基于蛋白质组和代谢组动态变化分析的大气细颗粒物健康效应研究新方法

91543201
2015
B0401.分离与分析
张丽华
重大研究计划
研究员
中国科学院大连化学物理研究所
280万元
代谢组;蛋白质组;大气细颗粒物;定量分析;健康效应
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Enzymatic Reactor with Trypsin Immobilized on Graphene Oxide Modified Polymer Microspheres To Achieve Automated Proteome Quantification 期刊论文 Yuan Huiming;Zhang Shen;Zhao Baofeng;Weng Yejing;Zhu Xudong;Li Senwu;Zhang Lihua;Zhang Yukui
2 一种蛋白质变体的定性定量方法 专利 张丽华;王芷婷;刘健慧;单亦初;杨开广;梁振;张玉奎
3 In-Depth Proteome Coverage by Improving Efficiency for Membrane Proteome Analysis 期刊论文 Zhao Qun;Fang Fei;Shan Yichu;Sui Zhigang;Zhao Baofeng;Liang Zhen;Zhang Lihua;Zhang Yukui
4 Hazy Weather-Induced Variation in Environmental Behavior of PCDD/Fs and PBDEs in Winter Atmosphere of A North China Megacity 期刊论文 Cao Rong;Zhang Haijun;Zhao Lijuan;Zhang Yichi;Geng Ningbo;Teng Man;Zou Lili;Gao Yuan;Ni Yuwen;Fu Qiang;Chen Jiping
5 Hydrophilic GO/Fe3O4/Au/PEG nanocomposites for highly selective enrichment of glycopeptides 期刊论文 Jiang Bo;Wu Qi;Deng Nan;Chen Yuanbo;Zhang Lihua;Liang Zhen;Zhang Yukui
6 Surface sieving coordinated IMAC material for purification of His-tagged proteins 期刊论文 Li Senwu;Yang Kaiguang;Liu Lukuan;Zhao Baofeng;Chen Yuanbo;Li Xiao;Zhang Lihua;Zhang Yukui
7 一种用于非暴露式气管滴注的实验鼠固定装置 专利 耿柠波;宋肖垚;蔡振刚;俞柯杰;高媛;张海军;陈吉平
8 3-Carboxybenzoboroxole Functionalized Polyethylenimine Modified Magnetic Graphene Oxide Nanocomposites for Human Plasma Glycoproteins Enrichment under Physiological Conditions 期刊论文 Wu Qiong;Jiang Bo;Weng Yejing;Liu Jianxi;Li Senwu;Hu Yechen;Yang Kaiguang;Liang Zhen;Zhang Lihua;Zhang Yukui
9 Hazy Weather-Induced Variation in Environmental Behavior of PCDD/Fs and PBDEs in Winter Atmosphere of A North China Megacity 期刊论文 Cao Rong;Zhang Haijun;Zhao Lijuan;Zhang Yichi;Geng Ningbo;Teng Man;Zou Lili;Gao Yuan;Ni Yuwen;Fu Qiang;Chen Jiping
10 代谢组学技术在环境毒理学研究中的应用 期刊论文 耿柠波;张海军;王菲迪;任晓倩;张保琴;陈吉平
11 Hydrogen-bond interaction assisted branched copolymer HILIC material for separation and N-glycopeptides enrichment 期刊论文 Shao Wenya;Liu Jianxi;Yang Kaiguang;Liang Yu;Weng Yejing;Li Senwu;Liang Zhen;Zhang Lihua;Zhang Yukui
12 High Anti-Interfering Profiling of Endogenous Glycopeptides for Article Human Plasma by the Dual-Hydrophilic Metal-Organic Framework 期刊论文 Peng Jiaxi;Hu Yechen;Zhang Hongyan;Wan Lihong;Wang Li;Liang Zhen;Zhang Lihua;Wei Ren'an
13 Cell-imprinted polydimethylsiloxane for the selective cell adhesion 期刊论文 Liu Lukuan;Yang Kaiguang;Dai Zhongpeng;Liang Zhen;Zhang Lihua;Peng Xiaojun;Zhang Yukui
14 一种表面电荷改性的反相色谱分离材料及制备和应用 专利 张丽华;刘键熙;杨开广;李森武;吴琼;张玉奎
15 Macro-mesoporous organosilica monoliths with bridged-ethylene and terminal-vinyl: High-density click functionalization for chromatographic separation 期刊论文 Wu Ci;Liang Yu;Zhu Xudong;Zhao Qun;Fang Fei;Zhang Xiaodan;Liang Zhen;Zhang Lihua;Zhang Yukui
16 Diurnal variations of atmospheric polycyclic aromatic hydrocarbons (PAHs) during three sequent winter haze episodes in Beijing, China 期刊论文 Cao Rong;Zhang Haijun;Geng Ningbo;Fu Qiang;Teng Man;Zou Lili;Gao Yuan;Chen Jiping
17 Advances of ionic liquids-based methods for protein analysis 期刊论文 Zhao Qun;Chu Hongwei;Zhao Baofeng;Liang Zhen;Zhang Lihua;Zhang Yukui
18 一种基于离子液体的膜蛋白质复合物提取方法及其应用 专利 张丽华;褚宏伟;赵宝锋;孙瑞;杨开广;梁振;张玉奎
19 一种高通量蛋白质样品预处理设备 专利 张丽华;戴忠鹏;袁辉明;杨开广;张玉奎
20 短链氯化石蜡(SCCPs)和多环芳烃(PAHs)联合暴露对HepG2细胞抗氧化系统的影响 期刊论文 王菲迪;张海军;耿柠波;任晓倩;张保琴;宫玉峰;陈吉平
