色素衍生的生物客体探针与药物先导

20536010
2005
B0813.精细化工与专用化学品
钱旭红
重点项目
教授
华东理工大学
170万元
药物先导;人工核酸酶;色素;荧光探针;构效关系
2006-01-01到2009-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Novel naphthalimide derivatives with near-infrared emission: synthesis via photochemical cycloaromatization, fluorescence in solvents and living cell 期刊论文 Y. Liu|Y. F. Xu|L. P. Duan|X. H. Qian|Y. X. Zhang|
2 Highly efficient energy transfer in the light harvesting system composed of three kinds of boron-dipyrromethene derivatives 期刊论文 X. L. Zhang|Y. Xiao|X. H. Qian|
3 Anion recognition by a novel Fipronil-based receptor: efficient deprotonation or stable intermolecular hydrogen bonding 期刊论文 Z. Li|X. H. Qian|C. X. Liu|J. B. Wang|
4 Non-sulfur and Non-cyclic Fluorescent Sensors with High Sensitivity and Selectivity. 会议论文 钱旭红|
5 Fluorescent Molecular Sensors and Images for Cations or Guests with Biological Interests 会议论文 钱旭红|
6 Inhibition of Topoisomerase or Bcl2 Protein in vitro and vivo: Electron-deficient Chromophores of Naphthoheterocycles as Inducers for Apoptosis 会议论文 钱旭红|
7 Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor 期刊论文 J. W. Liu|Y. F. Xu|Y. X. Zhang|X. H. Qian|J. H. Li|Y. Liu|L. Y. Shen|Y. Xiao|
8 Novel Bcl-2 inhibitors: Discovery and mechanism study of small organic apoptosis-inducing agents 期刊论文 M. J. Wei|F. Liu|X. H. Qian|J. Wang|Y. T. Xu|Y. Y. Wang|Q. Xu|L. J. Jin|Y. Y. Yang|Z. C. Zhang|
9 A series of polyamide receptor based PET fluorescent sensor molecules: Positively cooperative Hg2+ ion binding with high sensitivity 期刊论文 J. B. Wang|X. H. Qian|
10 Versatile nitro-fluorophore as highly effective sensor for hypoxic tumor cells: Design, imaging and evaluation 期刊论文 Y. F. Xu|Y. You|Y. Liu|M. Dai|W. P. Zhu|Y. Xiao|X. H. Qian|
11 A Rhodamine-Based Hg2+ Sensor with High Selectivity and Sensitivity in Aqueous Solution: A NS2-Containing Receptor 期刊论文 J. H. Huang|Y. F. Xu|X. H. Qian|
12 Isomeric boron-fluorine complexes with donor-acceptor architecture: Strong solid/liquid fluorescence and large stokes shift 期刊论文 Y. Xiao|Y. Zhou|X. H. Qian|S. M. Chi|
13 A red-shift colorimetric and fluorescent sensor for Cu2+ in aqueous solution: unsymmetrical 4,5-diaminonaphthalimide with N-H deprotonation induced by metal ions 期刊论文 X. H. Qian|Y. F. Xu|J. H. Huang|
14 2,3,6,7-Tetraamino-9,9-bis(2-ethylhexyl) fluorene: New multifunctional monomer for soluble ladder-conjugated molecules and polymers 期刊论文 Y. Xiao|X. C. Li|X. H. Qian|
15 Fluorescent Molecular Sensor and Images for Metallic Cations with Biological Interests: Design, Synthesis and Structure-Property Relationship 会议论文 钱旭红|
16 A Ratiometric Fluorescent Probe Based on FRET for Imaging Hg2+ Ions in Living Cells 期刊论文 X. H. Qian|X. L. Zhang|Y. Xiao|
17 Fluorescent zinc sensors: Design, synthesis, spectra and images 会议论文 钱旭红|
18 A pair of regio-isomeric compounds acting as molecular logic gates with different functions 期刊论文 J. H. Qian|S. Y. Zhang|Y. F. Xu|X. H. Qian|
19 Trifluoromethyltriphenodioxazine: Air-stable and high-performance n-type semiconductor 期刊论文 Y. L. Guo|Y. Q. Liu|G. Yu|D. B. Zhu|Y. Xiao|J. Li|C. A. Di|X. H. Qian|
20 Non-cyclic Fluorescent Sensors with High Sensitivity and Selectivity, 会议论文 钱旭红|
21 Trace mercury (II) detection and separation in serum and water samples using a reusable bifunctional fluorescent sensor 期刊论文 T. Chen|W. P. Zhu|C. S. He|Y. F. Xu|X. H. Qian|
