Sirt3调控SFXN1去乙酰化促进一碳代谢重编程逆转胰腺癌恶性生物学行为的机制研究

81902803
2019
H1807.肿瘤代谢
蓝林华
青年科学基金项目
副研究员
温州医科大学
21万元
去乙酰化;胰腺癌;丝氨酸代谢;蛋白质质量控制;代谢重编程
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 6-methoxydihydroavicine, the alkaloid extracted from Macleaya cordata (Willd.) R. Br. (Papaveraceae), triggers RIPK1/Caspase-dependent cell death in pancreatic cancer cells through the disruption of oxaloacetic acid metabolism and accumulation of reactive oxygen species 期刊论文 Nengfang Ma;Fugen Shangguan;Hongfei Zhou;Huimin Huang;Jun Lei;Jing An;Guihua Jin;Weiwei Zhuang;Shipeng Zhou;Shijia Wu;Hongping Xia;Hailong Yang;Linhua Lan
2 Chlorogenic acid depresses cellular bioenergetics to suppress pancreatic carcinoma through modulating c-Myc-TFR1 axis 期刊论文 Yang Hongbao;Said Abdullahi Mohamed;Huang Huimin;Papa Akuetteh Percy David;Jin Guihua;Wu Shijia;Ma Nengfang;Lan Linhua;Shangguan Fugen;Zhang Qiyu
3 Dimethyl Fumarate Induces Metabolic Crisie to Suppress Pancreatic Carcinoma 期刊论文 Chen Kaiyuan;Wu Shanshan;Ye Sisi;Huang Huimin;Zhou Yi;Zhou Hongfei;Wu Shijia;Mao Yefan;Shangguan Fugen;Lan Linhua;Chen Bicheng
4 A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma 期刊论文 Shijia Wu;Yong Ai;Huimin Huang;Guangyu Wu;Shipeng Zhou;Weilong Hong;Percy David Papa Akuetteh;Guihua Jin;Xingling Zhao;Yihua Zhang;Xiaolong Zhang;Linhua Lan
5 Synthetic oleanane triterpenoid derivative CDDO‐Me disrupts cellular bioenergetics to suppress pancreatic ductal adenocarcinoma via targeting SLC1A5 期刊论文 Percy D. P. Akuetteh;Huimin Huang;Shijia Wu;Hongfei Zhou;Guihua Jin;Welong Hong;Hongbao Yang;Linhua Lan;Fugen Shangguan;Qiyu Zhang
6 Single-Cell Transcriptome Reveals the Metabolic and Clinical Features of a Highly Malignant Cell Subpopulation in Pancreatic Ductal Adenocarcinoma 期刊论文 Yangyang Fang;Shunjie Pei;Kaizhao Huang;Feng Xu;Guangxin Xian;Linhua Lan;Xiaoqun Zheng
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