表观遗传调控IL-1β及EphB2基因表达干扰NMDA受体跨膜转运影响突触可塑性参与术后认知障碍
81870852
2018
H0902.意识障碍与认知功能障碍
高灿
面上项目
教授
徐州医科大学
56万元
学习记忆;术后认知功能障碍;突触可塑性;NMDA受体跨膜转运;表观遗传学
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | HDAC3 of dorsal hippocampus induces postoperative cognitive dysfunction in aged mice | 期刊论文 | Li Yang;Jing-Ru Hao;Yin Gao;Xiu Yang;Xiao-Ran Shen;Hu-Yi Wang;Nan Sun;Can Gao |
| 2 | 一种手套嵌入式三腔多功能密封袋 | 专利 | 高灿;杨秀;刘乐;李旭;郝景茹 |
| 3 | DNA甲基化调控长期记忆形成的研究进展 | 期刊论文 | 高银;高灿 |
| 4 | β-Amyloid activates reactive astrocytes by enhancing glycolysis of astrocytes | 期刊论文 | Yuhan Zhang;Xiu Yang;Jingchao Zhuang;Hongquan Zhang;Can Gao |
| 5 | 组蛋白去乙酰化酶抑制剂对慢性社交挫败应激小鼠恐惧记忆消退的影响及作用机制 | 期刊论文 | 高寒;殷罗悦;汤淇凯;徐寒冰;高棽棽;郝景茹;高灿 |
| 6 | N-Methyl D-aspartate receptor subunit signaling in fear extinction. | 期刊论文 | Jelena Radulovic;LY Ren;Can Gao |
| 7 | dCA1-NAc shell glutamatergic projection mediates context-induced memory recall of morphine | 期刊论文 | Yue-Ying Liu;Le Liu;Lei Zhu;Xiu Yang;Kun Tong;Yue You;Li Yang;Yin Gao;Xu Li;Di-Shi Chen;Jing-Ru Hao;Nan Sun;Can Gao |
| 8 | 神经精神疾病突触可塑性机制及干预研究 | 奖励 | 高灿;颜景芝;韩园;孙楠;郝景茹;孙凯;胡蕊 |
| 9 | Ketamine improved depressive-like behaviors via hippocampal glucocorticoid receptor in chronic stress induced- susceptible mice | 期刊论文 | Wei Wang;Le Liu;Xiu Yang;Han Gao;Qi-Kai Tang;Luo-Yue Yin;Xiao-Yu Yin;Jing-Ru Hao;De-Qin Geng;Can Gao |
| 10 | Transferrin-Pep63-liposomes accelerate the clearance of Aβ and rescue impaired synaptic plasticity in early Alzheimer’s disease models | 期刊论文 | Xiu Yang;Xu Li;Le Liu;Yuan-Hao Chen;Yue You;Yin Gao;Yue-Ying Liu;Li Yang;Kun Tong;Di-Shi Chen;Jing-Ru Hao;Nan Sun;Zi-Ming Zhao;Can Gao |
| 11 | Excitatory VTA to DH projections provide a valence signal to memory circuits | 期刊论文 | Yuan Han;Yi Zhang;Haram Kim;Viktoriya S. Grayson;Vladimir Jovasevic;Wenjie Ren;Maria Virginia Centeno;Anita L. Guedea;Mariah A.A. Meyer;Yixin Wu;Philipp Gutruf;D. James Surmeier;Can Gao;Marco Martina;A. Vania Apkarian;John A. Rogers;Jelena Radulovic |
| 12 | 基底外侧杏仁核-上边缘皮质BDNF在小鼠围术期神经认知紊乱中的作用:与TrkB受体的关系 | 期刊论文 | 宋雨桐;仲达;高银;孙晓玉;高灿 |
| 13 | IQGAP1/ERK Regulates Fear Memory Formation via Histone Posttranslational Modifications Induced by HDAC2 | 期刊论文 | Xiao-Ya Liu;Bin Yao;Jing-Ru Hao;Lu Jin;Ya Gao;Xiu Yang;Le Liu;Xiao-Yu Sun;Nan Sun;Can Gao |
| 14 | Histone H3K9 Trimethylation Downregulates the Expression of Brain-Derived Neurotrophic Factor in the Dorsal Hippocampus and Impairs Memory Formation During Anaesthesia and Surgery | 期刊论文 | Tong Wu;Xiao-Yu Sun;Xiu Yang;Le Liu;Kun Tong;Ya Gao;Jing-Ru Hao;Jing Cao;Can Gao |
| 15 | Isoflurane impairs GluN2B-containing NMDA receptors trafficking and cognition via decreasing histone acetylation and EphB2 expression in aged hippocampal neurons. | 期刊论文 | Jing-Ru Hao;Xiao-Ya Liu;Xiu Yang;Pan Wei;Hu-Yi Wang;Nan Sun;Can Gao |
| 16 | 具有治疗阿尔茨海默病功效的纳米复合体及其制备方法与应用 | 专利 | 高灿;杨秀;赵子明;李旭;郝景茹 |
| 17 | HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction | 期刊论文 | Xiao-Yu Sun;Teng Zheng;Xiu Yang;Le Liu;Shen-Shen Gao;Han-Bin Xu;Yu-Tong Song;Kun Tong;Li Yang;Ya Gao;Tong Wu;Jing Ru;Chen Lu;Tao Ma;Can Gao |
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