基于核受体FXR研究芍药苷治疗淤胆型肝炎的生物学机制
81874365
2018
H3214.中药消化与呼吸药理
赵艳玲
面上项目
研究员
中国人民解放军总医院
57万元
淤胆型肝炎;法尼酯X受体;芍药苷;肝胆胰相关疾病;生物学机制
2019-01-01到2022-12-31
- 中英文摘要
- 结题摘要
- 结题报告
- 项目成果
- 项目参与人
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| 序号 | 标题 | 类型 | 作者 |
|---|---|---|---|
| 1 | Mechanism of Hydrophobic Bile Acid-Induced Hepatocyte Injury and Drug Discovery | 期刊论文 | Shizhang Wei;Xiao Ma;Yanling Zhao |
| 2 | Paeoniflorin Protects against ANIT-Induced Cholestatic Liver Injury in Rats via the Activation of SIRT1-FXR Signaling Pathway | 期刊论文 | Chen Lisheng;Wei Shizhang;Liu Honghong;Li Jianyu;Jing Manyi;Tong Yuling;Li Ruisheng;Wen Jianxia;Zhan Hanqiu;Zhao Yanling |
| 3 | Therapeutic Opportunities of GPBAR1 in Cholestatic Diseases | 期刊论文 | Fangling Zhang;Xiaolin Xiao;Yong Li;Hefei Wu;Xinyu Deng;Yinxiao Jiang;Wenwen Zhang;Jian Wang;Xiao Ma;Yanling Zhao |
| 4 | Baicalin and the liver-gut system: Pharmacological bases explaining its therapeutic effects | 期刊论文 | Qichao Hu;Wenwen Zhang;Zhao Wu;Xin Tian;Junbao Xiang;Longxuan Li;Zhihao Li;Xi Peng;Shizhang Wei;Xiao Ma;Yanling Zhao |
| 5 | Validation of MAPK signalling pathway as a key role of paeoniflorin in the treatment of intrahepatic cholestasis of pregnancy based on network pharmacology and metabolomics | 期刊论文 | Jiawei Wang;Jianxia Wen;Xiao Ma;Ju Yang;Zhao Zhang;Shuying Xie;Shizhang Wei;Manyi Jing;Haotian Li;Liwei Lang;Xuelin Zhou;Yanling Zhao |
| 6 | Natural products for the prevention and treatment of cholestasis: A review | 期刊论文 | Xiao Ma;Yinxiao Jiang;Wenwen Zhang;Jiabo Wang;Ruilin Wang;Lifu Wang;Shizhang Wei;Jianxia Wen;Haotian Li;Yanling Zhao |
| 7 | Mechanism of Paeoniflorin in the Treatment of Bile Duct Ligation-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology | 期刊论文 | Shizhang Wei;Xiao Ma;Ming Niu;Ruilin Wang;Tao Yang;Dan Wang;Jianxia Wen;Haotian Li;Yanling Zhao |
| 8 | Paeoniflorin, a Natural Product With Multiple Targets in Liver Diseases—A Mini Review | 期刊论文 | Xiao Ma;Wenwen Zhang;Yinxiao Jiang;Jianxia Wen;Shizhang Wei;Yanling Zhao |
| 9 | Comparative Evidence for Intrahepatic Cholestasis of Pregnancy Treatment With Traditional Chinese Medicine Therapy: A Network Meta-Analysis | 期刊论文 | Yinxiao Jiang;Haotian Li;Dan Song;Penghui Ye;Nuo Xu;Yuan Chen;Wenwen Zhang;Qichao Hu;Xiao Ma;Jianxia Wen;Yeyu Li;Yanling Zhao |
| 10 | Mechanism of Paeoniflorin on ANIT-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology | 期刊论文 | Lisheng Chen;Xu Zhao;Shizhang Wei;Xiao Ma;Honghong Liu;Jianyu Li;Manyi Jing;Min Wang;Yanling Zhao |
| 11 | Old wine in new bottles: Kaempferol is a promising agent for treating the trilogy of liver diseases | 期刊论文 | Xiaolin Xiao;Qichao Hu;Xinyu Deng;Kaiyun Shi;Wenwen Zhang;Yinxiao Jiang;Xiao Ma;Jinhao Zeng;Xiaoyin Wang |
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