CXCL12/CXCR4/MAPK信号传导通路在CB2受体激动剂调节癌痛吗啡耐受中的作用和机制研究

81771198
2017
H0903.感觉障碍、疼痛与镇痛
王国年
面上项目
教授
哈尔滨医科大学
54万元
癌痛;吗啡耐受;趋化因子;大麻素受体2
2018-01-01到2021-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Involvement of TCF7L2 in generation of morphine-induced antinociceptive tolerance and hyperalgesia by modulating TLR4/ NF-kappa B/NLRP3 in microglia 期刊论文 Chen Jing;Wang Guonian;Sun Tingting;Ma Chao;Huo Xing;Kong Yiran
2 Upregulation of mu-Opioid Receptor in the Rat Spinal Cord Contributes to the alpha 2-Adrenoceptor Agonist Dexmedetomidine-Induced Attenuation of Chronic Morphine Tolerance in Cancer Pain 期刊论文 Zhang Pinyi;Bu Jianlong;Wu Xiaohong;Deng Lin;Chi Meng;Ma Chao;Shi Xiaoding;Wang Guonian
3 Identification of Potential Long Non-coding RNA Expression Quantitative Trait Methylations in Lung Adenocarcinoma and Lung Squamous Carcinoma 期刊论文 Wu Xiaohong;Gao Yue;Bu Jianlong;Deng Lin;Zhang Pinyi;Chi Meng;Jiang Lihua;Shi Xiaoding;Ning Shangwei;Wang Guonian
4 Low-dose cannabinoid receptor 2 agonist induces microglial activation in a cancer pain-morphine tolerance rat model 期刊论文 Ma Chao;Zhang Mingyue;Liu Li;Zhang Pinyi;Liu Dandan;Zheng Xiaoyu;Zhong Xuelai;Wang Guonian
5 Lidocaine Alleviates Neuropathic Pain and Neuroinflammation by Inhibiting HMGB1 Expression to Mediate MIP-1 alpha/CCR1 Pathway 期刊论文 Li Mingming;Jiang Hao;Gu Kuo;Sun Xuechao;Gu Jing;Li Chunming;Wang Guonian
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