甘草中刺甘草查尔酮靶向NLRP3炎症小体的作用及其机制研究
81903891
2019
H3212.中药抗炎与免疫药理
徐广
青年科学基金项目
副教授
中国人民解放军总医院
21万元
炎症疾病;甘草;NLRP3炎症小体;抗炎;刺甘草查尔酮
2020-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Icariside II, a main compound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancing NLRP3 inflammasome activation | 期刊论文 | Wang Zhilei;Xu Guang;Wang Hongbo;Zhan Xiaoyan;Gao Yuan;Chen Nian;Li Ruisheng;Song Xueai;Guo Yuming;Yang Ruichuang;Niu Ming;Wang Jiabo;Liu Youping;Xiao Xiaohe;Bai Zhaofang |
| 2 | Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases | 期刊论文 | Shi Wei;Xu Guang;Zhan Xiaoyan;Gao Yuan;Wang Zhilei;Fu Shubin;Qin Nan;Hou Xiaorong;Ai Yongqiang;Wang Chunyu;He Tingting;Liu Hongbin;Chen Yuanyuan;Liu Yan;Wang Jiabo;Niu Ming;Guo Yuming;Xiao Xiaohe;Bai Zhaofang |
| 3 | 刺甘草查尔酮作为抑制剂的用途 | 专利 | 柏兆方;肖小河;徐广;付书彬 |
| 4 | Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity | 期刊论文 | Qin Nan;Xu Guang;Wang Yan;Zhan Xiaoyan;Gao Yuan;Wang Zhilei;Fu Shubin;Shi Wei;Hou Xiaorong;Wang Chunyu;Li Ruisheng;Liu Yan;Wang Jiabo;Zhao Haiping;Xiao Xiaohe;Bai Zhaofang |
| 5 | Echinatin effectively protects against NLRP3 inflammasome driven diseases by targeting HSP90 | 期刊论文 | Xu Guang;Fu Shubin;Zhan Xiaoyan;Wang Zhilei;Zhang Ping;Shi Wei;Qin Nan;Chen Yuanyuan;Wang Chunyu;Niu Ming;Guo Yuming;Wang Jiabo;Bai Zhaofang;Xiao Xiaohe |
| 6 | Discovery of bakuchiol as an AIM2 inflammasome activator and cause of hepatotoxicity. | 期刊论文 | Tingting Liu;Guang Xu;Li Yurong;Shi wei;Lutong Ren;Zhie Fang;Liang longxin;Wang yan;Gao Yuan;Xiaoyan Zhan;Qiang Li;Wenqing Mou;Li Lin;Ziying Wei;Zhiyong Li;Wenzhang Dai;Jia Zhao;Hui Li;Wang Jiabo;Zhao Yanling;Xiao Xiaohe;Xiaohe Xiao |
| 7 | Dehydrocostus lactone inhibits NLRP3 inflammasome activation by blocking ASC oligomerization and prevents LPS-mediated inflammation in vivo | 期刊论文 | Chen Yuanyuan;Li Ruisheng;Wang Zhilei;Hou Xiaorong;Wang Chunyu;Ai Yongqiang;Shi Wei;Zhan Xiaoyan;Wang Jia-bo;Xiao Xiaohe;Bai Zhaofang;Sun Hongsheng;Xu Guang |
| 8 | Cryptotanshinone specifically suppresses NLRP3 inflammasome activation and protects against inflammasome-mediated diseases | 期刊论文 | Liu Hongbin;Zhan Xiaoyan;Xu Guang;Wang Zhilei;Li Ruisheng;Wang Yan;Qin Qin;Shi Wei;Hou Xiaorong;Yang Ruichuang;Wang Jian;Xiao Xiaohe;Bai Zhaofang |
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