棕色脂肪组织脂代谢重塑的分子机制研究
92057110
2020
C1107.营养与代谢生理学
陈政
重大研究计划
研究员
哈尔滨工业大学
78万元
脂质代谢;棕色脂肪组织;脂质储存;出生后发育;温度-脂代谢重塑
2021-01-01到2023-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | “长江学者奖励计划”青年学者 | 奖励 | 陈政 |
| 2 | Hepatocyte-specific Wtap deficiency promotes hepatocellular carcinoma by activating GRB2–ERK depending on downregulation of proteasome-related genes | 期刊论文 | Xinzhi Li;Chunhong Liu;Zhimin Zhang;Xueying Li;Zhicheng Yao;Yanbin Dong;Xin Wang;Zheng Chen |
| 3 | Progress and Prospects of Non-Canonical NF-κB Signaling Pathway in the Regulation of Liver Diseases | 期刊论文 | Li Tao;Xiaomeng Ren;Wenhui Zhai;Zheng Chen |
| 4 | METTL3 is required for maintaining β-cell function. | 期刊论文 | Xinzhi Li;Yuze Jiang;Xu Sun;Yongsen Wu;Zheng Chen |
| 5 | Downregulation of the m6A reader protein YTHDC1 leads to islet β-cell failure and diabetes | 期刊论文 | Xinzhi Li;Ying Yang;Zheng Chen |
| 6 | The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression. | 期刊论文 | Xinzhi Li;Bingchuan Yuan;Min Lu;Yuqin Wang;Na Ding;Chunhong Liu;Ming Gao;Zhicheng Yao;Shiyan Zhang;Yujun Zhao;Liwei Xie;Zheng Chen |
| 7 | Downregulation of hepatic METTL3 contributes to APAP-induced liver injury in mice | 期刊论文 | Chunhong Liu;Xinzhi Li;Ming Gao;Yanbin Dong;Zheng Chen |
| 8 | Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling | 期刊论文 | Yu Qian;Zhengxiong Ma;Chunhong Liu;Xinzhi Li;Xinyan Zhu;Na Wang;Zhenmei Xu;Ruixue Xia;Jiale Liang;Yaning Duan;Han Yin;Yangjie Xiong;Anqi Zhang;Changyou Guo;Zheng Chen;Zhiwei Huang;Yuanzheng He |
| 9 | Hepatocyte-specific deletion of Mettl3 promotes hepatocellular carcinoma in mice | 期刊论文 | Chunhong Liu;Xinzhi Li;Zhicheng Yao;Xueying Li;Zheng Chen |
| 10 | Downregulation of Wtap causes dilated cardiomyopathy and heart failure | 期刊论文 | Lei Shi;Xinzhi Li;Meiwei Zhang;Cong Qin;Zhiguo Zhang;Zheng Chen |
| 11 | Identification of oleic acid as an endogenous ligand of GPR3 | 期刊论文 | Yangjie Xiong;Zhenmei Xu;Xinzhi Li;Yuqin Wang;Jing Zhao;Na Wang;Yaning Duan;Ruixue Xia;Zhengbin Han;Yu Qian;Jiale Liang;Anqi Zhang;Changyou Guo;Asuka Inoue;Yu Xia;Zheng Chen;Yuanzheng He |
| 12 | WTAP Regulates Postnatal Development of Brown Adipose Tissue by stabilizing METTL3 in mice | 期刊论文 | Yuqin Wang;Xinzhi Li;Cenxi Liu;Liying Zhou;Lei Shi;Zhiguo Zhang;Long Chen;Ming Gao;Lanyue Gao;Yuanyuan Xu;He Huang;Jin Li;Zheng Chen |
| 13 | Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice | 期刊论文 | Xinzhi Li;Ying Yang;Zhenzhi Li;Yuqin Wang;Jingting Qiao;Zheng Chen |
| 14 | Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH) | 期刊论文 | Xinzhi Li;Kaixin Ding;Xueying Li;Bingchuan Yuan;Yuqin Wang;Zhicheng Yao;Shuaikang Wang;He Huang;Bolin Xu;Liwei Xie;Tuo Deng;Xiao-wei Chen;Zheng Chen |
| 15 | GBP5 promotes liver injury and inflammation by inducing hepatocyte apoptosis | 期刊论文 | Kaixin Ding;Xinzhi Li;Xiaomeng Ren;Na Ding;Li Tao;Xue Dong;Zheng Chen |
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