鲨鱼天然抗体IgNAR超稳定分子机制及其特异性纳米抗体(Nb/PD-L1)筛选鉴定与抗肺癌活性研究

81673345
2016
H3404.生物技术药物
郑文云
面上项目
教授
华东理工大学
54万元
噬菌体纳米抗体库;抗肺癌生物活性;程序性死亡因子1配体1纳米抗体制备;鲨鱼天然抗体IgNAR;超稳定性分子机制
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Multiple targeting strategies achieve novel protein drug delivery into proapoptosis lung cancer cells by precisely inhibiting survivin 期刊论文 Hu Fabiao;Yan Ting;Guo Wei;Liu Qiuli;Han Myong Hun;Liu Chang;Liu Yuping;Zheng Wenyun;You Fang;Yang Yi;Zhang Wenliang;Ma Xingyuan
2 Designing and constructing a phage display synthesized single domain antibodies library based on camel VHH frame for screening and identifying humanized TNF-α-specific nanobody 期刊论文 JifanNie;XingyuanMa;FabiaoHu;HuiMiao;XinFeng;PeiwenZhang;Myong HunHan;FangYou;YiYang;WenlianZhang;Wenyun Zheng
3 Enhanced Biosynthesis Performance of Heterologous Proteins in CHO-K1 Cells Using CRISPR-Cas9 期刊论文 Wang Wenpeng;Zheng Wenyun;Hu Fengzhi;He Xiujuan;Wu Dong;Zhang Wenliang;Liu Haipeng;Ma Xingyuan
4 A CqFerritin protein inhibits white spot syndrome virus infection via regulating iron ions in red claw crayfish Cherax quadricarinatus 期刊论文 Chen Xiao-Xiao;Li Yan-Yao;Chang Xue-Jiao;Xie Xiao-Lu;Liang Yu-Ting;Wang Ke-Jian;Zheng Wen-Yun;Liu Hai-Peng
5 基于鲨鱼抗体可变区V-NAR的噬菌体文库及其构建方法 专利 郑文云;马兴元;刘秋丽
6 靶向TNF-α的人源化纳米抗体及其制备和用途 专利 马兴元;聂绩凡;郑文云
7 抗PD-L1纳米抗体及其应用 专利 郑文云;马兴元;刘秋丽
8 PEGylated-PLGA Nanoparticles Coated With pH Responsive Tannic acid-Fe(III) Complexes for Reduced Premature Doxorubicin Release and Enhanced Targeting in Breast Cancer 期刊论文 Fabiao Hu;Ruihuan Zhang;Wei Guo;Ting Yan;Xingyuan Ma;Jiandu Lei;Wenyun Zheng
9 纳米抗体靶向性泛素化降解细胞内源性Survivin的组合物及其应用 专利 马兴元;刘畅;郑文云;胡发彪;郭伟;刘秋丽;付云辉
10 Epithelial V-like antigen 1 promotes hepatocellular carcinoma growth and metastasis via the ERBB-PI3K-AKT pathway 期刊论文 Ni QianZhi;Chen Zhenhua;Zheng Qianwen;Xie Dong;Li Jing-Jing;Cheng Shuqun;Ma Xingyuan
11 Elucidating respective functions of two domains BIR and C-helix of human IAP survivin for precise targeted regulating mitotic cycle, apoptosis and autophagy of cancer cells 期刊论文 Hu Fabiao;Pan Daxia;Zheng Wenyun;Yan Ting;He Xiujuan;Ren Fuzheng;Lu Yiming;Ma Xingyuan
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