GSDMD介导细胞焦亡在阿霉素诱导心脏毒性发病机制中的研究

81903727
2019
H3512.药物毒理
韩集波
青年科学基金项目
医师
嘉兴学院
21万元
细胞焦亡;新靶点;阿霉素;GSDMD;心脏毒性
2020-01-01到2022-12-31
  • 中英文摘要
  • 结题摘要
  • 结题报告
  • 项目成果
  • 项目参与人
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序号 标题 类型 作者
1 DL-3-n-butylphthalide prevents oxidative stress and atherosclerosis by targeting Keap-1 and inhibiting Keap-1/Nrf-2 interaction 期刊论文 Jibo Han;Xiaowen Shi;Jiajun Xu;Wante Lin;Yanghao Chen;Bingjiang Han;Yi Wang;Jianjiang Xu
2 Wogonin alleviates cisplatin-induced cardiotoxicity in mice via inhibiting GSDMD-mediated pyroptosis 期刊论文 Jiajun Xu;Bin Zhang;Zhenliang Chu;Fenfen Jiang;Jibo Han
3 DL-3-n-Butylphthalide Attenuates Myocardial Hypertrophy by Targeting Gasdermin D and Inhibiting Gasdermin D Mediated Inflammation 期刊论文 Bingjiang Han;Jiajun Xu;Xiaowen Shi;Zhanxiong Zheng;Fengjie Shi;Fenfen Jiang;Jibo Han
4 Gasdermin D mediates doxorubicin-induced cardiomyocyte pyroptosis and cardiotoxicity via directly binding to doxorubicin and changes in mitochondrial damage 期刊论文 Bozhi Ye;Xiaowen Shi;Jianjiang Xu;Shanshan Dai;Jiajun Xu;Xiaoxi Fan;Bingjiang Han;Jibo Han
5 GSDMD (Gasdermin D) Mediates Pathological Cardiac Hypertrophy and Generates a Feed-Forward Amplification Cascade via Mitochondria-STING (Stimulator of Interferon Genes) Axis 期刊论文 Jibo Han;Shanshan Dai;Lingfeng Zhong;Xiaowen Shi;Xiaoxi Fan;Xin Zhong;Wante Lin;Lan Su;Shuang Lin;Bingjiang Han;Jianjiang Xu;Xia Hong;Weijian Huang;Bozhi Ye
6 Activation of STING Pathway Contributed to Cisplatin-Induced Cardiac Dysfunction via Promoting the Activation of TNF-α-AP-1 Signal Pathway 期刊论文 Lintao Wang;Suya Zhang;Jibo Han;Xiaoyan Nie;Yajun Qi;Yingying Han;Xiong Chen;Chaoyong He
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