乙型肝炎病毒多重耐药的发生演变机制与优化治疗方法研究

81371852
2013
H2103.肝炎病毒与感染
刘妍
面上项目
副研究员
中国人民解放军总医院
70万元
演变机制;乙型肝炎病毒;基因型和表型分析;多重耐药;优化治疗
2014-01-01到2017-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China 期刊论文 Xiaodong Li;Yan Liu;Shaojie Xin;Dong Ji;Shaoli You;Jinhua Hu;Jun Zhao;Jingjing Wu;Hao Liao;Xinxin Zhang;Dongping Xu
2 乙型肝炎病毒阿德福韦酯耐药相关变异的研究进展 期刊论文 叶晓玲;刘妍;徐东平
3 Extending duration is essential for tenofovir-based antiviral for the patients with history of multidrug resistant HBV infection 会议论文 Yi Zhou;Yan Liu;Rongjuan Chen;Zhihui Xu;Le Li;Peng Rui;Min Liu;Dongping Xu
4 针对不同靶点的抗HBV 新药研究进展 期刊论文 许智慧;刘妍;徐东平
5 105例多重耐药乙型肝炎病毒感染的临床病毒学特点分析 会议论文 刘妍;许智慧;李晓东;李乐;陈容娟;陈丽;杨媛;辛绍杰;徐东平
6 阿德福韦酯持续培养HepG2.2.15细胞诱导其发生经典耐药突变 期刊论文 李奇;杨媛;李乐;刘妍;苗福珍;李韦杰;蔡少平;徐东平
7 An eight-year summary of hepatitis B virus entecavir-resistant mutation profile in the clinical practice of Beijing 302 Hospital of China 会议论文 Yan Liu;Zhihui Xu;Xiaodong Li;Rongjuan Chen;Lanlan Si;Dong Ji;Le Li;Dongping Xu
8 乙型肝炎病毒多聚酶/反转录酶区耐药变异的研究进展 期刊论文 赵丽;苏何玲;刘妍;徐东平
9 乙型肝炎病毒反转录酶区rtI233V变异的演变及病毒学特点分析 期刊论文 叶晓玲;刘妍;陈容娟;许智慧;李晓东;叶海燕;唐振祥;程书权;徐东平
10 Fourteen-year follow-up of a chronic hepatitis B patient who successively developed lamivudine-, adefovir-, entecavir-, and multidrug-resistance 会议论文 Yan Liu;Zhihui Xu;Xiaodong Li;Rongjuan Chen;Lanlan Si;Dong Ji;Le Li;Dongping Xu
11 替诺福韦酯对阿德福韦酯治疗耐药患者的挽救治疗研究进展 期刊论文 邵金曼;刘妍;徐东平
12 An eight-year summary of hepatitis B virus entecavir-resistant mutation profile in the clinical practice of Beijing 302 Hospital of China 会议论文 Yan Liu;Zhihui Xu;Xiaodong Li;Rongjuan Chen;Lanlan Si;Dong Ji;Le Li;Dongping Xu
13 An eight-year summary of hepatitis B virus entecavir-resistant mutation profile in the clinical practice of Beijing 302 Hospital of China 会议论文 Yan Liu;Jinman Shao;Zhihui Xu;Xiaodong Li;Rongjuan Chen;Lanlan Si;Dong Ji;Le Li;Dongping Xu
14 The establishment of a stable replication and expression mouse model of multidrug-resistant genotype C HBV 会议论文 Yue Yang;Yan Liu;Xiaoyan Dong;Zhihui Xu;Shuangqing Yu;Lanlan Si;Ruisheng Li;Xiaobing Wu;Dongping Xu
15 C基因型多重耐药HBV稳定复制表达小鼠模型的建立 会议论文 杨悦;高俪;许智慧;余双庆;乔艳;李进;董小岩;吴小兵;刘妍;徐东平
16 中国流行株C基因型HBV稳定复制表达小鼠模型的建立 期刊论文 杨悦;高俪;许智慧;余双庆;乔艳;李进;董小岩;吴小兵;刘妍;徐东平
17 The rtA181S mutation of hepatitis B virus primarily confers resistance to adefovir dipivoxil 期刊论文 Yan Liu;Xiaodong Li;Shaojie Xin;Zhihui Xu;Rongjuan Chen;Jing Yang;Liming Liu;Wong Vincent Wai-Sun;Dongliang Yang;Chan Henry Lik-Yuen;Dongping Xu
