基于靶酶OfHex1的抑制剂分子设计合成与活性研究

21772230
2017
B0706.药物化学生物学
张建军
面上项目
教授
中国农业大学
64万元
OfHex1;生物活性;农药分子设计合成;酶抑制剂;定量构效关系
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Synthesis and Insecticidal activity of Homoenylmectin benzoate. 会议论文 Qingbo Xu;Jinming Li;Shuhui Jin;Jianjun Zhang
2 Identification of Novel Nematode SDH Inhibitors: Virtual Screening Based on Ligand-Pocket Interactions. 期刊论文 Qingbo Xu;Zhixiang Zhao;Peibo Liang;Simin Wang;Fang Li;Shuhui Jin;Jianjun Zhang
3 含糖基萘酰亚胺类荧光探针及其应用 专利 张建军;董利利;沈生强;路慧哲;金淑惠;王道全
4 含吡啶酰胺的胍基类衍生物及其制备方法与应用 专利 张建军;梁培博;金淑惠;路慧哲;董燕红
5 Design, Synthesis and Bioactivity of Fluopyram Derivatives Containing Diamide Moiety 期刊论文 Xu Qingbo;Liang Peibo;Lu Huizhe;Jin Shuhui;Dong Yanhong;Zhang Jianjun
6 一种双酰胺类化合物及其制备方法与应用 专利 张建军;许庆博;沈生强;金淑惠
7 Design and synthesis of naphthalimide group-bearing thioglycosides as novel beta-N-acetylhexosaminidases inhibitors 期刊论文 Shen Shengqiang;Chen Wei;Dong Lili;Yang Qing;Lu Huizhe;Zhang Jianjun
8 Succinate dehydrogenase; Antifungal activity; Nematicide; Molecular docking; Fluopyram 会议论文 Peibo Liang;Qingbo Xu;Shuhui Jin;Yanhong Dong;Jianjun Zhang
9 Computational Studies on the Potency and Selectivity of PUGNAc Derivatives Against GH3, GH20, and GH84 beta-N-acetyl-D-hexosaminidases 期刊论文 Dong Lili;Shen Shengqiang;Xu Yefei;Wang Leng;Feng Ruirui;Zhang Jianjun;Lu Huizhe
10 High Efficiency Synthesis of the Tetrasccharide Repeating Unit in Azospirillum brasilense Strains Sp246 Based on Silica Gel Supported Perchloric Acid (HClO4-SiO2) 期刊论文 Chen Zili;Li Peixia;Liu Weitong;Zhuang Zhe;Wu Yuanyuan;Zhao Hanqing;Zhang Jianjun
11 Development of sodium glucose co-transporter 2 (SGLT2) inhibitors with novel structure by molecular docking and dynamics simulation 期刊论文 Feng Ruirui;Dong Lili;Wang Leng;Xu Yefei;Lu Huizhe;Zhang Jianjun
12 阿维菌素B2a衍生物及其制备方法与应用 专利 张建军;许庆博;李金明;张江波
13 Novel tioglycoside OfHex1 inhibitors as green insect growth regulators (IGRs). 会议论文 Peibo Liang;Zhiqiang Zha;Fang Li;Qing Yang;Jianjun Zhang
14 Design and Optimization of Thioglycosyl-naphthalimides as Efficient Inhibitors Against Human O-GlcNAcase 期刊论文 Shen Shengqiang;Dong Lili;Chen Wei;Wu Renjie;Lu Huizhe;Yang Qing;Zhang Jianjun
15 Synthesis and Insecticidal Activity of 4 ''-Avermectin Triazole Derivatives Containing Amide Unit 期刊论文 Sun Guoshao;Zhang Jingjing;Jin Shuhui;Zhang Jianjun
16 Molecular Design and Biological Activity of Novel hexosaminidases Inhibitors 会议论文 Jianjun Zhang
17 阿维菌素B2a衍生物及其制备方法与应用. 专利 张建军;许庆博;李金明;张江波
18 Design, synthesis biological activity, and docking of novel fluopyram derivatives containing guanidine group 期刊论文 Liang Peibo;Shen Shengqiang;Xu Qingbo;Wang Simin;Jin Shuhui;Lu Huizhe;Dong Yanhong;Zhang Jianjun
19 Synthesis and Enzyme Substrate Activity of p-Nitrophenyl N,N'-Diacetyl-4-thio-beta-chitobioside 期刊论文 Guo Bingbo;Shen Shengqiang;Jin Shuhui;Lu Huizhe;Zhang Jianjun