22 R16, a novel amonafide analogue, induces apoptosis and G(2)-M arrest via poisoning topoisomerase II 期刊论文 Y. F. Xu|Z. H. Miao|Y. X. Qin|Y. J. Cai|H. B. Luo|X. H. Qian|X. Shen|M. Huang|J. Ding|F. Yang|Y. Chen|M. Y. Geng|H. Zhu|
23 Assessment of 4-nitro-1,8-naphthalic anhydride reductase activity in homogenates of bakers' yeast by reversed-phase high-performance liquid chromatography 期刊论文 X. H. Qian|J. Q. Xu|Q. Yang|J. Samuelsson|J. C. Janson|
24 Novel Fluorescent Sensors for Diagnosis in Solid Tumor, 会议论文 徐玉芳|
25 Design, synthesis, and antitumor evaluation of novel acenaphtho[1,2-b]pyrrole-carboxylic acid esters with amino chain substitution 期刊论文 J. N. Cui|F. Y. Liu|G. Y. Li|X. H. Qian|R. Zhang|Y. Xiao|
26 Design, Synthesis and Properties of Some Novel Fluorophores 会议论文 肖义|
27 Exploring novel enzymes from insects 会议论文 杨青|
28 Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding 期刊论文 J. H. Li|Y. F. Xu|X. H. Qian|L. Y. Shen|J. W. Liu|Y. Liu|Y. X. Zhang|
29 Highly efficient antitumor agents of heterocycles containing sulfur atom: Linear and angular thiazonaphthalimides against human lung cancer cell in vitro 期刊论文 Q. Yang|Z. G. Li|X. H. Qian|
30 Highly sensitive and selective ratiometric fluorescent copper sensors: Different binding affinities modulated by three separate side chains of naphthalimide 期刊论文 F. Lu|T. Y. Cheng|Y. F. Xu|Z. C. Xu|X. H. Qian|
31 Novel BTH Analogues as Elicitors for Secondary Metabolites in Cell Culture and Soil-borne Disease control 会议论文 徐玉芳|
32 Green Chemistry of Pesticides and Dyes: Molecular Design and Structure- Property Relationship of Greener Insecticides and Fluorescent Sensors 会议论文 钱旭红|
33 Baker's yeast-mediated enantioselective reduction of substituted fluorenones 期刊论文 J. N. Cui|X. Y. Wang|W. M. Ren|F. Li|X. H. Qian|
34 Highly selective fluorescent chemosensor with red shift for cysteine in buffer solution and its bioimage: symmetrical naphthalimide aldehyde 期刊论文 J. W. Liu|T. Y. Cheng|L. P. Duan|Y. F. Xu|X. H. Qian|F. Wang|
35 Efficient Synthesis of Regioisomerically Pure Bis(trifluoromethyl)-Substituted 3,4,9,10-Perylene Tetracarboxylic Bis(benzimidazole) 期刊论文 Z. Y. Yuan|Y. Xiao|Z. Li|X. H. Qian|
36 A highly selective Cd2+ sensor of naphthyridine: fluorescent enhancement and red-shift by the synergistic action of forming binuclear complex 期刊论文 Y. Xiao|X. H. Qian|Y. Zhou|
37 Novel N-oxide of naphthalimides as prodrug leads against hypoxic solid tumor: Synthesis and biological evaluation 期刊论文 H. Yin|Y. F. Xu|H. W. Liu|X. H. Qian|Y. L. Li|
38 Micelle-induced versatile performance of amphiphilic intramolecular charge-transfer fluorescent molecular sensors 期刊论文 J. B. Wang|X. H. Qian|Y. F. Xu|J. H. Qian|
39 Highly sensitive and selective Pd2+ sensor of naphthalimide derivative based on complexation with alkynes and thio-heterocycle 期刊论文 X. H. Qian|L. P. Duan|Y. F. Xu|
40 Molecular logic operations based on surfactant nanoaggregates 期刊论文 X. H. Qian|J. H. Qian|S. Y. Zhang|Y. F. Xu|
41 Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease 期刊论文 Y. G. Li|Y. S. Sun|X. H. Qian|J. Q. Xu|Q. Yang|Z. G. Li|
42 Multiple molecular logic functions and molecular calculations facilitated by surfactant's versatility 期刊论文 J. H. Qian|S. Y. Zhang|X. H. Qian|Y. F. Xu|