18 The establishment of a stable replication and expression mouse model of multidrug-resistant genotype C HBV 会议论文 Yue Yang;Yan Liu;Xiaoyan Dong;Zhihui Xu;Shuangqing Yu;Lanlan Si;Ruisheng Li;Dongping Xu;Xiaobing Wu
19 一种乙型肝炎病毒复制中间体核心颗粒DNA的提取方法 专利 徐东平;刘妍;姚伟明;许智慧;李晓东
20 rtM204Q may serve as a novel lamivudine-resistance-associated mutation of hepatitis B virus 期刊论文 Yan Liu;Zhihui Xu;Yan Wang;Xiaodong Li;Liming Liu;Li Chen;Shaojie Xin;Dongping Xu
21 Fourteen-year follow-up of a chronic hepatitis B patient who successively developed lamivudine-, adefovir-, entecavir-, and multidrug-resistance 会议论文 Li Zhao;Yan Liu;Zhihui Xu;Xiaodong Li;Rongjuan Chen;Dong Ji;Le Li;Lanlan Si;Dongping Xu
22 Increased occurrence of mutant rtI233V of HBV in patients receiving adefovir therapy 期刊论文 Yan Liu;Shaojie Xin;Xiaoling Ye;Rongjuan Chen;Zhihui Xu;Xiaodong Li;Haiyan Ye;Shuquan Cheng;Dongping Xu
23 HBV rtL180M+A181C+M204V mutations may lead to entecavir resistance in real-life clinical practice 会议论文 Yi Zhou;Yan Liu;Rongjuan Chen;Zhihui Xu;Jinman Shao;Min Liu;Dongping Xu
24 多重耐药乙型肝炎病毒感染特点及挽救治疗策略 期刊论文 周怡;刘妍;徐东平;刘敏
25 HBV动物模型研究进展 期刊论文 杨悦;许智慧;刘妍;徐东平
26 多重耐药HBV感染患者在恩替卡韦和阿德福韦酯联合治疗应答不佳后替诺福韦酯挽救治疗期间病毒变异演变分析 会议论文 周怡;陈容娟;许智慧;李乐;芮鹏;刘敏;刘妍;徐东平
27 The rtA181S mutation of hepatitis B virus primarily confers resistance to adefovir dipivoxil 会议论文 Yan Liu;Xiaodong Li;Shaojie Xin;Zhihui Xu;Rongjuan Chen;Jing Yang;Li Chen;Vincent Wai-Sun Wong;Dongliang Yang;Henry Lik-Yuen Chan;Dongping Xu
28 肝衰竭诊疗临床教程(第6章 肝衰竭研究进展,第二节 乙型肝炎病毒基因变异与乙型肝炎重症化) 专著 刘妍;徐东平
29 慢性HBV感染的抗病毒治疗方法优化现状及展望 期刊论文 张凯;刘妍;徐东平;蔺淑梅
30 Fourteen-year follow-up of a chronic hepatitis B patient who successively developed lamivudine-, adefovir-, entecavir-, and multidrug-resistance 会议论文 Yan Liu;Zhihui Xu;Xiaodong Li;Rongjuan Chen;Lanlan Si;Dong Ji;Le Li;Dongping Xu
31 The rtA181S mutation in the reverse-transcriptase domain of hepatitis B virus is associated with adefovir dipivoxil resistance 会议论文 Yan Liu;Xiaodong Li;Zhihui Xu;Rongjuan Chen;Jing Yang;Liming Liu;Shaojie Xin;Dongping Xu
32 Screening and identification of a novel adefovir dipivoxil -resistance-associated mutation rtN236V of hepatitis B virus (HBV) from a large cohort of HBV-infected patients 期刊论文 Yan Liu;Wenhui Liu;Xiaodong Li;Zhihui Xu;Xiao Wang;Changxing Li;Li Chen;Shaojie Xin;Dongping Xu
33 Extending duration is essential for tenofovir-based antiviral for the patients with history of multidrug resistant HBV infection 会议论文 Yi Zhou;Yan Liu;Rongjuan Chen;Zhihui Xu;Le Li;Peng Rui;Min Liu;Dongping Xu
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