21 一种基于二级质谱的全离子监测定量方法 专利 张丽华;赵群;单亦初;张珅;杨开广;张玉奎
22 一种基于等重二甲基化标记的多重蛋白质定量方法 专利 张丽华;刘健慧;周愿;杨开广张玉奎;张玉奎
23 MULTIPLEX PROTEOME QUANTIFICATION METHOD BASED ON ISOBARIC DIMETHYL LABELING 专利 张丽华;刘健慧;周愿;杨开广;张玉奎
24 基于二甲基化多重标记及特征碎片离子的绝对定量方法 专利 张丽华;刘健慧;周愿;单亦初;杨开广;张玉奎
25 A Multiplex Fragment-Ion-Based Method for Accurate Proteome Quantification 期刊论文 Liu Jianhui;Zhou Yuan;Shan Yichu;Zhao Baofeng;Hu Yechen;Sui Zhigang;Liang Zhen;Zhang Lihua;Zhang Yukui
26 一种基于快速扫描和无动态排除的质谱采集模式 专利 张丽华;张珅;单亦初;赵群;周愿;杨开广;张玉奎
27 "Thiol-ene" grafting of silica particles with three-dimensional branched copolymer for HILIC/cation-exchange chromatographic separation and N-glycopeptide enrichment 期刊论文 Shao Wenya;Liu Jianxi;Liang Yu;Yang Kaiguang;Min Yi;Zhang Xiaodan;Liang Zhen;Zhang Lihua;Zhang Yukui
28 Cleavable hydrophobic derivatization strategy for enrichment and identification of phosphorylated lysine peptides 期刊论文 Hu Yechen;Li Yang;Gao Hang;Jiang Bo;Zhang Xiaodan;Li Xiao;Wu Qiong;Liang Zhen;Zhang Lihua;Zhang Yukui
29 Recent Advances in Multidimensional Separation for Proteome Analysis 期刊论文 Yuan Huiming;Jiang Bo;Zhao Baofeng;Zhang Lihua;Zhang Yukui
30 Integrated platform with combination of on-line protein digestion, isotope dimethyl labeling and multidimensional peptide separation for high-throughput proteome quantification 期刊论文 Zhang Shen;Yuan Huiming;Zhao Baofeng;Zhang Lihua;Zhang Yukui
31 Aptamer functionalized magnetic graphene oxide nanocomposites for highly selective capture of histones 期刊论文 Chen Yuanbo;Jiang Bo;Hu Yechen;Deng Nan;Zhao Baofeng;Li Xiao;Liang Zhen;Zhang Lihua;Zhang Yukui
32 Site-Specific Quantification of Persulfidome by Combining an Isotope-Coded Affinity Tag with Strong Cation-Exchange-Based Fractionation 期刊论文 Wu Qiong;Zhao Baofeng;Wang Yejing;Shan Yichu;Li Xiao;Hu Yechen;Liang Zhen;Yuan Huiming;Zhang Lihua;Zhang Yukui
33 一种新型硅胶基质表面修饰方法及其应用 专利 张丽华;朱旭东;梁玉;杨开广;李洋;梁振;张玉奎
34 Effective isolation of exosomes with polyethylene glycol from cell culture supernatant for in-depth proteome profiling 期刊论文 Weng Yejing;Sui Zhigang;Shan Yichu;Hu Yechen;Chen Yuanbo;Zhang Lihua;Zhang Yukui
35 Artificial Antibody with Site-Enhanced Multivalent Aptamers for Specific Capture of Circulating Tumor Cells 期刊论文 Liu Lukuan;Yang Kaiguang;Gao Hang;Li Xiao;Chen Yuanbo;Zhang Lihua;Peng Xiaojun;Zhang Yukui
36 4-Mercaptophenylboronic acid functionalized graphene oxide composites: Preparation, characterization and selective enrichment of glycopeptides 期刊论文 Jiang Bo;Qu Yanyan;Zhang Lihua;Liang Zhen;Zhang Yukui
37 表面阳离子功能化氧化石墨烯材料及制备和应用 专利 张丽华;江波;胡晔晨;杨开广;梁振;张玉奎
38 一种细胞膜蛋白质富集纯化方法 专利 张丽华;方菲;赵群;随志刚;杨开广;张玉奎
39 一种PM2.5颗粒对人肺细胞内自由基代谢通路影响的评估方法 专利 宋肖垚;陈吉平;耿柠波;张海军;张亦弛
40 一种精确定量非暴露式气管滴注装置 专利 耿柠波;宋肖垚;蔡振刚;俞柯杰;曹蓉;张海军;陈吉平
41 Isolation and identification of phosphorylated lysine peptides by retention time difference combining dimethyl labeling strategy 期刊论文 Hu Yechen;Weng Yejing;Jiang Bo;Li Xiao;Zhang Xiaodan;Zhao Baofeng;Wu Qiong;Liang Zhen;Zhang Lihua;Zhang Yukui
42 "Thiol-ene" grafting of silica particles with three-dimensional branched copolymer for HILIC/cation-exchange chromatographic separation and N-glycopeptide enrichment 期刊论文 Shao Wenya;Liu Jianxi;Liang Yu;Yang Kaiguang;Min Yi;Zhang Xiaodan;Liang Zhen;Zhang Lihua;Zhang Yukui
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