S100A8/A9调控TLR4信号通路在蛛网膜下腔出血后白质损伤中的作用及机制研究
81801176
2018
H0906.脑血管结构、功能异常及相关疾病
彭建华
青年科学基金项目
副教授
西南医科大学
21万元
蛛网膜下腔出血;小胶质细胞;Toll样受体4;白质损伤;神经炎症
2019-01-01到2021-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 颅内动脉瘤的相关信号通路基因集富集及免疫浸润分析 | 期刊论文 | 古龙;周牮;彭建华;庞金伟;谢雨珂;郭科成;张丽芳;陈礼刚;江涌 |
| 2 | Gut microbiota-brain interaction: An emerging immunotherapy for traumatic brain injury. | 期刊论文 | Zhang Yuxuan;Wang Zhaoyang;Peng Jianhua;Gerner Stefan T;Yin Shigang;Jiang Yong |
| 3 | The MC4 receptor agonist RO27-3225 inhibits NLRP1-dependent neuronal pyroptosis via the ASK1/JNK/p38 MAPK pathway in a mouse model of intracerebral haemorrhage. | 期刊论文 | Chen Shengpan;Zuo Yuchun;Huang Lei;Sherchan Prativa;Zhang Jian;Yu Zhengtao;Peng Jianhua;Zhang Junyi;Zhao Lianhua;Doycheva Desislava;Liu Fei;Zhang John H;Xia Ying;Tang Jiping |
| 4 | Nucleo-cytoplasmic RNA distribution responsible for maintaining neuroinflammatory microenvironment | 期刊论文 | Yuyan Liao;Chenghao Kuang;Zheng Bao;Yijing He;Long Gu;Qianke Tao;Xiancheng Qiu;Ghosh Dipritu;Xi Kong;Lifang Zhang;Jianhua Peng;Yong Jiang;Shigang Yin |
| 5 | Apolipoprotein E Deficiency Aggravates Neuronal Injury by Enhancing Neuroinflammation via the JNK/c-Jun Pathway in the Early Phase of Experimental Subarachnoid Hemorrhage in Mice | 期刊论文 | Yue Wu;Jinwei Pang;Jianhua Peng;Fang Cao;Zongduo Guo;Li Jiang;Zhipeng Teng;Zhijian Huang;Chongjie Cheng;Yong Jiang;Xiaochuan Sun |
| 6 | Irisin Contributes to Neuroprotection by Promoting Mitochondrial Biogenesis After Experimental Subarachnoid Hemorrhage | 期刊论文 | Tianqi Tu;Shigang Yin;Jinwei Pang;Xianhui Zhang;Lifang Zhang;Yuxuan Zhang;Yuke Xie;Kecheng Guo;Ligang Chen;Jianhua Peng;Yong Jiang |
| 7 | The Association Between Serum Macrophage Migration Inhibitory Factor and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage | 期刊论文 | Xiaobo Yang;Jianhua Peng;Jinwei Pang;Weifeng Wan;Chuanhong Zhong;Tangming Peng;Kunyang Bao;Yong Jiang |
| 8 | 双糖链蛋白聚糖对小鼠蛛网膜下腔出血后早期脑损伤中神经元凋亡的影响 | 期刊论文 | 谢雨珂;郭科成;彭建华;庞金伟;周牮;古龙;张丽芳;尹世刚;陈礼刚;江涌 |
| 9 | LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1/PI3K/Akt pathway after subarachnoid hemorrhage in rats | 期刊论文 | Jianhua Peng;Jinwei Pang;Lei Huang;Budbazar Enkhjargal;Tongyu Zhang;Jun Mo;Pei Wu;Weilin Xu;Yuchun Zuo;Jun Peng;Gang Zuo;Ligang Chen;Jiping Tang;John H. Zhang;Yong Jiang |
| 10 | 小鼠蛛网膜下腔出血后早期脑损伤期转运蛋白的表达 | 期刊论文 | 周牮;古龙;彭建华;庞金伟;谢雨珂;郭科成;张丽芳;张先辉;陈礼刚;江涌 |
| 11 | RNA-seq reveals underlying transcriptomic mechanisms of bone marrow-derived mesenchymal stem cells in the regulation of microglia-mediated neuroinflammation after subarachnoid hemorrhage | 期刊论文 | Lifang Zhang;Kecheng Guo;Shigang Yin;Jianhua Peng;Jinwei Pang;Ning Ma;Xianhui Zhang;Yuke Xie;Ligang Chen;Yong Jiang |
