星型胶质细胞上调基因-1（AEG-1）在肌萎缩侧索硬化（ALS）星型胶质细胞中的作用及其相关机制研究

81571227
2015
H0912.神经退行性变及相关疾病
丰宏林
面上项目
教授
哈尔滨医科大学
57万元
星型胶质细胞;星型胶质细胞上调基因-1;肌萎缩侧索硬化
2016-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Lithium facilitates removal of misfolded proteins and attenuated faulty interaction between mutant SOD1 and p-CREB (Ser133) through enhanced autophagy in mutant hSOD1(G93A) transfected neuronal cell lines 期刊论文 Yin Xiang;Wang Shuyu;Wang Xudong;Yang Yueqing;Jiang Hongquan;Wang Tianhang;Wang Ying;Zhang Chunting;Feng Honglin
2 Downregulation of Homer1b/c in SOD1 G93A Models of ALS: A Novel Mechanism of Neuroprotective Effect of Lithium and Valproic Acid 期刊论文 Jiang H. Z.;Wang S. Y.;Yin X.;Jiang H. Q.;Wang X. D.;Wang J.;Wang T. H.;Qi Y.;Yang Y. Q.;Wang Y.;Zhang C. T.;Feng H. L.
3 Neuroprotection by urate on the mutant hSOD1-related cellular and Drosophila models of amyotrophic lateral sclerosis: Implication for GSH synthesis via activating Akt/GSK3beta/Nrf2/GCLC pathways. 期刊论文 Zhang Chunting;Yang Yueqing;Liang Weiwei;Wang Tianhang;Wang Shuyu;Wang Xudong;Wang Ying;Jiang Hongquan;Feng Honglin
4 Fisetin Exerts Antioxidant and Neuroprotective Effects in Multiple Mutant hSOD1 Models of Amyotrophic Lateral Sclerosis by Activating ERK 期刊论文 Wang T. H.;Wang S. Y.;Wang X. D.;Jiang H. Q.;Yang Y. Q.;Wang Y.;Cheng J. L.;Zhang C. T.;Liang W. W.;Feng H. L.
5 Spy1, a unique cell cycle regulator, alters viability in ALS motor neurons and cell lines in response to mutant SOD1-induced DNA damage 期刊论文 Wang Xu Dong;Zhu Min Wei;Shan Dan;Wang Shu Yu;Yin Xiang;Yang Yue Qing;Wang Tian Hang;Zhang Chun Ting;Wang Ying;Liang Wei Wei;Zhang Jun;Jiang Hai Zhi;Dong Guang Tao;Jiang Hong Quan;Qi Yan;Feng Hong Lin
6 Astrocyte elevated gene-1 is a novel regulator of astrogliosis and excitatory amino acid transporter-2 via interplaying with nuclear factor-kappaB signaling in astrocytes from amyotrophic lateral sclerosis mouse model with hSOD1(G93A) mutation 期刊论文 Yin X.;Wang S.;Qi Y.;Wang X.;Jiang H.;Wang T.;Yang Y.;Wang Y.;Zhang C.;Feng H.
7 alpha-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis 期刊论文 Wang T.;Cheng J.;Wang S.;Wang X.;Jiang H.;Yang Y.;Wang Y.;Zhang C.;Liang W.;Feng H.
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