小胶质细胞TLR4/MyD88/NF-κB通路在睡眠碎片化导致POCD的机制研究

81760208
2017
H0902.意识障碍与认知功能障碍
徐国海
地区科学基金项目
主任医师
南昌大学
34万元
睡眠碎片化;术后认知功能障碍;中枢炎症;TLR4;小胶质细胞
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Sleep Deprivation Induces Cognitive Impairment by Increasing Blood-Brain Barrier Permeability via CD44 期刊论文 Sun Jing;Wu Jusheng;Hua Fuzhou;Chen Yong;Zhan Fenfang;Xu Guohai
2 Whole transcriptome sequencing reveals dexmedetomidine-improves postoperative cognitive dysfunction in rats via modulating lncRNA 期刊论文 Deng Fumou;Cai Lily;Zhou Bin;Zhou Zhidong;Xu GuoHai
3 IL-36细胞因子及其免疫作用的研究进展 期刊论文 詹芬芳;徐国海
4 Dexmedetomidine Mitigated NLRP3-Mediated Neuroinflammation via the Ubiquitin-Autophagy Pathway to Improve Perioperative Neurocognitive Disorder in Mice 期刊论文 Zhang Lieliang;Xiao Fan;Zhang Jing;Wang Xifeng;Ying Jun;Wei Gen;Chen Shoulin;Huang Xiangfei;Yu Wen;Liu Xing;Zheng Qingcui;Xu Guohai;Yu Shuchun;Hua Fuzhou
5 LncRNA 4344 promotes NLRP3-related neuroinflammation and cognitive impairment by targeting miR-138-5p 期刊论文 Feng Xiaojin;Zhan Fenfang;Luo Deqiang;Hu Jialing;Wei Gen;Hua Fuzhou;Xu Guohai
6 Non-coding RNAs: The key regulators in NLRP3 inflammasome-mediated inflammatory diseases 期刊论文 Feng Xiaojin;Luo Deqiang;Wei Gen;Zhan Fenfang;Hua Fuzhou;Xu Guohai
7 MicroRNA-138-5p Regulates Hippocampal Neuroinflammation and Cognitive Impairment by NLRP3/Caspase-1 Signaling Pathway in Rats 期刊论文 Feng Xiaojin;Hu Jialing;Zhan Fenfang;Luo Deqiang;Hua Fuzhou;Xu Guohai
8 Dexmedetomidine attenuates cisplatin-induced cognitive impairment by modulating miR-429-3p expression in rats 期刊论文 Li Chang;Niu Jiangfeng;Zhou Bin;Deng Wei;Deng Fumou;Zhou Zhidong;Xu Guohai
9 Piezo1 channels as force sensors in mechanical force-related chronic inflammation 期刊论文 Hailin liu;Jialing Hu;Qingcui Zheng;Xiaojin Feng;Fenfang Zhan;Xifeng Wang;Guohai Xu;Fuzhou Hua
10 雷公藤甲素对血管性痴呆大鼠认知功能的影响及对SIRT1/NF-κB信号通路的作用 期刊论文 姚鹏;陈勇;徐国海
11 Differential Expression of the TLR4 Gene in Pan-Cancer and Its Related Mechanism 期刊论文 Hu Jialing;Xu Jiasheng;Feng Xiaojin;Li Yiran;Hua Fuzhou;Xu Guohai
12 LncRNA-mRNA Expression Profiles and Functional Networks Associated with Cognitive Impairment in Folate-deficient Mice. 期刊论文 Xiaojin Feng;Fenfang Zhan;Jialing Hu;Fuzhou Hua;Guohai Xu
13 睡眠碎片化对围术期神经认知障碍影响的研究进展 期刊论文 詹芬芳;徐国海
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