恶性肿瘤关键遗传变异介导的RNA结合蛋白调控网络扰动模型构建与分析
31970646
2019
C0608.生物数据资源与分析方法
李永生
面上项目
教授
海南医学院
58万元
生物大数据;网络构建;系统生物学;多源信息融合;人
2020-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Pan-cancer characterization of expression and clinical relevance of m6A-related tissue-elevated long non-coding RNAs | 期刊论文 | Kang Xu;Yangyang Cai;Mengying Zhang;Haozhe Zou;Zhenghong Chang;Donghao Li;Jing Bai;Juan Xu;Yongsheng Li |
| 2 | Alternative splicing perturbation landscape identifies RNA binding proteins as potential therapeutic targets in cancer | 期刊论文 | Junyi Li;Tao Pan;Liuxin Chen;Qi Wang;Zhenghong Chang;Weiwei Zhou;Xinhui Li;Gang Xu;Xia Li;Yongsheng Li;Yunpeng Zhang |
| 3 | 非编码RNA基因协同调控作用的预测方法 | 专利 | 李永生;徐娟;李霞 |
| 4 | 整合免疫多肽组数据识别非编码区域的免疫表位的鉴定方法 | 专利 | 徐娟;李永生;潘涛 |
| 5 | “科教融合、全程多元、知行合一”的生物信息学专业创新教学体系研究与实践 | 奖励 | 徐娟;李永生;张云鹏;邵婷婷 |
| 6 | ImmReg: the regulon atlas of immune-related pathways across cancer types | 期刊论文 | Tiantongfei Jiang;Weiwei Zhou;Zhenghong Chang;Haozhe Zou;Jing Bai;Qisen Sun;Tao Pan;Juan Xu;Yongsheng Li;Xia Li |
| 7 | RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site | 期刊论文 | George Jasmine;Li Yongsheng;Kadamberi Ishaque P.;Parashar Deepak;Tsaih Shirng-Wern;Gupta Prachi;Geethadevi Anjali;Chen Changliang;Ghosh Chandrima;Sun Yunguang;Mittal Sonam;Ramchandran Ramani;Rui Hallgeir;Lopez-Berestein Gabriel;Rodriguez-Aguayo Cristian;Leone Gustavo;Janet S. Rader;Anil K. Sood;Madhusudan Dey;Sunila Pradeep;Pradeep Chaluvally-Raghavan |
| 8 | Pan-cancer assessment of mutational landscape in intrinsically disordered hotspots reveals potential driver genes | 期刊论文 | Haozhe Zou;Tao Pan;Yueying Gao;Renwei Chen;Si Li;Jing Guo;Zhanyu Tian;Gang Xu;Juan Xu;Yanlin Ma;Yongsheng Li |
| 9 | MIR22HG acts as a tumor suppressor via TGFβ/SMAD signaling and facilitates immunotherapy in colorectal cancer | 期刊论文 | Juan Xu;Tingting Shao;Mingxu Song;Yunjin Xie;Jialiang Zhou;Jiaqi Yin;Na Ding;Haozhe Zou;Yongsheng Li;Jiwei Zhang |
| 10 | Complex impact of DNA methylation on transcriptional dysregulation across 22 human cancer types | 期刊论文 | Zishan Wang;Jiaqi Yin;Weiwei Zhou;Jing Bai;Yunjin Xie;Kang Xu;Xiangyi Zheng;Jun Xiao;Li Zhou;Xiaolin Qi;Yongsheng Li;Xia Li;Juan Xu |
| 11 | 高等院校青年科学奖 | 奖励 | 李永生 |
| 12 | Pan-cancer characterization of immune-related lncRNAs identifies potential oncogenic biomarkers | 期刊论文 | Yongsheng Li;Tiantongfei Jiang;Weiwei Zhou;Junyi Li;Xinhui Li;Qi Wang;Xiaoyan Jin;Jiaqi Yin;Liuxin Chen;Yunpeng Zhang;Juan Xu;Xia Li |
| 13 | Systematic analysis of DNA methylation-mediated TF dysregulation on lncRNAs reveals critical roles in tumor immunity | 期刊论文 | Jiaqi Yin;Na Ding;Jiaxin Yu;Zishan Wang;Limei Fu;Yongsheng Li;Xia Li;Juan Xu |
| 14 | SORC: an integrated spatial omics resource in cancer | 期刊论文 | Weiwei Zhou;Minghai Su;Tiantongfei Jiang;Qingyi Yang;Qisen Sun;Kang Xu;Jingyi Shi;Changbo Yang;Na Ding;Yongsheng Li;Juan Xu |
| 15 | Dynamic Expression of m6A Regulators During Multiple Human Tissue Development and Cancers | 期刊论文 | Ya Zhang;Sicong Xu;Gang Xu;Yueying Gao;Si Li;Ke Zhang;Zhanyu Tian;Jing Guo;Xia Li;Juan Xu;Yongsheng Li |
| 16 | 一种识别非编码RNA多肽的方法 | 专利 | 李永生;徐娟 |
| 17 | TransLnc: a comprehensive resource for translatable lncRNAs extends immunopeptidome | 期刊论文 | Dezhong Lv;Zhenghong Chang;Yangyang Cai;Junyi Li;Liping Wang;Qiushuang Jiang;Kang Xu;Na Ding;Xia Li;Juan Xu;Yongsheng Li |
| 18 | Long noncoding RNA LINC01132 enhances immunosuppression and therapy resistance via NRF1/DPP4 axis in hepatocellular carcinoma | 期刊论文 | Jiwei Zhang;Tao Pan;Weiwei Zhou;Ya Zhang;Gang Xu;Qi Xu;Si Li;Yueying Gao;Zhengtao Wang;Juan Xu;Yongsheng Li |
| 19 | RBP EIF2S2 Promotes Tumorigenesis and Progression by Regulating MYC-Mediated Inhibition via FHIT-Related Enhancers | 期刊论文 | Jiwei Zhang;Shengli Li;Ling Zhang;Juan Xu;Mingxu Song;Tingting Shao;Zhaohui Huang;Yongsheng Li |
| 20 | 第十四届黑龙江省青年科技奖 | 奖励 | 李永生 |
| 21 | 适应新医科发展理念,医工结合创办生物信息专业 | 奖励 | 李霞;徐娟;李永生;张云鹏;肖云;白静 |
| 22 | ImmCluster: an ensemble resource for immunology cell type clustering and annotations in normal and cancerous tissues | 期刊论文 | Tiantongfei Jiang;Weiwei Zhou;Qi Sheng;Jiaxin Yu;Yunjin Xie;Na Ding;Yunpeng Zhang;Juan Xu;Yongsheng Li |
| 23 | Clinical and genomic characterization of mutational signatures across human cancers | 期刊论文 | Jianlong Liao;Jing Bai;Tao Pan;Haozhe Zou;Yueying Gao;Jing Guo;Qi Xu;Juan Xu;Yongsheng Li;Xia Li |
| 24 | Single-cell RNA binding protein regulatory network analyses reveal oncogenic HNRNPK-MYC signalling pathway in cancer | 期刊论文 | Weiwei Zhou;Qiuling Jie;Tao Pan;Jingyi Shi;Tiantongfei Jiang;Ya Zhang;Na Ding;Juan Xu;Yanlin Ma;Yongsheng Li |
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