一锅多酶体系催化C-H键胺化新途径的从头构建

21672063
2016
B0705.生物合成化学
郁惠蕾
面上项目
教授
华东理工大学
65万元
多酶催化;生物催化;手性胺;级联反应
2017-01-01到2020-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 油酸水合酶及其在10-羟基硬脂酸与10-羰基硬脂酸合成中的应用 专利 许建和;吴艳霞;潘江;郁惠蕾;孙启帆;钱小龙
2 Enhancing the Catalytic Performance of a CYP116B Monooxygenase by Transdomain Combination Mutagenesis 期刊论文 Li Ren-Jie;Xu Jian-He;Chen Qi;Zhao Jing;Li Ai-Tao;Yu Hui-Lei
3 Engineering of Cyclohexanone Monooxygenase for the Enantioselective Synthesis of (S)-Omeprazole 期刊论文 Zhang Yan;Wu Yin-Qi;Xu Na;Zhao Qian;Yu Hui-Lei;Xu Jian-He
4 Enantioselective Bioamination of Aromatic Alkanes Using Ammonia: A Multienzymatic Cascade Approach 期刊论文 Wang Hui;Zheng Yu-Cong;Chen Fei-Fei;Xu Jian-He;Yu Hui-Lei
5 Regioselectivity Engineering of Epoxide Hydrolase: Near-Perfect Enantioconvergence through a Single Site Mutation 期刊论文 Li Fu-Long;Kong Xu-Dong;Chen Qi;Zheng Yu-Cong;Xu Qin;Chen Fei-Fei;Fan Li-Qiang;Lin Guo-Qiang;Zhou Jiahai;Yu Hui-Lei;Xu Jian-He
6 Protein termini relocation plus random mutation: A new strategy for finding key sites in esterase evolution 期刊论文 Qi Yi-Ke;Li Fu-Long;Chen Qi;Zhang Zhi-Jun;Luan Zheng-Jiao;Xu Jian-He;Yu Hui-Lei
7 一种羰基还原酶突变体及其基因与应用 专利 张志钧;郁惠蕾;李敏;许建和;潘江
8 生物催化剂的快速定制改造及高效合成手性化学品的关键技术 奖励 许建和;郑高伟;郁惠蕾;钱祥云;李春秀;白云鹏;潘江;张志钧;陈琦
9 底物亲和力和辅酶亲和力提高的甲酸脱氢酶突变体 专利 郑高伟;江和文;陈琦;郁惠蕾;潘江;许建和;钱小龙
10 大数据时代工业酶的发掘、改造和利用 期刊论文 郁惠蕾;张志钧;李春秀;钱小龙;郭飞;许建和
11 Engineering P450(LaMO) stereospecificity and product selectivity for selective C-H oxidation of tetralin-like alkylbenzenes 期刊论文 Li Ren-Jie;Li Aitao;Zhao Jing;Chen Qi;Li Ning;Yu Hui-Lei;Xu Jian-He
12 医药化学品的绿色生物制造 期刊论文 张志钧;郁惠蕾;许建和
13 Rapid probing of the reactivity of P450 monooxygenases from the CYP116B subfamily using a substrate-based method 期刊论文 Li Ren-Jie;Xu Jian-He;Yin Yue-Cai;Wirth Nicolas;Ren Jiang-Meng;Zeng Bu-Bing;Yu Hui-Lei
14 Engineering Bacillus subtilis Isoleucine Dioxygenase for Efficient Synthesis of (2S,3R,4S)-4-Hydroxyisoleucine 期刊论文 Du Ping;Yan Shuai;Qian Xiao-Long;Pan Jiang;Zhang Zhi-Jun;Yu Hui-Lei;Xu Jian-He
15 异亮氨酸双加氧酶、突变体及在合成4-羟基异亮氨酸中的应用 专利 张志钧;钱小龙;杜平;郁惠蕾;许建和;潘江
16 Efficient Synthesis of (R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol with a Ketoreductase from Scheffersomyces stipitis CBS 6045 期刊论文 Shang Yue-Peng;Chen Qi;Kong Xu-Dong;Zhang Yu-Jun;Xu Jian-He;Yu Hui-Lei
17 环氧水解酶突变体及其在对映归一水解环氧化物中的应用 专利 郁惠蕾;李付龙;许建和;陈琦;潘江
18 CYP116B家族单加氧酶的发现、表征及分子改造研究进展 期刊论文 李仁结;张龑;许建和;郁惠蕾
19 Identification two key residues at the intersection of domains of a thioether monooxygenase for improving its sulfoxidation performance 期刊论文 Ren Shi-Miao;Liu Feng;Wu Yin-Qi;Chen Qi;Zhang Zhi-jun;Yu Hui-Lei;Xu Jian-He
20 Discovery of Two Native Baeyer-Villiger Monooxygenases for Asymmetric Synthesis of Bulky Chiral Sulfoxides 期刊论文 Zhang Yan;Liu Feng;Xu Na;Wu Yin-Qi;Zheng Yu-Cong;Zhao Qian;Lin Guoqiang;Yu Hui-Lei;Xu Jian-He
21 Bioamination of alkane with ammonium by an artificially designed multienzyme cascade 期刊论文 Yu Hui-Lei;Li Tuo;Chen Fei-Fei;Luo Xiao-Jing;Li Aitao;Yang Chao;Zheng Gao-Wei;Xu Jian-He
22 A 3D-QSAR assisted activity prediction strategy for expanding substrate spectra of an aldehyde ketone reductase 期刊论文 Cheng Qiang;Chen Qi;Xu Jian-He;Yu Hui-Lei
23 四氢噻吩-3-酮还原酶的筛选与表征 期刊论文 严阳;郁惠蕾;潘江;许建和
24 Reprogramming Epoxide Hydrolase to Improve Enantioconvergence in Hydrolysis of Styrene Oxide Scaffolds 期刊论文 Li Fu-Long;Qiu Yan-Yan;Zheng Yu-Cong;Chen Fei-Fei;Kong Xu-Dong;Xu Jian-He;Yu Hui-Lei
25 One Pot Asymmetric Synthesis of (R)-Phenylglycinol from Racemic Styrene Oxide via Cascade Biocatalysis 期刊论文 Sun Zai-Bao;Zhang Zhi-Jun;Li Fu-Long;Nie Yao;Yu Hui-Lei;Xu Jian-He
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