43 A Gold(I) Phosphine Complex Containing a Naphthalimide Ligand Functions as a TrxR Inhibiting Antiproliferative Agent and Angiogenesis Inhibitor 期刊论文 Y. F. Xu|D. H. W. Vlecken|D. Kubutat|J. Will|A. Prokop|C. P. Bagowski|W. S. Sheldrick|I. J. Marques|I. Ott|X. H. Qian|P. Jesse|
44 Novel acenaphtho[1,2-b]pyrrole-carboxylic acid family: Synthesis, cytotoxicity, DNA-binding and cell cycle evaluation 期刊论文 L. J. Xie|J. N. Cui|X. H. Qian|Y. Xiao|R. Zhang|F. Wang|Y. F. Xu|J. W. Liu|
45 A colorimetric sensor for Cu2+ in aqueous solution based on metal ion-induced deprotonation: deprotonation/protonation mediated by Cu2+-ligand interactions 期刊论文 J. H. Huang|X. H. Qian|Y. F. Xu|
46 Fluorescent molecular sensors for heavy and transition metallic cations with biological interests 期刊论文 Y. F. Xu|X. H. Qian|W. P. Zhu|
47 Novel 4H-1,3,4-oxadiazin-5(6H)-ones with hydrophobic and long alkyl chains: Design, synthesis, and bioactive diversity on inhibition of monoamine oxidase, chitin biosynthesis and tumor cell 期刊论文 N. Wang|S. Y. Ke|X. H. Qian|Q. Yang|F. Y. Liu|Z. Li|
48 A Highly Sensitive and Selective OFF-ON Fluorescent Sensor for Cadmium in Aqueous Solution and Living Cell 期刊论文 W. P. Zhu|T. Y. Cheng|L. P. Duan|Y. F. Xu|S. Y. Zhang|X. H. Qian|
49 A novel beta-N-acetyl-D-hexosaminidase from the insect Ostrinia furnacalis (Guenee) 期刊论文 X. H. Qian|Q. Yang|F. Y. Liu|M. B. Qu|T. Liu|
50 Detecting Hg2+ ions with an ICT fluorescent sensor molecule: Remarkable emission spectra shift and unique selectivity 期刊论文 J. N. Cui|J. B. Wang|X. H. Qian|
51 Sulfur-substituted naphthalimides as photoactivatable anticancer agents: DNA interaction, fluorescence imaging, and phototoxic effects in cultured tumor cells 期刊论文 Y. F. Xu|J. W. Liu|W. S. Sheldrick|I. Ott|M. Kokoschka|M. Harlos|X. H. Qian|
52 Naphthalimide intercalators with chiral amino side chains: Effects of chirality on DNA binding, photodamage and antitumor cytotoxicity 期刊论文 Q. Yang|P. Yang|L. P. Tong|X. H. Qian|
53 Novel antitumor agent family of 1H-benzo[c,d]indol-2-one with flexible basic side chains: Synthesis and biological evaluation 期刊论文 X. H. Qian|Y. F. Xu|H. Yin|
54 Novel fluorescent fluorine-boron complexes: Synthesis, crystal structure, photoluminescence, and electrochemistry properties 期刊论文 X. H. Qian|Y. Xiao|Y. Zhou|D. Li|M. Y. Fu|
55 Effects of anionic surfactant SDS on the photophysical properties of two fluorescent molecular sensors 期刊论文 S. Y. Zhang|X. H. Qian|J. H. Qian|J. B. Wang|Y. F. Xu|
56 Novel naphthalimide derivatives as potential apoptosis-inducing agents: Design, synthesis and biological evaluation 期刊论文 X. H. Qian|A. B. Wu|Y. F. Xu|J. Wang|J. W. Liu|
57 Novel nitroheterocyclic hypoxic markers for solid tumor: Synthesis and biological evaluation 期刊论文 Y. F. Xu|M. Dai|W. P. Zhu|X. H. Qian|
58 Novel angular furoquinolinones bearing flexible chain as antitumor agent: Design, synthesis, cytotoxic evaluation, and DNA-binding studies 期刊论文 Y. Xiao|J. N. Cui|L. J. Xie|K. W. Wang|L. Y. Cong|X. H. Qian|P. C. Wu|
59 Long-wavelength boradiazaindacene derivatives with two-photon absorption activity and strong emission: versatile candidates for biological imaging applications 期刊论文 X. H. Qian|D. K. Zhang|S. X. Qian|Y. C. Wang|Y. Xiao|
