsong;Wang Jiao;Yin Peiyuan;Hu Chunxiu;Guo Lei;Yu Jane;Gao Peng;Li Enyou;Zhuang Zhengping;Xu Guowang;Liu Yang |
| 44 | Plasma Metabolomics Profiling of Maintenance Hemodialysis Based on Capillary Electrophoresis - Time of Flight Mass Spectrometry | 期刊论文 | Liu Shuxin;Wang Lichao;Hu Chunxiu;Huang Xin;Liu Hong;Xuan Qiuhui;Lin Xiaohui;Peng Xiaojun;Lu Xin;Chang Ming;Xu Guowang |
| 45 | Comprehensive Analysis of Short-, Medium-, and Long-Chain AcylCoenzyme A by Online Two-Dimensional Liquid Chromatography/Mass Spectrometry | 期刊论文 | Wang Shuangyuan;Wang Zhichao;Zhou Lina;Shi Xianzhe;Xu Guowang |
| 46 | Simultaneous metabolomics and lipidomics analysis based on novel heart-cutting two-dimensional liquid chromatography-mass spectrometry | 期刊论文 | Wang Shuangyuan;Zhou Lina;Wang Zhichao;Shi Xianzhe;Xu Guowang |
| 47 | Modified metabolite mapping by liquid chromatography-high resolution mass spectrometry using full scan/all ion fragmentation/neutral loss acquisition | 期刊论文 | Li Hua;Qin Qian;Shi Xianzhe;He Jun;Xu Guowang |
| 48 | Multidimensional Liquid Chromatography-Mass Spectrometry for Metabolomics and Lipidomics | 期刊论文 | Lv Wangjie;Shi Xianzhe;Wang Shuangyuan;Xu Guowang |
| 49 | Facile synthesis of Fe3O4@polyethyleneimine modified with 4-formylphenylboronic acid for the highly selective extraction of major catecholamines from human urine | 期刊论文 | Qin Qian;Li Hua;Shi Xianzhe;Xu Guowang |
| 50 | Recent development of ionic liquid stationary phases for liquid chromatography | 期刊论文 | Shi Xianzhe;Qiao Lizhen;Xu Guowang |
| 51 | 一种从生物体代谢物中筛选靶蛋白配体的方法 | 专利 | 许国旺;王博弘;石先哲;秦倩 |
| 52 | Rapid screening and locking of potential risk substances based on liquid chromatography-high resolution mass spectrometry | 期刊论文 | Fu Yanqing;Zhang Yanhui;Zhou Zhihui;Lu Xin;Lin Xiaohui;Zhao Chunxia;Xu Guowang |
| 53 | Integration of Metabolomics and Transcriptomics Reveals Major Metabolic Pathways and Potential Biomarker Involved in Prostate Cancer | 期刊论文 | Ren Shancheng;Shao Yaping;Zhao Xinjie;Hong Christopher S.;Wang Fubo;Lu Xin;Li Jia;Ye Guozhu;Yan Min;Zhuang Zhengping;Xu Chuanliang;Xu Guowang;Sun Yinghao |
| 54 | Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection | 期刊论文 | Wu Qi;Zhou Lina;Sun Xin;Yan Zhongfang;Hu Chunxiu;Wu Junping;Xu Long;Li Xue;Liu Huiling;Yin Peiyuan;Li Kuan;Zhao Jieyu;Li Yanli;Wang Xiaolin;Li Yu;Zhang Qiuyang;Xu Guowang;Chen Huaiyong |
| 55 | The development of plasma pseudotargeted GC-MS metabolic profiling and its application in bladder cancer. | 期刊论文 | Zhou Yang;Song Ruixiang;Zhang Zhensheng;Lu Xin;Zeng Zhongda;Hu Chunxiu;Liu Xinyu;Li Yanli;Hou Jianguo;Sun Yinghao;Xu Chuanliang;Xu Guowang |
| 56 | 一种基于混合生物样本的酰基肉碱大规模定性方法 | 专利 | 许国旺;于迪;周丽娜 |
| 57 | Integration of lipidomics and transcriptomics unravels aberrant lipid metabolism and defines cholesteryl oleate as potential biomarker of prostate cancer. | 期刊论文 | Li Jia;Ren Shancheng;Piao Hai-Long;Wang Fubo;Yin Peiyuan;Xu Chuanliang;Lu Xin;Ye Guozhu;Shao Yaping;Yan Min;Zhao Xinjie;Sun Yinghao;Xu Guowang |
| 58 | Strategy for Comprehensive Identification of Acylcarnitines Based on Liquid Chromatography-High-Resolution Mass Spectrometry | 期刊论文 | Yu Di;Zhou Lina;Xuan Qiuhui;Wang Lichao;Zhao Xinjie;Lu Xin;Xu Guowang |
| 59 | Current and future perspectives of functional metabolomics in disease studies–A review | 期刊论文 | Yan Min;Xu Guowang |
| 60 | Comprehensive Strategy to Construct In-House Database for Accurate and Batch Identification of Small Molecular Metabolites | 期刊论文 | Zhao Xinjie;Zeng Zhongda;Chen Aiming;Lu Xin;Zhao Chunxia;Hu Chunxiu;Zhou Lina;Liu Xinyu;Wang Xiaolin;Hou Xiaoli;Ye Yaorui;Xu Guowang |
| 61 | An alignment algorithm for LC-MS-based metabolomics dataset assisted by MS/MS information | 期刊论文 | Li Lili;Ren Weijie;Kong Hongwei;Zhao Chunxia;Zhao Xinjie;Lin Xiaohui;Lu Xin;Xu Guowang |
| 62 | Surface-bonded amide-functionalized imidazolium ionic liquid as stationary phase for hydrophilic interaction liquid chromatography | 期刊论文 | Qiao Lizhen;Lv Wangjie;Chang Mengmeng;Shi Xianzhe;Xu Guowang |
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