MD2蛋白在肥胖诱导心肌损伤中的作用和机制研究
81503123
2015
H3507.代谢性疾病药物药理
张亚利
青年科学基金项目
副研究员
温州医科大学
19万元
髓样分化蛋白2;肥胖;炎症;凋亡;心肌损伤
2016-01-01到2018-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | 单羰基类化合物、组合物及在制备药物中的应用 | 专利 | 蔡跃飘;梁广;王哲;邹鹏;张亚利;唐琴琴 |
| 2 | Inhibition of myeloid differentiation factor-2 attenuates obesity-induced cardiomyopathy and fibrosis. | 期刊论文 | Fang Qilu;Wang Jingying;Zhang Yali;Wang Lintao;Li Weixin;Han Jibo;Huang Weijian;Liang Guang;Wang Yi |
| 3 | Targeting myeloid differentiation protein 2 (MD-2) by the new chalcone L2H21 protects LPS-induced acute lung injury | 期刊论文 | Yali Zhang;Tingting Xu;Beibei Wu;Hongjin Chen;Zheer Pan;Yi Huang;Liqin Mei;Yuanrong Dai;Xing Liu;Xiaoou Shan;Guang Liang |
| 4 | Blockade of myeloid differentiation protein 2 prevents obesity-induced inflammation and nephropathy | 期刊论文 | Fang Qilu;Lintao Wang;Daona Yang;Xiong Chen;Xiaoou Shan;Yali Zhang;Hazel Lum;Jingying Wang;Peng Zhong;Guang Liang;Yi Wang |
| 5 | Discovery of a new inhibitor of myeloid differentiation 2 from cinnamamide derivatives with anti-inflammatory activity in sepsis and acute lung injury | 期刊论文 | Gaozhi Chen;Yali Zhang;Xing Liu;Qilu Fang;Zhe Wang;Lili Fu;Zhiguo Liu;Yi Wang;Yunjie Zhao;Xiaokun Li;Guang Liang |
| 6 | Shikonin inhibits myeloid differentiation protein-2 to prevent lipopolysaccharide-induced acute lung injury | 期刊论文 | Yali Zhang;Tingting Xu;Zheer Pan;Xiangting Ge;Chuchu Sun;Chun Lu;Hongjin Chen;Zhongxiang Xiao;Bing Zhang;Yuanrong Dai;Guang Liang |
| 7 | 含硝基的姜黄素衍生物及其制备方法与应用 | 专利 | 梁广;张亚利;刘志国;冯建鹏;陈文波;俞鹏天 |
| 8 | Discovery of new MD2 inhibitor from chalcone derivatives with anti-inflammatory effects in LPS-induced acute lung injury | 期刊论文 | Zhang Yali;Wu Jianzhang;Ying Shilong;Chen Gaozhi;Liu Zhiguo;Liu Xing;Huang Lehao;Liang Guang;Wu Beibei;Xu Tingting;Shan Xiaoou;Dai Yuanrong;Liang G |
| 9 | Saturated palmitic acid induces myocardial inflammatory injuries through direct binding to TLR4 accessory protein MD2 | 期刊论文 | Wang Yi;Qian Yuanyuan;Fang Qilu;Zhong Peng;Li Weixin;Wang Lintao;Fu Weitao;Zhang Yali;Xu Zheng;Li Xiaokun;Liang Guang |
| 10 | Inhibition of MD2-dependent inflammation attenuates the progression of non-alcoholic fatty liver disease | 期刊论文 | Yali Zhang;Beibei Wu;Hailing Zhang;Xiangting Ge;Shilong Ying;Mengwei Hu;Weixin Li;Yi Huang;Li Wang;Chao Chen;Xiaoou Shan;Guang Liang |
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