60 Bulky 4-tritylphenylethynyl substituted boradiazaindacene: pure red emission, relatively large Stokes shift and inhibition of self-quenching 期刊论文 D. K. Zhang|Y. Q. Liu|X. H. Qian|G. Yu|Y. Xiao|Y. G. Wen|
61 Chromogenic and fluorescent chemodosimeter for fluoride ion based on novel anion-catalyzed intramolecular hydrogen transfer 期刊论文 Z. Li|C. X. Liu|X. H. Qian|G. Q. Sun|L. W. Zhao|
62 生物功能色素及荧光分子传感器 奖励 钱旭红,肖义,崔京南,徐玉芳|
63 Eliminating nucleic acids contaminants by hydrogen peroxide-induced free radicals during the preparation of proteins 期刊论文 J. Q. Xu|K. Zhang|X. Y. Lei|Q. Yang|X. H. Qian|
64 Novel naphthalimide-amino acid conjugates with flexible leucine moiety as side chain: Design, synthesis and potential antitumor activity 期刊论文 A. B. Wu|Y. F. Xu|X. H. Qian|
65 Selective and Sensitive Chromo- and Fluorogenic Dual Detection of Anionic Surfactants in Water Based on a Pair of "On-Off-On" Fluorescent Sensors 期刊论文 Y. F. Xu|J. H. Qian|X. H. Qian|
66 Chemical biotechnology and engineering: cell elicitors, artificial nucleases and fluorescent sensors of heterocycles 会议论文 钱旭红|
67 M-2-A induces apoptosis and G(2)-M arrest via inhibiting PI3 K/Akt pathway in HL60 cells 期刊论文 J. Wang|X. H. Qian|A. B. Wu|Y. F. Xu|J. W. Liu|
68 Novel Fluorescent Sensors for Diagnosis in Disease 会议论文 徐玉芳|
69 Exploiting the deprotonation mechanism for the design of ratiometric and colorimetric Zn2+ fluorescent chemosensor with a large red-shift in emission 期刊论文 R. Zhang|Z. C. Xu|X. H. Qian|J. A. Cui|
70 Novel cyanine dyes as fluorescent pH sensors: PET, ICT mechanism or resonance effect? 期刊论文 X. H. Qian|Y. Liu|Y. F. Xu|
71 Expression, purification and characterization of Gloydius shedaoensis venom gloshedobin as Hsp70 fusion protein in Pichia pastoris 期刊论文 Daping Yang, Mingli Peng, Hua Yang, Qing Yang, Jia|
72 Molecular design, chemical synthesis, and biological evaluation of '4-1' pentacyclic aryl/heteroaryl-imidazonaphthalimides 期刊论文 F. Li|X. H. Qian|L. Y. Guo|K. W. Wang|F. Y. Liu|J. N. Cui|W. M. Ren|
73 Synthesis of new amonafide analogues via coupling reaction and their cytotoxic evaluation and DNA-binding studies 期刊论文 X. H. Qian|J. N. Cui|L. J. Xie|Y. F. Xu|J. W. Liu|F. Wang|
74 Fluorescent Sensors with Non-sulfur and Non-cyclic Receptors in Aqueous Solution or Live Cells 会议论文 钱旭红|
75 A naphthalimide-calixarene as a two-faced and highly selective fluorescent chemosensor for Cu2+ or F 期刊论文 S. J. Han|C. Lee|J. S. Kim|J. Yoon|S. Kim|H. N. Kim|X. H. Qian|Z. Xu|
76 Expression, purification and characterization of the chitinolytic beta-N-acetyl-D-hexosaminidase from the insect Ostrinia furnacalis. Protein Expression and Purification, 期刊论文 Bo Xie, Jun Yang, Bo Xie, Jun Yang, Qing Yang, Wei|
77 Isoquino[4,5-bc]acridines: Design, synthesis and evaluation of DNA binding, anti-tumor and DNA photo-damaging ability 期刊论文 Q. Yang|L. P. Tong|X. H. Qian|X. L. Li|P. Yang|
78 Enantioselective reduction of fluorenones in surfactant-aqueous solution by fruits and vegetables 期刊论文 Bo Xie, Jun Yang, Qing Yang, Weiguang Yuan|
79 Selective and Sensitive Chromo- and Fluorogenic Dual Detection of Anionic Surfactants in Water Based on a Pair of "On-Off-On" Fluorescent Sensors 期刊论文 Y. F. Xu|J. H. Qian|X. H. Qian|
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