GPR15/GRK5/β-arrestin信号轴调节T细胞活化在急性移植物抗宿主病发生中的作用研究
81871263
2018
H1105.器官移植与移植免疫
徐开林
面上项目
教授
徐州医科大学
57万元
T细胞活化;靶向治疗;急性移植物抗宿主病;G蛋白偶联受体
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Impact of glucocorticoids on short-term and long-term outcomes in patients with relapsed/refractory multiple myeloma treated with CAR-T therapy | 期刊论文 | Xue Wang;Yuekun Qi;Hujun Li;Fengan Liu;Jiang Cao;Wei Chen;Ying Wang;Kunming Qi;Zhiling Yan;Feng Zhu;Zhenyu Li;Hai Cheng;Kailin Xu |
| 2 | Donor T-cell-derived interleukin-22 promotes thymus regeneration and alleviates chronic graft-versus-host disease in murine allogeneic hematopoietic cell transplant | 期刊论文 | Pan Bin;Zhang Fan;Lu Zhenzhen;Li Lingling;Shang Longmei;Xia Fan;Fu Ruixue;Xu Mengdi;Zeng Lingyu;Xu Kailin |
| 3 | Downregulation of long non-coding RNA TUG1 suppresses tumor growth by promoting ubiquitination of MET in diffuse large B-cell lymphoma | 期刊论文 | Cheng Hai;Yan Zhiling;Wang Xue;Cao Jiang;Chen Wei;Qi Kunming;Zhou Dian;Xia Jieyun;Qi Na;Li Zhenyu;Xu Kailin |
| 4 | Thymus Degeneration and Regeneration | 期刊论文 | Duah M;Li L;Shen J;Lan Q;Pan B;Xu K |
| 5 | IL-22 Accelerates Thymus Regeneration via Stat3/Mcl-1 and Decreases Chronic Graft-versus-Host Disease in Mice after Allotransplants | 期刊论文 | Pan Bin;Wang Dong;Li Lingling;Shang Longmei;Xia Fan;Zhang Fan;Zhang Ying;Gale Robert Peter;Xu Mengdi;Li Zhenyu;Xu Kailin |
| 6 | Kinetics of immune reconstitution after anti-CD19 chimeric antigen receptor T cell therapy in relapsed or refractory acute lymphoblastic leukemia patients | 期刊论文 | Wang Ying;Li Hujun;Song Xuguang;Qi Kunming;Cheng Hai;Cao Jiang;Shi Ming;Yan Zhiling;Jing Guangjun;Pan Bin;Sang Wei;Wang Xiangmin;Zhao Kai;Chen Chong;Chen Wei;Zheng Junnian;Li Zhenyu;Xu Kailin |
| 7 | Dynamic of plasma IL-22 level is an indicator of thymic output after allogeneic hematopoietic cell transplantation | 期刊论文 | Longmei Shang;Maxwell Duah;Yan Xu;Yiwen Liang;Dong Wang;Fan Xia;Lingling Li;Zengtian Sun;Zhiling Yan;Kailin Xu（徐开林）;Bin Pan |
| 8 | Janus kinase inhibitor ruxolitinib blocks thymic regeneration after acute thymus injury | 期刊论文 | Li Lingling;Shang Longmei;Gao Jun;Liu Cong;Xia Fan;Xu Mengdi;Qi Kunming;Zeng Lingyu;Pan Bin;Xu Kailin |
| 9 | Blockade of PD-1/PD-L1 increases effector T cells and aggravates murine chronic graft-versus-host disease | 期刊论文 | Yiwen Liang;Jingyi Shen;Qiu Lan;Kexin Zhang;Yan Xu;Maxwell Duah;Kailin Xu;Bin Pan |
| 10 | 联合应用药物克服嵌合抗原受体T细胞疗法耐药的研究进展 | 期刊论文 | 扈臣媛;徐开林;潘彬 |
| 11 | A combination of humanised anti-CD19 and anti-BCMA CAR T cells in patients with relapsed or refractory multiple myeloma: a single-arm, phase 2 trial | 期刊论文 | Yan Zhiling;Cao Jiang;Cheng Hai;Qiao Jianlin;Zhang Huanxin;Wang Ying;Shi Ming;Lan Jianping;Fei Xiaoming;Jin Lai;Jing Guangjun;Sang Wei;Zhu Feng;Chen Wei;Wu Qingyun;Yao Yao;Wang Gang;Zhao Jing;Zheng Junnian;Li Zhenyu;Xu Kailin |
| 12 | Efficacy and safety of CD19-specific CAR-T cell-based therapy in secondary central nervous system lymphoma | 期刊论文 | Huanxin Zhang;Zhiling Yan;Yucai Wang;Yuekun Qi;Yongxian Hu;Ping Li;Jiang Cao;Meng Zhang;Xia Xiao;Ming Shi;Jieyun Xia;Sha Ma;Jianlin Qiao;Hujun Li;Bin Pan;Kunming Qi;Hai Cheng;Haiying Sun;Feng Zhu;Wei Sang;Depeng Li;Zhenyu Li;Junnian Zheng;Mingfeng Zhao;Aibin Liang;He Huang;Kailin Xu |
| 13 | Assessment of oral ciprofloxacin impaired gut barrier integrity on gut bacteria in mice | 期刊论文 | Zhu Shengyun;Li Huiqi;Liang Jing;Lv Chaoran;Zhao Kai;Niu Mingshan;Li Zhenyu;Zeng Lingyu;Xu Kailin |
| 14 | Immune regulation of poly unsaturated fatty acids and free fatty acid receptor 4 | 期刊论文 | Duah M;Zhang K;Liang Y;Ayarick VA;Xu K;Pan B |
| 15 | PD‐1 antibody and ruxolitinib enhances graft‐versus‐lymphoma effect without increasing acute graft‐versus‐host disease in mice | 期刊论文 | Bin Pan;Longmei Shang;Cong Liu;Jun Gao;Fan Zhang;Mengdi Xu;Lingling Li;Zengtian Sun;Zhenyu Li;Kailin Xu |
| 16 | Inhibition of interleukin-1 receptor-associated kinase 1 decreases murine acute GVHD while preserving graft-versus-lymphoma effect | 期刊论文 | Gao J;Xu Y;Ma S;Liang Y;Liu C;Shen J;Sun Z;Niu M;Xu K;Pan B |
| 17 | Safety and efficacy of chimeric antigen receptor (CAR)-T-cell therapy in persons with advanced B-cell cancers and hepatitis B virus-infection | 期刊论文 | Wang Ying;Liu Yang;Tan Xu;Pan Bin;Ge Jian;Qi Kunming;Cheng Hai;Cao Jiang;Shi Ming;Yan Zhiling;Qiao Jianlin;Jing Guangjun;Wang Xue;Sang Wei;Xia Ruixiang;Zhang Xi;Li Zhenyu;Gale Robert Peter;Zheng Junnian;Zhu Feng;Xu Kailin |
| 18 | Selective inhibition of interleukin-1 receptor-associated kinase 1 ameliorates lipopolysaccharide-induced sepsis in mice | 期刊论文 | Pan Bin;Gao Jun;Chen Wei;Liu Cong;Shang Longmei;Xu Mengdi;Fu Chunling;Zhu Shengyun;Niu Mingshan;Xu Kailin |
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