【81130049】能量过剩与维生素D、钙缺乏并存对肥胖、2型糖尿病的影响及膳食干预研究国家自然基金项目

能量过剩与维生素D、钙缺乏并存对肥胖、2型糖尿病的影响及膳食干预研究

项目批准号： 81130049

批准年份： 2011

学科分类： H30.预防医学

项目负责人：孙长颢

资助类别：重点项目

负责人职称：教授

依托单位：哈尔滨医科大学

资助金额： 260万元

关键词：肥胖;维生素;2型糖尿病;矿物质;能量摄入过剩

起止时间： 2012-01-01到2016-12-31

中英文摘要
结题摘要
结题报告
项目成果
项目参与人

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序号	标题	类型	作者
1	BMI is Strongly Associated With Hypertension, and Waist Circumference is Strongly Associated With Type 2 Diabetes and Dyslipidemia, in Northern Chinese Adults	期刊论文	Fuchuan Guo\|Songtao Li\|Changhao Sun\|Ying Li\|
2	Increase of circulating cholesterol in vitamin D deficiency is linked to reduced vitamin D receptor activity via the Insig-2/SREBP-2 pathway	期刊论文	Lixin Na\|Yanwen Wang\|Ying Li\|Changhao Sun\|
3	Elevated circulating stearic acid leads to a major lipotoxic effect on mouse pancreatic beta cells in hyperlipidaemia via a miR-34a-5p-mediated PERK/p53-dependent pathway	期刊论文	Tianqi Zi\|Xia Chu\|Lixin Na\|Changhao Sun\|
4	Histidine supplementation alleviates inflammation in the adipose tissue of high-fat diet-induced obese rats via the NF-kB- and PPARg-involved pathways	期刊论文	Wei Zhang\|Ying Li\|Changhao Sun\|Songtao Li\|
5	Histidine and arginine are associated with inflammation and oxidative stress in obese women	期刊论文	Zhen Kang\|Jian Wang\|Ying Li\|Changhao Sun\|
6	Allosteric regulation of the calcium-sensing receptor in obese individuals	期刊论文	Hui Sun\|Tiantian Zhao\|Ying Li\|Changhao Sun\|
7	Calcium supplementation increases circulating cholesterol by reducing its catabolism via GPER and TRPC1-dependent pathway in estrogen deficient women	期刊论文	Cheng Wang\|Yanwen Wang\|Yonghan He\|Changhao Sun\|
8	Biomarkers identified by urinary metabonomics for noninvasive diagnosis and pathophysiology changes characterization of rickets	期刊论文	Tingting Liu\|Liqun Lin\|Ying Li\|Changhao Sun\|
9	糖尿病代谢组学及营养干预研究	奖励	孙长颢\|
10	Changes in triglycerides and high-density lipoprotein cholesterol may precede peripheral insulin resistance, with 2-h insulin partially mediating this unidirectional relationship: a prospective cohort study	期刊论文	Xi Liang\|Wei Duan\|Lixin Na\|Changhao Sun\|
11	Effects of the calcium-sensing receptor A986S polymorphism on serum calcium and parathyroid hormone levels in healthy individuals: A meta-analysis	期刊论文	Ying He\|Mingxin Bi\|Ying Li\|Changhao Sun\|
12	钙与肥胖关系研究	奖励	李颖\|
13	Increased Hemoglobin A1c Threshold for Prediabetes Remarkably Improving the Agreement Between A1c and Oral Glucose Tolerance Test Criteria in Obese Population	期刊论文	Wei Zhang\|Guanqiong Na\|Ying Li\|Changhao Sun\|
14	Maternal vitamin D deficiency during pregnancy results in insulin resistance in the rat off spring which is associated with inflammation and Iκbα methylation	期刊论文	Gang Li\|Yuxia Wang\|Ying Li\|Changhao Sun\|
15	Fasting Serum Lipid and Dehydroepiandrosterone Sulfate as Important Metabolites for Detecting Isolated Post-challenge Diabetes: Serum metabolomics using UPLC/MS	期刊论文	Lixin Na\|Yucun Niu\|Ying Li\|Changhao Sun\|
16	Lean-non-alcoholic fatty liver disease increases risk for metabolic disorders in a normal weight Chinese population	期刊论文	Yanchuan Li\|Liyan Liu\|Fuchuan Guo\|Changhao Sun\|
17	Lipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological study	期刊论文	Hua Ning\|Lima A\|Ying Li\|Changhao Sun\|
18	Targeted metabolomic analysis reveals the association between the postprandial change in palmitic acid, branched-chain amino acids and insulin resistance in young obese subjects	期刊论文	Fuchuang Guo\|Ying Li\|Jundong Jiao\|Changhao Sun\|
19	Histidine supplementation improves insulin resistance through suppressed inflammation in obese women with the metabolic syndrome: a randomised controlled trial	期刊论文	Can Zhao\|Fuchuan Guo\|Changhao Sun\|Ying Li\|
20	Association between vitamin D receptor gene polymorphism (TaqI) and obesity in Chinese population	期刊论文	Liqun Lin\|Hao Ma\|Ying Li\|Changhao Sun\|
21	The calcium-sensing receptor promotes adipocyte differentiation and adipogenesis through PPARγ pathway	期刊论文	Liang Wang\|Mingjie Tian\|Ying Li\|Changhao Sun\|
22	The harbin cohort study on diet, nutrition and chronic non-communicable diseases: study design and baseline characteristics	期刊论文	Li Lan\|Chao Yang\|Ying Li\|Changhao Sun\|
23	Sterol Regulatory Element–Binding Protein-1c Mediates Increase of Postprandial Stearic Acid, Potential Target for Improving Insulin Resistance, in Hyperlipidemia	期刊论文	Huimin Lu\|Songtao Li\|Ying Li\|Changhao Sun\|
24	Long-term calcium supplementation may have adverse effect on serum cholesterol and carotid intima-media thickness in postmenopausal women: a double-blind,randomized,placebo-ontrolled trial	期刊论文	Feifei Yuan\|Yucun Niu\|Yue Zhao\|Changhao Sun\|
25	The calcium-sensing receptor R990G polymorphismis associated with increased risk of hypertriglyceridemia in obese Chinese	期刊论文	Lixin Na\|Maoqing Wang\|Ben Perry\|Ying Li\|
26	High carbohydrate intake from starchy foods is positively associated with metabolic disorders: a Cohort Study from a Chinese population	期刊论文	Wei Zhang\|Guanqiong Na\|Ying Li\|Changhao Sun\|
27	Calcium-deficiency assessment and biomarker identification by an integrated urinary metabonomics analysis	期刊论文	Qiuju Zhang\|Lijun Fan\|Ying Li\|Changhao Sun\|
28	Vitamin D status and its association with adiposity and oxidative stress in school children	期刊论文	Xiaoxia Li\|Yonghan He\|Xuan He\|Changhao Sun\|

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