精氨酸甲基转移酶PRMT7在多发性骨髓瘤浸润和转移过程中的作用机制研究

81600173
2016
H0811.骨髓瘤与浆细胞疾病
姚若斯
青年科学基金项目
副教授
徐州医科大学
18万元
转移;浸润;表观遗传调控;多发性骨髓瘤;精氨酸甲基转移酶7
2017-01-01到2019-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma 期刊论文 Xiaoyang Sun;Yu Xie;Xiaoshen Sun;Yao Yao;Hujun Li;Zhenyu Li;Ruosi Yao;Kailin Xu
2 Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration. 期刊论文 Yao Ruosi;Wang Yingli;Han Danyang;Ma Yuhui;Ma Musong;Zhao Yaping;Tan Jiang;Lu Jun;Xu Guiying;Li Xiaoxue
3 Anticancer effect of histone deacetylase inhibitor scriptaid as a single agent for hepatocellular carcinoma. 期刊论文 Liu Linlin;Sun Xiaoyang;Xie Yu;Zhuang Yinping;Yao Ruosi;Xu Kai
4 Identification of protein arginine methyltransferase 7 (PRMT7) inhibitor by virtual screening and biological evaluation in vitro 期刊论文 Linlin Liu;Xiaoning Kai;Qingqing Chen;Ling Zhang;Ruosi Yao;Jian Gao
5 Histone deacetylase inhibitor NaBut suppresses cell proliferation and induces apoptosis by targeting p21 in multiple myeloma. 期刊论文 Yao Ruosi;Han Danyang;Sun Xiaoyang;Fu Chunling;Wu Qingyun;Yao Yao;Li Hujun;Li Zhenyu;Xu Kailin
6 Scriptaid inhibits cell survival, cell cycle, and promotes apoptosis in multiple myeloma via epigenetic regulation of p21. 期刊论文 Yao Ruosi;Han Danyang;Sun Xiaoyang;Xie Yu;Wu Qingyun;Fu Chunling;Yao Yao;Li Hujun;Li Zhenyu;Xu Kailin
7 Identification of a novel c-Myc inhibitor with antitumor effects on multiple myeloma cells. 期刊论文 Yao Ruosi;Sun Xiaoyang;Xie Yu;Sun Xiaoshen;Yao Yao;Li Hujun;Li Zhenyu;Gao Jian;Xu Kailin
8 Anti-Proliferative Activity of HPOB against Multiple Myeloma Cells via p21 Transcriptional Activation. 期刊论文 Liu Linlin;Sun Xiaoyang;Xie Yu;Zhuang Yinping;Yao Ruosi;Xu Kai
9 Lithium chloride inhibits cell survival, overcomes drug resistance, and triggers apoptosis in multiple myeloma via activation of the Wnt/beta-catenin pathway. 期刊论文 Yao Ruosi;Sun Xiaoyang;Xie Yu;Liu Linlin;Han Danyang;Yao Yao;Li Hujun;Li Zhenyu;Xu Kailin
10 Integrating molecular dynamics simulation and molecular mechanics/ generalized Born surface area calculation into pharmacophore modeling: a case study on the proviral integration site for Moloney murine leukemia virus (Pim)-1 kinase inhibitors 期刊论文 Jian Gao;Yan Wang;Qingqing Chen;Ruosi Yao
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