| 12 | FNDC5/Irisin: A New Protagonist in Acute Brain Injury | 期刊论文 | Tianqi Tu;Jianhua Peng;Yong Jiang |
| 13 | Biglycan regulates neuroinflammation by promoting M1 microglial activation in early brain injury after experimental subarachnoid hemorrhage | 期刊论文 | Yuke Xie;Jianhua Peng;Jinwei Pang;Kecheng Guo;Lifang Zhang;Shigang Yin;Jian Zhou;Long Gu;Tianqi Tu;Qiancheng Mu;Yuyan Liao;Xianhui Zhang;Ligang Chen;Yong Jiang |
| 14 | Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice | 期刊论文 | Jinwei Pang;Jianhua Peng;Nathanael Matei;Ping Yang;Li Kuai;Yue Wu;Ligang Chen;Michael P. Vitek;Fengqiao Li;Xiaochuan Sun;John H. Zhang;Yong Jiang |
| 15 | Association of Pericyte Loss With Microthrombosis After Subarachnoid Hemorrhage in ApoE-Deficient Mice | 期刊论文 | Jinwei Pang;Yue Wu;Jianhua Peng;Ping Yang;Ligang Chen;Yong Jiang |
| 16 | 蛛网膜下腔出血早期干预策略的基础与临床研究 | 奖励 | 江涌;孙晓川;刘爱华;陈礼刚;何朝晖;黄昌仁;郑思琳;郭宗铎;吴中学;彭汤明;庞金伟;彭建华;杨昌美 |
| 17 | 长链非编码RNA F19对小鼠创伤性脑损伤后继发性脑损伤的影响 | 期刊论文 | 彭建华;庞金伟;吴越;谢雨珂;郭科成;涂天琦;母前程;廖玉嫣;曹芳;刘亮;陈礼刚;孙晓川;江涌 |
| 18 | Transcriptomic Profiling Reveals the Antiapoptosis and Antioxidant Stress Effects of Fos in Ischemic Stroke. | 期刊论文 | Mu Qiancheng;Zhang Yuxuan;Gu Long;Gerner Stefan T;Qiu Xiancheng;Tao Qianke;Pang Jinwei;Dipritu Ghosh;Zhang Lifang;Yin Shigang;Jiang Yong;Peng Jianhua |
| 19 | Apolipoprotein E-Mimetic Peptide COG1410 Enhances Retinal Ganglion Cell Survival by Attenuating Inflammation and Apoptosis Following TONI | 期刊论文 | Li Kuai;Jianhua Peng;Yong Jiang;Zheng Zheng;Xiyuan Zhou |
| 20 | TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice | 期刊论文 | Shengpan Chen;Jianhua Peng;Prativa Sherchan;Yongjie Ma;Sishi Xiang;Feng Yan;Hao Zhao;Yong Jiang;Ning Wang;John H. Zhang;Hongqi Zhang |
| 21 | Ponesimod protects against neuronal death by suppressing the activation of A1 astrocytes in early brain injury after experimental subarachnoid hemorrhage. | 期刊论文 | Zhang Lifang;Guo Kecheng;Zhou Jian;Zhang Xianhui;Yin Shigang;Peng Jianhua;Liao Yuyan;Jiang Yong |
| 22 | White Matter Injury in Early Brain Injury after Subarachnoid Hemorrhage | 期刊论文 | Jinwei Pang;Jianhua Peng;Ping Yang;Li Kuai;Ligang Chen;John H. Zhang;Yong Jiang |
| 23 | TSPO ligand Ro5-4864 modulates microglia/macrophages polarization after subarachnoid hemorrhage in mice | 期刊论文 | Jian Zhou;Xianhui Zhang;Jianhua Peng;Yuke Xie;Fengling Du;Kecheng Guo;Yue Feng;Lifang Zhang;Ligang Chen;Yong Jiang |
| 24 | Single clip: An improvement of the filament-perforation mouse subarachnoid haemorrhage model | 期刊论文 | Jianhua Peng;Yue Wu;Jinwei Pang;Xiaochuan Sun;Ligang Chen;Yue Chen;Jiping Tang;John H. Zhang;Yong Jiang |
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