20 Modification of the Thioglycosyl-Naphthalimides as Potent and Selective Human O-GlcNAcase Inhibitors 期刊论文 Shen Shengqiang;Dong Lili;Chen Wei;Zeng Xiangdi;Lu Huizhe;Yang Qing;Zhang Jianjun
21 Efficient synthesis of a 6-deoxy-talose containing tetrasccharide found in Franconibacter helveticus LMG23732(T) 期刊论文 Xu Yiren;Xu Tianheng;Zhang Jianjun
22 Synthesis, Optimization, and Evaluation of Glycosylated Naphthalimide Derivatives as Efficient and Selective Insect beta-N-Acetylhexosaminidase OfHex1 Inhibitors 期刊论文 Shen Shengqiang;Dong Lili;Chen Wei;Wu Renjie;Lu Huizhe;Yang Qing;Zhang Jianjun
23 Novel Glycosylated Naphthalimide-Based Activatable Fluorescent Probe: A Tool for the Assessment of Hexosaminidase Activity and Intracellular Hexosaminidase Imaging 期刊论文 Dong Lili;Shen Shengqiang;Lu Huizhe;Jin Shuhui;Zhang Jianjun
24 Selective inhibition of beta-N-acetylhexosaminidases by thioglycosyl-naphthalimide hybrid molecules 期刊论文 Chen Wei;Shen Shengqiang;Dong Lili;Zhang Jianjun;Yang Qing
25 Design,Synthesis and Bio activity of Naphthalimide Thioglycoside Derivatives as Novel β-N-Acetylhexosaminidase Inhibitors. 会议论文 Zhixiang Zhao;Fang Li;Wei Chen;Qing Yang;Huishe Lu;JianJun Zhang
26 Based molecular docking and molecular dynamics simulations to study OfHex1 selective inhibitors 会议论文 Lili Dong;Huizhe Lu;Jianjun Zhang
27 Synthesis of ureido thioglycosides as novel insect beta-N-acetylhexosaminidase OfHex1 inhibitors 期刊论文 Shen Shengqiang;Dong Lili;Lu Huizhe;Dong Yanhong;Yang Qing;Zhang Jianjun
28 Synthesis of the repeating unit of O-specific polysaccharide isolated from the water-borne bacteria Aeromonas bestiarum 207 期刊论文 Xu Yiren;Zong Guanghui;Jin Shuhui;Zhang Jianjun
29 Synthesis and insecticidal activities of 5-deoxyavermectin B2a oxime ester derivatives 期刊论文 Sun Guoshao;Zhang Jingjing;Jin Shuhui;Zhang Jianjun
30 Unravelling the binding affinity between model transport protein and a prospective tuberculosis therapeutic agent: a spectroscopic and theoretical simulation exploration 期刊论文 Wang Leng;Zhang Li;Feng Rui Rui;Dong Xue;Lu Hui Zhe;Zhang Jian Jun
31 一种甲基胍基脲衍生物及其制备方法与应用. 专利 张建军;赵志祥
32 Identification of novel insect beta-N-acetylhexosaminidase OfHex1 inhibitors based on virtual screening, biological evaluation, and molecular dynamics simulation 期刊论文 Dong Lili;Shen Shengqiang;Xu Yefei;Wang Leng;Yang Qing;Zhang Jianjun;Lu Huizhe
33 Glycosyl triazoles as novel insect beta-N-acetylhexosaminidase OfHex1 inhibitors: Design, synthesis, molecular docking and MD simulations 期刊论文 Dong Lili;Shen Shengqiang;Chen Wei;Lu Huizhe;Xu Dongdong;Jin Shuhui;Yang Qing;Zhang Jianjun
34 Exploring thioglycosyl–naphthalimides as novel inhibitors against OfHex1. 会议论文 Shengqiang Shen;Jianjun Zhang
35 Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation 期刊论文 Dong Lili;Shen Shengqiang;Chen Wei;Xu Dongdong;Yang Qing;Lu Huizhe;Zhang Jianjun
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